MYB, MYB proto-oncogene, transcription factor, 4602

N. diseases: 206; N. variants: 30
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.100 Biomarker disease BEFREE Amplification of MYB DNA has been reported in two cell lines, ML-1 and ML-3, derived from a patient with acute myelogenous leukemia. 3281804 1988
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.020 Biomarker phenotype BEFREE Until now, only a few reports have described elevated c-myb gene expression in epithelial tissue, suggesting that under certain circumstances, c-Myb protein might play a role during the process of malignant transformation of epithelial cells. 7671256 1995
CUI: C0023418
Disease: leukemia
leukemia 		0.100 GeneticVariation disease BEFREE Thus the characterization of this rearrangement has yielded a new set of probes for the study of chromosome 6q abnormalities in human leukemias and lymphomas and provides the first evidence for potential involvement of the c-MYB locus itself in submicroscopic deletions within chromosome 6. 8039161 1994
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.030 GeneticVariation group BEFREE Thus the characterization of this rearrangement has yielded a new set of probes for the study of chromosome 6q abnormalities in human leukemias and lymphomas and provides the first evidence for potential involvement of the c-MYB locus itself in submicroscopic deletions within chromosome 6. 8039161 1994
CUI: C0742597
Disease: colon (non-specific) lesion
colon (non-specific) lesion 		0.010 GeneticVariation disease BEFREE Detection of C-myb genetic alterations and mutant p53 serum protein in patients with benign and malignant colon lesions. 8067719 1994
CUI: C0025202
Disease: melanoma
melanoma 		0.060 Biomarker disease BEFREE These results suggest that the MYB gene may play an important, though undefined, role in the growth of at least some human melanomas. 8183937 1994
CUI: C0151779
Disease: Cutaneous Melanoma
Cutaneous Melanoma 		0.010 Biomarker disease BEFREE We investigated the therapeutic potential of employing antisense oligodeoxynucleotides to target the disruption of MYB, a gene which has been postulated to play a pathogenetic role in cutaneous melanoma. 8183937 1994
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.040 AlteredExpression disease BEFREE Direct dependence of these effects on the kinase activity is proven in experiments in which expression of c-MYB protein in fibroblast-like cells or downregulation of c-MYB expression resulting in analogous inhibition of CML cell proliferation does not result in the same changes. 8195713 1994
CUI: C0023479
Disease: Acute myelomonocytic leukemia
Acute myelomonocytic leukemia 		0.030 AlteredExpression disease BEFREE Induction of differentiation and down-regulation of c-myb gene expression in ML-1 human myeloblastic leukemia cells by the clinically effective anti-leukemia agent meisoindigo. 8630096 1996
CUI: C2242826
Disease: Myeloblastic leukemia
Myeloblastic leukemia 		0.010 AlteredExpression disease BEFREE Induction of differentiation and down-regulation of c-myb gene expression in ML-1 human myeloblastic leukemia cells by the clinically effective anti-leukemia agent meisoindigo. 8630096 1996
CUI: C0011644
Disease: Scleroderma
Scleroderma 		0.010 Biomarker disease BEFREE These data suggest that the B-myb and c-myb genes may play a role in scleroderma fibroblast proliferation and function. 8752671 1996
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.010 Biomarker disease BEFREE These data suggest that the B-myb and c-myb genes may play a role in scleroderma fibroblast proliferation and function. 8752671 1996
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE In vitro translation and immuno-precipitation analysis of the cRNAs derived from the ABPL-1, ABPL-2 and ABPL-4 cDNAs show the synthesis of protein products that were identical to Myb proteins produced by these tumors in vivo. 8808693 1996
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 Biomarker phenotype BEFREE To date, v-myb is the only myb gene directly implicated in tumorigenesis, a property attributed to its transactivating ability. 9096377 1997
CUI: C0025202
Disease: melanoma
melanoma 		0.060 Biomarker disease BEFREE We suggest that c-MYB contributes to FGF-2-mediated autocrine growth of melanomas by indirectly regulating the FGF-2 promoter. 9372243 1997
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.040 AlteredExpression disease BEFREE We detected truncated c-MYB mRNA (2.0 kb) and c-Myb protein (55 kDa) in the TK-6 cell line, which was established from a patient with chronic myelogenous leukemia in T cell blast crisis. 9737692 1998
CUI: C0005699
Disease: Blast Phase
Blast Phase 		0.030 AlteredExpression disease BEFREE We detected truncated c-MYB mRNA (2.0 kb) and c-Myb protein (55 kDa) in the TK-6 cell line, which was established from a patient with chronic myelogenous leukemia in T cell blast crisis. 9737692 1998
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 Biomarker phenotype BEFREE Reassessing the role of C-MYB in tumorigenesis. 10378698 1999
CUI: C0376544
Disease: Hematopoietic Neoplasms
Hematopoietic Neoplasms 		0.020 AlteredExpression group BEFREE Hematopoietic tumors in both humans and mice frequently up-regulate expression of the c-myb gene, but it is unclear whether this is a cause or a consequence of the leukemic state. 10378698 1999
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE Nevertheless, as will be touched on below, other malignancies have also been examined as models for Myb targeted therapy with some surprisingly encouraging results. 10378701 1999
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE In addition, in a multivariate Cox regression analysis that included myb gene expression, MYCN status, age at diagnosis, and tumor staging, MYCN amplification and B-myb expression were independently associated to an increased risk (P < 0.01 and P = 0.015, respectively). 10416595 1999
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.050 AlteredExpression disease BEFREE All of the myb genes were frequently expressed in neuroblastoma tumors. 10416595 1999
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.050 AlteredExpression disease BEFREE All of the myb genes were frequently expressed in neuroblastoma tumors. 10416595 1999
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.050 AlteredExpression disease BEFREE All of the myb genes were frequently expressed in neuroblastoma tumors. 10416595 1999
CUI: C2936380
Disease: Neointima
Neointima 		0.200 Therapeutic disease RGD Adenovirus-mediated expression of a ribozyme to c-myb mRNA inhibits smooth muscle cell proliferation and neointima formation in vivo. 10438864 1999