leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
By using probes specific for the c-mos and c-myc genes, we have analysed the genomic DNA from peripheral blood and bone marrow samples from 15 patients with various malignant myeloid diseases, including leukemia and myelodysplasia, and from one patient with non-Hodgkin's lymphoma, all of whom have trisomy for chromosome No.8.
|
4079453 |
1985 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Treatment with the DPY30-binding peptides significantly inhibited the growth of MLL-rearranged leukemia and other MYC-dependent hematologic cancer cells.
|
31251903 |
2019 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There were no mutations in the c-myc gene in any of the leukemia cell lines that could account for increased c-Myc stability.
|
16855632 |
2006 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we describe a novel oral active small molecule analog of berbamine, tosyl chloride-berbamine (TCB), that efficiently eliminates MYC-positive leukemia in vitro and in vivo.
|
31247466 |
2019 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have shown that the c-Myc promoter quadruplex-forming sequence Pu-27 selectively kills transformed cells (Sedoris, K. C., Thomas, S. D., Clarkson, C. R., Muench, D., Islam, A., Singh, R., and Miller, D. M. (2012) Genomic c-Myc quadruplex DNA selectively kills leukemia.Mol.Cancer Ther.11, 66-76).
|
24464582 |
2014 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, it was demonstrated that, compared with several normal and leukaemia human cells, DNA sequences representing the human homologue of the onc gene of the avian myelocytomatosis virus (MC29), the so-called c-myc gene, were amplified in HL-60 cells.
|
6580529 |
1984 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.
|
23079661 |
2012 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Dual-hit lymphoma/leukemia is a rare but distinct mature B-cell neoplasm with an extremely poor prognosis characterized by frequent extranodal involvement and central nervous system progression with either of the translocation partners of MYC.
|
19535347 |
2009 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Transgenic mice expressing two potent collaborating oncogenes in the germ line (CD2-MYC, -Runx2) develop rapid onset tumours that can be accelerated and rendered polyclonal by neonatal Moloney murine leukaemia virus (MoMLV) infection.
|
24586197 |
2014 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Transformation from follicular lymphoma to high-grade B-cell lymphoma/leukemia with additional t(2;8)(p12;q24), with inverse expressions of c-MYC and BCL-2, and light-chain switch.
|
19351371 |
2009 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we provide evidence showing that HHT inhibits the activity of leukemia-initiating cells (Lin<sup>-</sup>/Sca-1<sup>-</sup>/c-kit<sup>+</sup>; LICs) in a t(8;21) murine leukemia model and exerts a down-regulating effect on MYC pathway genes in human t(8;21) leukemia cells (Kasumi-1).
|
30659143 |
2019 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This newly discovered JAK/STAT-MYC-biosynthesis axis may provide opportunities for the development of novel therapeutic strategies in treating this subtype of leukemia.
|
29148541 |
2018 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response.
|
29743725 |
2018 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have previously shown that all six members of the anti-apoptotic BCL2 gene family can cooperate with (myelocytomatosis oncogene) MYC in a mouse model of leukemia, but three of them are significantly less potent contributors to leukemogenicity than the other three.
|
22233804 |
2012 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Convergence of the ZMIZ1 and NOTCH1 pathways at C-MYC in acute T lymphoblastic leukemias.
|
23161489 |
2013 |
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have used a monoclonal antibody for the c-myc protein to investigate the level of expression in 11 patients with T-PLL and two with Sezary cell leukemia and compared it with levels seen in normal lymphocytes.
|
7564512 |
1995 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
c-MYC and reactive oxygen species play roles in tetrandrine-induced leukemia differentiation.
|
29700286 |
2018 |
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Sustained expression of the MYC transgene culminated in the formation of malignant T cell lymphomas and acute myleoid leukemias.
|
10488335 |
1999 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Multiple translocation partner genes are well known for leukaemia such as MYC, MLL, RARA, ALK, and RUNX1.
|
26871368 |
2016 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Methylation status within exon 3 of the c-myc gene as a prognostic marker in myeloma and leukaemia.
|
7680737 |
1993 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Concomitant and successive amplifications of MYC in APL-like leukemia.
|
20113841 |
2010 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The induction of BIMin the MYC- and RAS-driven leukemia is mediated by the downregulation of miR-17-92.
|
27095570 |
2016 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Nucleotide sequence of the first exon of the rat c-myc gene: proviral insertions in murine leukemia virus-induced lymphomas do not affect exon 1.
|
3284178 |
1988 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A pediatric B lineage leukemia with coincident MYC and MLL translocations.
|
20829716 |
2011 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Translocations involving an overexpressed c-myc gene are also found in AIDS-associated lymphoma or in T cell leukaemias, or they develop during tumour progression of a low grade B cell malignancy into a high grade B cell tumour in an additional cytogenetic change.
|
8142618 |
1993 |