Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The MTHFR genotype and allele frequencies were not different between diabetic patients with and without nephropathy (chi2 = 3, 386, p > 0.005; chi2 = 2.320, p > 0.005, respectively).
|
17354258 |
2007 |
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The aim of this study was to investigate the relationship between methylation profile in the MTHFR gene promoter and biochemical, inflammatory and oxidative stress markers in individuals with type 2 diabetes (T2DM) who have been diagnosed for 5-10 years with or without diabetic retinopathy (DR) and nephropathy (DN).
|
29075332 |
2017 |
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
An MTHFR variant, homocysteine, and cardiovascular comorbidity in renal disease.
|
11532106 |
2001 |
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The prevalence of polymorphism in the methylene-tetrahydro-folate-reductase (MTHFR) gene (677C-->T) was evaluated in diabetic pregnancy complicated by preeclampsia, nephropathy, retinopathy, and preterm delivery.
|
11531629 |
2001 |
Kidney Diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice.
|
18551038 |
2008 |
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We analyzed 821 subjects with hypertensive nephrosclerosis from the longitudinal National Institute of Diabetes and Digestive and Kidney Diseases African-American Study of Kidney Disease and Hypertension (AASK) Trial to determine whether decline in glomerular filtration rate (GFR) over ∼4.2 years was predicted by common genetic variation within MTHFR at non-synonymous positions C677T (Ala222Val) and A1298C (Glu429Ala) or by MTHFR haplotypes.
|
21613384 |
2012 |
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
To support our suggestion, we examined in detail the association of MTHFR polymorphism with diabetic retinopathy and nephropathy in Japanese type 2 diabetic patients.
|
18280442 |
2008 |
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The MTHFR genotype and allele frequencies were not significantly different between patients with and without nephropathy.
|
10765003 |
2000 |
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A total of 40 male patients with CKD and stable renal function (Kidney Disease Outcomes Quality Initiative stages 2 and 3) were classified according to MTHFR polymorphism as carrier T(+) or non carrier T(-).
|
24711158 |
2014 |
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
MTHFR C677T and A1298C polymorphisms were not associated with the presence of renal disease.
|
19376104 |
2009 |
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The MTHFR genotype and allele frequencies were different between diabetic patients with and without nephropathy (chi2=12.27, P<0.005; chi2=8.77, P<0.005, respectively).
|
15126006 |
2004 |
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The allele frequency of the C677T polymorphism in the MTHFR gene was 0.313 in the whole study population [wild-type (CC), 301; heterozygous (CT), 272; and homozygous mutant (TT), 63 patients, respectively] and showed no difference in the patient subgroups with various renal diseases.
|
10027946 |
1999 |
Kidney Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The MTRR 66GG and MTHFR 1298 CC genotypes may confer protection against early nephropathy, possibly because they are associated with lower tHcy.
|
18774994 |
2008 |