Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) gene mutations were studied in consecutive Alzheimer's Disease & Memory Clinic patients up to December 2014.
|
26401555 |
2015 |
Alzheimer's Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our data suggest a critical role for IL-8/MTHFR interactions in the development of AD.
|
19246914 |
2009 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MTHFR TT genotype was more prevalent in AD patients with milder alcohol dependence (Babor type A) and with Lesch type 3, associated with depression.
|
19650814 |
2009 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this meta-analysis supports that MTHFR C677T polymorphism is capable of causing AD susceptibility in East Asians, not in Caucasians.
|
20600372 |
2010 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The MTHFR C677T polymorphism may be a risk factor for AD in Asians, APOE ϵ4 carriers, and late-onset AD.
|
25486592 |
2015 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest an association between the MTHFR A1298C mutation and AD; however, the MTHFR C677T mutation did not contribute to susceptibility for AD.
|
23659764 |
2013 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic effect of MTHFR C677T polymorphism on the structural covariance network and white-matter integrity in Alzheimer's disease.
|
28342207 |
2017 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found that plasma total homocysteine is increased in AD patients (p < 0.0001) and depended on the MTHFR T/T genotype in the presence of low folate levels (p < 0.05).
|
12784029 |
2003 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The MTHFR C677T polymorphism is associated with AD in Asian populations, but not in Caucasians.
|
21663380 |
2011 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In spite of the evidence that a C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene elevates plasma Hcy levels, the impact of the C677T polymorphism on the development of AD is controversial.
|
15123333 |
2004 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that the MTHFR polymorphism does not contribute to genetic susceptibility in Italian sporadic AD and does not mitigate the effect of ApoE epsilon4 allele on AD risk.
|
11711225 |
2001 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this case-control study, we examined C677T and A1298C (rs1801133 and rs1801131) polymorphism in the methylenetetrahydrofolate reductase (MTHFR) genes and their correlation with plasma levels of homocysteine (Hcy) in AD and VaD cases and evaluated the gene-gene interaction (epistasis) with IL-6-174 G/C (rs1800795).
|
22015309 |
2012 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although MTHFR and MS polymorphisms have been shown to be positively associated with AD in some populations, the relationship of the CBS gene with AD remains undefined.
|
15975077 |
2004 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We detected a significant association of the MTHFR rs1801133 and PICALM rs3851179 polymorphisms with AD.
|
25359311 |
2015 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although the MTHFR gene C677T polymorphism has a significant impact on reducing enzyme activity and increasing t-Hcy concentrations, the association between the C677T polymorphism and AD remains inconclusive.
|
16055944 |
2005 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These reports were combined with related observational studies, and used to evaluate the effect of MTHFR C677T (rs1801133) on the risk for AD.
|
27031476 |
2016 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, in our study, MTHFR C677-->T and ACE I/D polymorphisms do not appear to confer an added risk for AD.
|
12928053 |
2003 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In AD there were significant differences of the levels of only Cys (GG, MTHFR, G1793A) and Met/Hcy (AA, MTHFD1, G1958A) whereas in PD there were more significant differences of the levels of thiols: Hcy [MTHFR: CT (C677T) and GG (G1793A); MTR, AG (A2756G)], Met [MTR, AA (A2756G)], Cys [MTR, AG (A2756G)], and Met/Hcy [MTHFR: CC, CT (C677T) and AA (A1298C), and GG (G1793A); MTHFD1 AA(G1958A); MTR AA(A2756G)].
|
17691219 |
2007 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A trend of association between TT genotype of MTHFR c.677C>T and AD was found [adjusted OR (95% CI): 1.73 (0.80-3.74)].
|
17932993 |
2008 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, our study does not reinforce the hypothesis of an independent involvement of the MTHFR gene upstream region polymorphisms in AD risk.
|
14739536 |
2004 |
Alzheimer's Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genetic polymorphisms of brain-derived neurotrophic factor, apolipoprotein E, interleukin 1-beta, and methylenetetrahydrofolate reductase have been demonstrated to confer increased risk to both LLD and AD by studies examining either LLD or AD patients.
|
27060956 |
2016 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Significantly, common functional polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene are a risk factor for the development of late-onset AD.
|
29865064 |
2018 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The result of cumulative meta-analysis sorted by publication year was also detected a dynamic tendency of no correlation between MTHFR A1298C polymorphism and AD.
|
28281392 |
2017 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Results of present meta-analysis supported that the MTHFR C677T polymorphism was associated with an increased risk of AD.
|
26820674 |
2017 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that the ApoE epsilon 4 genotype and the MTHFR mutation are associated with the clinical phenotype and the clinical onset of senile dementia.
|
10860300 |
2000 |