|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
8, 10 %); (2) MutYH mutated polyposis (MAP), adenomas >50 % and biallelic MutYH mutations (no.
|
27783336 |
2017 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Adenomas and carcinomas from patients with MYH biallelic mutation showed a different pattern of expression: a strong granular cytoplasmic staining was observed without any nuclear expression.
|
16890597 |
2006 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
MYH biallelic mutation carriers were up to 60% (5 of 8) among patients showing at least 30 adenomas and a family history with no vertical transmission of polyposis.
|
15188161 |
2004 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
MYH, OGG1 and MTH1 are members of base excision repair (BER) families, and MYH germline mutations were recently identified in patients with multiple adenomas or familial adenomatous polyposis (FAP).
|
15449173 |
2004 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Absence of MutY homologue mutation in patients with multiple sporadic adenomatous polyps in Korea.
|
16521226 |
2006 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
After further requests, her family case history revealed that her brother had had between 10 and 15 adenomas and turned out to carry both MUTYH germ line mutations.
|
18172263 |
2008 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Although the number of adenomas appears to be dependent on the number of mutated MYH alleles present in a patient, little is known on the relation of this number with cancer risk.
|
17949294 |
2007 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Among patients with multiple adenomas, biallelic MYH mutations account for approximately 30% of APC mutation negative cases and two thirds of these carry mutations other than the "common" Y165C and G382D variants.
|
17219385 |
2007 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
APC or MUTYH mutations account for the majority of clinically well-characterized families with FAP and AFAP phenotype and patients with more than 30 adenomas.
|
19793053 |
2009 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
AXIN2 and MUTYH genes were screened for germline mutations by PCR and direct sequencing in 39 unrelated patients with multiple adenomas or colorectal cancer without evidence of APC mutation nor mismatch repair defect.
|
16941501 |
2006 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Because biallelic MYH mutations occur in patients with both high and low numbers of adenomas, we hypothesized that MYH is involved in the tumorigenesis of microsatellite stable colorectal cancers in patients without vertical transmission of disease and who fulfill the Bethesda guidelines.
|
16645203 |
2006 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Bi-allelic germline mutations in the MUTYH gene give rise to multiple adenomas and an increased incidence of colorectal cancer.
|
16943222 |
2006 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Biallelic germline MUTYH mutations have been proved to greatly predispose to non-familial adenomatous polyposis (FAP) and non-hereditary non-polyposis colorectal cancer (HNPCC) familial recessive forms of colorectal cancer with multiple adenomas.
|
17931073 |
2007 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C-->T:A mutations.
|
12393807 |
2002 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Germline mutations of the MYH gene in Japanese patients with multiple colorectal adenomas.
|
15890374 |
2005 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Mutations in MBD4 are unlikely to be implicated in HPS; MYH mutations should be studied, especially when adenomas occur in the same patient.
|
16831587 |
2006 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Mutations in the MYH gene should be considered in individuals with multiple adenomas whose family history does not reflect an autosomal dominant pattern of inheritance.
|
15947872 |
2005 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
LHGDN |
None of the 141 normal-population adenoma patients carried biallelic germline MYH variants (95% CI = 0.06-4.1%) and 3 were heterozygotes (2.1%).
|
14999774 |
2004 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
One of 75 cancers had bi-allelic germline mutations in MYH and on retrospective analysis of medical records this patient was found to have synchronous multiple small adenomas in addition to carcinoma.
|
12707038 |
2003 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our objective was to determine the significance of MYH mutations in a series of Canadian patients with multiple adenomas.
|
17219385 |
2007 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Recently, biallelic mutations in the base excision repair gene MYH have been shown to predispose to a multiple adenoma and carcinoma phenotype.
|
16287072 |
2006 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Recently, germline mutations in the base-excision repair gene MYH (1p33-34) have been described in patients with multiple adenomas, pointing to a possible role as disease modifier in FAP.
|
14735163 |
2004 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Recessively inherited mutations in the base excision repair gene MYH have recently been associated with predisposition to colorectal adenomas and cancer in materials selected for occurrence of multiple adenomas.
|
12937124 |
2003 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
LHGDN |
The heterozygous genotype of OGG1 c.1-18G>T was closely associated with multiple adenoma families (P < 0.001), while MYH A359V mutation exhibited a tendency (P = 0.053).
|
17252231 |
2007 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
LHGDN |
The multiple colorectal adenoma phenotype and MYH, a base excision repair gene.
|
15290654 |
2004 |