Adult Medulloblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
For pediatric CNS neoplasms, only medulloblastoma has been investigated in adequate numbers; a small percentage exhibit amplification of either the N-myc or c-myc genes.
|
1374522 |
1992 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These observations demonstrate that the c-myc gene is often amplified and/or rearranged in human medulloblastomas and suggest that amplification of this gene provides a growth advantage for medulloblastoma cells in vitro and in vivo.
|
2180567 |
1990 |
Adult Medulloblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Repair analysis of 4-hydroperoxycyclophosphamide-induced DNA interstrand crosslinking in the c-myc gene in 4-hydroperoxycyclophosphamide-sensitive and -resistant medulloblastoma cell lines.
|
8529284 |
1996 |
Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study was to determine the incidence of c-Myc protein expression in medulloblastoma/primitive neuroectodermal tumor (MB/PNET) and to identify mechanisms in addition to c-myc gene amplification that lead to increased protein expression.
|
9482408 |
1998 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We describe amplification of the MYCC oncogene in a medulloblastoma with aggressive clinical behavior.
|
10643003 |
1999 |
Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
C-MYC expression in medulloblastoma and its prognostic value.
|
11008200 |
2000 |
Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MYC messenger RNA expression predicts survival outcome in childhood primitive neuroectodermal tumor/medulloblastoma.
|
11489822 |
2001 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group.
|
11958658 |
2002 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
There is a strong association between anaplastic/large-cell tumours and MYC amplification, which has previously been linked with aggressive disease, but associations between abnormalities on chromosome 17 and anaplastic/large-cell MBs and between abnormalities in the shh/PTCH pathway and the desmoplastic variant are more controversial.
|
12175339 |
2002 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Identical analyses were performed in a panel of medulloblastoma cell lines to identify c-Myc targets and to determine the extent to which N-Myc targets and c-Myc targets were shared.
|
12910530 |
2003 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
c-Myc promoter activation in medulloblastoma.
|
12941792 |
2003 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Both anaplasia and increased c-myc gene expression have been shown to be negative prognostic indicators for survival in medulloblastoma patients. myc gene amplification has been identified in many large cell/anaplastic medulloblastoma, but no causative link between c-myc and anaplastic changes has been established.
|
16423996 |
2006 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
MXI1 mutation appears to play a role in the pathogenesis of a small subset of cases, and suggests an alternative mechanism to MYC amplification for disruption of the MYC/MAD/MAX network in medulloblastoma.
|
17102621 |
2006 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Amplifications in this series included MYCL, MYCN and MYC previously implicated in medulloblastoma pathogenesis, as well as novel amplicons on chromosomes 2, 4, 11 and 12.
|
17465989 |
2007 |
Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical and molecular data (c-myc gene amplification and the presence of isochromosome 17q) support the contention that this histologically diverse tumor represents a pattern of medulloblastoma with striated muscle and pigmented epithelial differentiation, rather than a teratoma or a cerebellar variant of melanotic neuroectodermal tumor of infancy ('progonoma').
|
18317693 |
2008 |
Adult Medulloblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Since FISH could easily detect most cases in the moderate-to-high myc gene amplification (> 5-fold CN) group, the FISH assay has utility in detecting subsets of MB with poorer prognosis.
|
19119907 |
2009 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
To study the role of c-MYC in MB biology, we down-regulated c-MYC expression by using small interfering RNA (siRNA) and investigated changes in cellular proliferation, cell cycle analysis, apoptosis, telomere maintenance, and response to ionizing radiation (IR) and chemotherapeutics in a representative panel of human MB cell lines expressing different levels of c-MYC (DAOY wild-type, DAOY transfected with the empty vector, DAOY transfected with c-MYC, D341, and D425).
|
19134217 |
2009 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.
|
19270706 |
2009 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Additional analysis by interphase fluorescence in situ hybridisation (iFISH), PCR-based mapping and SNP-array revealed this novel amplification at 8q24.22-q24.23 is independent of MYC amplification at 8q24.21, and is unique to medulloblastoma in over 800 cancer cell lines assessed from different tumour types, suggesting it contains key genes specifically involved in medulloblastoma development.
|
19584924 |
2009 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Low-level copy number changes of MYC genes have a prognostic impact in medulloblastoma.
|
20607354 |
2011 |
Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The association of clinically aggressive medulloblastoma with MYC expression, large cell/anaplastic change and high levels of photoreceptor differentiation transcripts has also been noted in several studies.
|
21129063 |
2011 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
It is known that overexpression and/or amplification of the MYC oncogene is associated with poor clinical outcome, but the molecular mechanisms and the MYC downstream effectors in MB remain still elusive.
|
21317922 |
2011 |
Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
c-MYC expression sensitizes medulloblastoma cells to radio- and chemotherapy and has no impact on response in medulloblastoma patients.
|
21324178 |
2011 |
Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Antisense-based knockdown of miR-512-5p (mature sequence of miR-512-2) resulted in significant upregulation of MYCC expression in HeLa and A549 cells, while forced overexpression of miR-512-2 in medulloblastoma/PNET cell lines DAOY, UW-228-2, PFSK resulted in the downregulation of MYCC protein.
|
21793975 |
2012 |
Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our data suggest an important functional interaction between OTX2 and MYC in regulating gene expression in medulloblastoma.
|
22016811 |
2011 |