Childhood Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These observations demonstrate that the c-myc gene is often amplified and/or rearranged in human medulloblastomas and suggest that amplification of this gene provides a growth advantage for medulloblastoma cells in vitro and in vivo.
|
2180567 |
1990 |
Childhood Medulloblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
For pediatric CNS neoplasms, only medulloblastoma has been investigated in adequate numbers; a small percentage exhibit amplification of either the N-myc or c-myc genes.
|
1374522 |
1992 |
Childhood Medulloblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Repair analysis of 4-hydroperoxycyclophosphamide-induced DNA interstrand crosslinking in the c-myc gene in 4-hydroperoxycyclophosphamide-sensitive and -resistant medulloblastoma cell lines.
|
8529284 |
1996 |
Childhood Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of the c-Myc protein in childhood medulloblastoma.
|
9482408 |
1998 |
Childhood Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We describe amplification of the MYCC oncogene in a medulloblastoma with aggressive clinical behavior.
|
10643003 |
1999 |
Childhood Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
C-MYC expression in medulloblastoma and its prognostic value.
|
11008200 |
2000 |
Childhood Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MYC messenger RNA expression predicts survival outcome in childhood primitive neuroectodermal tumor/medulloblastoma.
|
11489822 |
2001 |
Childhood Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
There is a strong association between anaplastic/large-cell tumours and MYC amplification, which has previously been linked with aggressive disease, but associations between abnormalities on chromosome 17 and anaplastic/large-cell MBs and between abnormalities in the shh/PTCH pathway and the desmoplastic variant are more controversial.
|
12175339 |
2002 |
Childhood Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group.
|
11958658 |
2002 |
Childhood Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
c-Myc promoter activation in medulloblastoma.
|
12941792 |
2003 |
Childhood Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Identical analyses were performed in a panel of medulloblastoma cell lines to identify c-Myc targets and to determine the extent to which N-Myc targets and c-Myc targets were shared.
|
12910530 |
2003 |
Childhood Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Both anaplasia and increased c-myc gene expression have been shown to be negative prognostic indicators for survival in medulloblastoma patients. myc gene amplification has been identified in many large cell/anaplastic medulloblastoma, but no causative link between c-myc and anaplastic changes has been established.
|
16423996 |
2006 |
Childhood Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
MXI1 mutation appears to play a role in the pathogenesis of a small subset of cases, and suggests an alternative mechanism to MYC amplification for disruption of the MYC/MAD/MAX network in medulloblastoma.
|
17102621 |
2006 |
Childhood Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Amplifications in this series included MYCL, MYCN and MYC previously implicated in medulloblastoma pathogenesis, as well as novel amplicons on chromosomes 2, 4, 11 and 12.
|
17465989 |
2007 |
Childhood Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical and molecular data (c-myc gene amplification and the presence of isochromosome 17q) support the contention that this histologically diverse tumor represents a pattern of medulloblastoma with striated muscle and pigmented epithelial differentiation, rather than a teratoma or a cerebellar variant of melanotic neuroectodermal tumor of infancy ('progonoma').
|
18317693 |
2008 |
Childhood Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Additional analysis by interphase fluorescence in situ hybridisation (iFISH), PCR-based mapping and SNP-array revealed this novel amplification at 8q24.22-q24.23 is independent of MYC amplification at 8q24.21, and is unique to medulloblastoma in over 800 cancer cell lines assessed from different tumour types, suggesting it contains key genes specifically involved in medulloblastoma development.
|
19584924 |
2009 |
Childhood Medulloblastoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.
|
19270706 |
2009 |
Childhood Medulloblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Since FISH could easily detect most cases in the moderate-to-high myc gene amplification (> 5-fold CN) group, the FISH assay has utility in detecting subsets of MB with poorer prognosis.
|
19119907 |
2009 |
Childhood Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci.
|
19255330 |
2009 |
Childhood Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
To study the role of c-MYC in MB biology, we down-regulated c-MYC expression by using small interfering RNA (siRNA) and investigated changes in cellular proliferation, cell cycle analysis, apoptosis, telomere maintenance, and response to ionizing radiation (IR) and chemotherapeutics in a representative panel of human MB cell lines expressing different levels of c-MYC (DAOY wild-type, DAOY transfected with the empty vector, DAOY transfected with c-MYC, D341, and D425).
|
19134217 |
2009 |
Childhood Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our data suggest an important functional interaction between OTX2 and MYC in regulating gene expression in medulloblastoma.
|
22016811 |
2011 |
Childhood Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The association of clinically aggressive medulloblastoma with MYC expression, large cell/anaplastic change and high levels of photoreceptor differentiation transcripts has also been noted in several studies.
|
21129063 |
2011 |
Childhood Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
It is known that overexpression and/or amplification of the MYC oncogene is associated with poor clinical outcome, but the molecular mechanisms and the MYC downstream effectors in MB remain still elusive.
|
21317922 |
2011 |
Childhood Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
As we failed to show evidence for such an effect on postoperative residual tumors when analyzed by imaging, additional investigations in xenografts and larger MB cohorts may help to define the exact function of c-MYC in modulating response to treatment.
|
21324178 |
2011 |
Childhood Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Survival analysis has clearly shown that MYC copy number increases are associated with lowered event-free survival and overall survival in MB.
|
20607354 |
2011 |