|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
MYC rearrangements were detected in 3 of 38 (8%) transformed lymphomas and in 1 of 58 (2%) control follicular lymphomas.
|
1638027 |
1992 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A third case showed a major rearrangement of c-myc gene, with truncation within its first intron, similar to those observed in sporadic Burkitt's and in acquired immunodeficiency-associated lymphomas.
|
1713514 |
1991 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
From these studies it is inferred that secondary dysregulation of a c-MYC in a lymphoma tumor carrying dysregulated BCL2 gene leads to rapid progression to high grade disease.
|
1992441 |
1991 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Similar to endemic and sporadic Burkitt's lymphoma, monoclonal B-lymphoma subsets were found to be infected with Epstein-Barr virus (EBV) or have c-myc gene rearrangements, suggesting a role for EBV infection or chromosomal translocation in a subset of AIDS NHLs.
|
2022596 |
1991 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunoglobulin and Myc gene structure in lymphnode biopsies from HIV-positive patients with LAS and lymphoma.
|
2386973 |
1990 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Among the regions affected, only the immunoglobulin heavy-chain gene MYC, and BCL2, have thus far been associated with lymphoma.
|
2506953 |
1989 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Nucleotide sequence of the first exon of the rat c-myc gene: proviral insertions in murine leukemia virus-induced lymphomas do not affect exon 1.
|
3284178 |
1988 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The c-myc gene was found to be rearranged in two lymphomas, an African Burkitt's lymphoma and a non-Hodgkins lymphoma in leukemic phase.
|
6330529 |
1984 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Although with the majority of the specimens there was no obvious correlation between the morphologic cell type of lymphoma/leukemia and the c-onc RNA levels, interestingly two of the three samples diagnosed as chronic lymphocytic leukemia, B-cell type, showed considerably increased transcription of the c-myc gene relative to the other B-cell neoplasms.
|
6603429 |
1983 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Lymphomas were also evaluated for the presence of Epstein-Barr virus (EBV) DNA sequences and c-myc gene rearrangements.
|
7535586 |
1995 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We observed that in vivo phosphorylation of Thr-58 was absent in a lymphoma cell line with a mutant MYC allele containing a missense mutation flanking codon 58.
|
7623799 |
1995 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Translocations between the endogenous c-myc gene and immunoglobulin loci, e.g., t(12;15), are common in lymphomas arising in the bcl-2-Ig mice.
|
7698223 |
1995 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Mutations were also found in other de novo non-AIDS, non-Burkitt's aggressive lymphomas with MYC rearrangements.
|
8012955 |
1994 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The c-myc gene is implicated in hematopoietic malignancies on the basis of its frequent deregulation in naturally occurring leukemias and lymphomas.
|
8260894 |
1993 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Rearrangements of the c-MYC proto-oncogene and mutations of the p53 tumor suppressor gene have also been documented in these lymphomas.
|
8274734 |
1994 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
All four KSHV-negative lymphomatous effusions exhibited Burkitt or Burkitt-like morphology and c-myc gene rearrangements and, therefore, appeared to be Burkitt-type lymphomas occurring in the body cavities.
|
8695812 |
1996 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The appearance of malignant lymphoma is characterized by the presence of a monoclonal B-cell population displaying a variety of genetic lesions including Epstein-Barr virus (EBV) infections, c-myc gene rearrangement, bcl-6 gene rearrangement, ras gene mutations, and p53 gene mutations/deletions.
|
9044511 |
1997 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These results suggest that decreased expression of C-MYC and BCL2 may play a role in the molecular events that initiate and are responsible for the growth inhibition of Raji lymphoma xenografts by MP.
|
9169090 |
1997 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
By Southern blot analysis, none of the 54 MALT lymphomas but 2 of 36 nodal lymphomas had c-myc gene rearrangements.
|
9196434 |
1997 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The PELs share several features with acquired immunodeficiency syndrome (AIDS)-associated primary central nervous system lymphomas (1 degree CNS-L), including B-cell phenotype, infection with Epstein-Barr virus, and lack of c-myc gene rearrangements.
|
9484350 |
1998 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The unique B-cell genotype configuration and the C-MYC activation suggested that the cellular origin of this rare case of malignant lymphoma with a T-cell phenotype was quite immature lymphocytes.
|
9494610 |
1998 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, myc gene amplification appears to play a part in MLs but no correlation was found between EBV infection and myc gene amplification.
|
9610616 |
1998 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In particular, gastrointestinal (GI) lymphomas (5 of 18 cases, 28%) were affected by MYC rearrangements.
|
9787151 |
1998 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Mutation of Thr58 in lymphoma thus escapes this regulation resulting in accumulation of c-Myc protein, likely as part of the tumor progression.(Blood.2000;95:2104-2110)
|
10706881 |
2000 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We identified several genes, most of them involved in cell cycle regulation, that are over expressed in MYC induced lymphomas as well as MYC induced neuronal-like tumors.
|
11526483 |
2001 |