|
Papillary thyroid carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Q-MSP showed that methylation levels of the HOXD10 promoter were significantly higher in PTC tissues than levels in the adjacent normal thyroid tissues (P=0.02).
|
29115628 |
2018 |
|
Disseminated Malignant Neoplasm
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Data analysis together proved that D/PSP@CQ/CaP decreased the cancer metastatic extent by 7.5 folds (vs. Control) on mice model via inhibiting the autophagy-dependent disassembly of focal adhesion.
|
29574131 |
2018 |
|
Osteosarcoma of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
These observations indicate that low concentrations of MSP-4 can help induce the apoptosis of MG63 through a Fas/FasL- and mitochondria-mediated pathway and suggest a potentially innovative alternative to the treatment of human osteosarcoma.
|
29301308 |
2018 |
|
Childhood Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These observations indicate that low concentrations of MSP-4 can help induce the apoptosis of MG63 through a Fas/FasL- and mitochondria-mediated pathway and suggest a potentially innovative alternative to the treatment of human osteosarcoma.
|
29301308 |
2018 |
|
Mammary Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
We evaluated <i>ESR1</i> methylation in CTCs and paired plasma ctDNA as a potential biomarker for response to everolimus/exemestane treatment.<b>Experimental Design:</b> A highly sensitive and specific real-time MSP assay for <i>ESR1</i> methylation was developed and validated in (i) 65 primary breast tumors formalin-fixed paraffin-embedded (FFPE), (ii) EpCAM<sup>+</sup> CTC fractions (122 patients and 30 healthy donors; HD), (iii) plasma ctDNA (108 patients and 30HD), and (iv) in CTCs (CellSearch) and in paired plasma ctDNA for 58 patients with breast cancer.
|
29284708 |
2018 |
|
Vertical supranuclear gaze palsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Differentiating clinically progressive supranuclear palsy-parkinsonism (PSP-P) from Parkinson's disease (PD) may be challenging, especially in the absence of vertical supranuclear gaze palsy (VSGP).
|
30068492 |
2018 |
|
Severe periodontitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Sixteen subjects with no or mild periodontitis (NMP group) and 15 subjects with moderate or severe periodontitis (MSP group) were enrolled.
|
29524787 |
2018 |
|
Atypical Parkinsonism
|
0.010 |
Biomarker
|
disease |
BEFREE |
We suggest possible aetiologies for this constellation of symptoms, discuss the possible origin of these signs and highlight this phenotype as it may mimic atypical parkinsonism and in particular PSP.
|
29801913 |
2018 |
|
Stage 0 Breast Cancer AJCC v6 and v7
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This retrospective series includes all of the 1531 cases of invasive and in situ breast cancer (DCIS, ductal carcinoma in situ) that were newly diagnosed in two certified breast care centers in Münster in the period 2006-2012 among women in the MSP target population.
|
30149831 |
2018 |
|
Rheumatoid Arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
BCL11B, CCDC88C, FCRLA and APOL6 were both up-regulated and hypomethylated in RA according to integrated analysis, RT-PCR and MSP verification.
|
28882568 |
2017 |
|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with BD were recruited from psychiatric outpatient clinics, and assessed with the Young Mania Rating Scale (YMRS), the Montgomery-Åsberg Depression Rating Scale (MADRS), the Clinical Global Impression Scale (CGI)-Bipolar and CGI-Depression, the Positive and Negative Symptom Scale (PANSS), the Global assessment of function (GAF), and the PSP.
|
28343053 |
2017 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with BD were recruited from psychiatric outpatient clinics, and assessed with the Young Mania Rating Scale (YMRS), the Montgomery-Åsberg Depression Rating Scale (MADRS), the Clinical Global Impression Scale (CGI)-Bipolar and CGI-Depression, the Positive and Negative Symptom Scale (PANSS), the Global assessment of function (GAF), and the PSP.
|
28343053 |
2017 |
|
Pneumothorax
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We retrospectively reviewed and stratified 938 instances of pneumothorax in 751 consecutive patients diagnosed with SP into the PSP and SSP groups.
|
28386166 |
2017 |
|
Rectal Prolapse
|
0.010 |
Biomarker
|
disease |
BEFREE |
The PSP-resection seems to be a safe and fast therapeutic option not only for older, frail patients with external rectal prolapse.
|
28374985 |
2017 |
|
Spontaneous pneumothorax
|
0.010 |
Biomarker
|
disease |
BEFREE |
We retrospectively reviewed and stratified 938 instances of pneumothorax in 751 consecutive patients diagnosed with SP into the PSP and SSP groups.
|
28386166 |
2017 |
|
Neoplasm, Residual
|
0.010 |
PosttranslationalModification
|
phenotype |
BEFREE |
DNA CY1 detected by Q-MSP for CDO1 gene promoter DNA methylation has a great potential to detect minimal residual disease of the peritoneum in GC clinics as a novel DNA marker.
|
28243814 |
2017 |
|
Adult Glioblastoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The RT-MSP assay that we developed in-house is a robust clinical detection method for the heterogeneous process of MGMT promoter methylation in glioblastoma.
|
28967952 |
2017 |
|
Childhood Glioblastoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The RT-MSP assay that we developed in-house is a robust clinical detection method for the heterogeneous process of MGMT promoter methylation in glioblastoma.
|
28967952 |
2017 |
|
Depressed mood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Patients with BD were recruited from psychiatric outpatient clinics, and assessed with the Young Mania Rating Scale (YMRS), the Montgomery-Åsberg Depression Rating Scale (MADRS), the Clinical Global Impression Scale (CGI)-Bipolar and CGI-Depression, the Positive and Negative Symptom Scale (PANSS), the Global assessment of function (GAF), and the PSP.
|
28343053 |
2017 |
|
Neurobehavioral Manifestations
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Atrophy colocated with cerebellar areas implicated for motor (PSP, MSA) or cognitive symptoms (FTD, ALS, PSP) in the diseases.
|
28501823 |
2017 |
|
Squamous cell carcinoma of skin
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The in vivo methylation levels of 5' G0S2 CGI as determined by RT-MSP varied widely (0.0% to 77.7%) in 17 cutaneous SCC samples and narrowly (0.1% to 7.3%) in 6 normal epidermis samples.
|
29073263 |
2017 |
|
Stuttering, Developmental
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Sex steroid hormones and sex hormone binding globulin levels, CYP17 MSP AI (-34T:C) and CYP19 codon 39 (Trp:Arg) variants in children with developmental stuttering.
|
28992603 |
2017 |
|
Glioblastoma Multiforme
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The RT-MSP assay that we developed in-house is a robust clinical detection method for the heterogeneous process of MGMT promoter methylation in glioblastoma.
|
28967952 |
2017 |
|
Hereditary Prostate Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In prostate adenocarcinoma, besides mutations in BRCA1 and BRCA2 genes that are known to increase the incidence of high-risk cancer in young patients, new studies have shown mutation in other gene such as HOXB13 and also polymorphisms in MYC, MSMB, KLK2 and KLK3 that can be related to hereditary prostate cancer.
|
27819754 |
2017 |
|
keratoacanthoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Among the common hypermethylated CGIs, RT-MSP and bisulfite sequencing targeting CGIs located on CCDC17, PVR, and MAP3K11 gene bodies also showed that methylation levels were significantly higher in KA than in normal epidermis.
|
27788211 |
2016 |