Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Patients with both MYC and BCL2 CNA had similar outcomes to those with classic double hit lymphoma or protein double expression lymphoma (MYC and BCL2/BCL6 coexpression).
|
26158410 |
2015 |
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results provide a baseline for MYC protein expression in lymphomas and indicate that its expression is not specific to lymphoma subtypes, cell lineage, or expected clinical behavior and is highly variable.
|
25581730 |
2015 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sensitisation of c-MYC-induced B-lymphoma cells to apoptosis by ATF2.
|
23416976 |
2014 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we provide biological insight on the function of MYC-regulated miRNAs, the mechanisms of MYC-induced miRNA repression, and the complicated feedback circuitry underlying lymphoma progression, as well as potential therapeutic targets in aggressive B-cell lymphomas.
|
24394940 |
2014 |
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MYC activation results in widespread repression of micro-RNA (miRNA) expression and associated with lymphoma aggressive progression.
|
23538750 |
2013 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Specifically, following regulatory network analysis in human B-cells, we identify a novel role of the STK38 kinase as a regulator of MYC activity and a candidate target for abrogating tumorigenesis in MYC-addicted lymphoma.
|
23178486 |
2013 |
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Isolated BCL2 and MYC rearrangements were not predictive of outcome in our patients as a whole, but only in those with the germinal center subtype of lymphoma.
|
22929980 |
2013 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We use this to model oncogene addiction in MYC-induced lymphoma, osteosarcoma, and hepatocellular carcinoma.
|
23573174 |
2013 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, picolog was highly potent at 100 micrograms/kg and well tolerated at doses ranging from 100 micrograms/kg to 1 milligram/kg in vivo for the treatment of our aggressive model of MYC-induced lymphoma.
|
22308267 |
2012 |
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Both primary breast lymphoma and lymphoma with concurrent BCL2-IGH and MYC translocations are rare and are primarily seen in adult patients.
|
21491965 |
2012 |
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
They also negatively correlated with the overall survival of patients with lymphoma in the same way that MYC levels do.
|
22546857 |
2012 |
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our mathematical model could be generalized to different imaging methods (computed tomography and bioluminescence imaging), different oncogenes (K-ras(G12D) and MYC), and several tumor types (lung and lymphoma).
|
21974937 |
2011 |
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of BET bromodomain-promoter interactions and subsequent reduction of MYC transcript and protein levels resulted in G(1) arrest and extensive apoptosis in a variety of leukemia and lymphoma cell lines.
|
21949397 |
2011 |
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Analysis of cancer expression databases also indicated a correlation between MYC and SKP2 expression in lymphoma.
|
21245140 |
2011 |
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This lymphoma usually shows MYC rearrangements with non-IGH genes in the setting of a complex karyotype possibly involving BCL2 and, less frequently, BCL6 rearrangements.
|
21156254 |
2010 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, MYC possesses nontranscriptional functions other than transcriptional controls on genes regulating cell growth and may also influence the lymphoma microenvironment.
|
20817505 |
2010 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, we show that the ESC program is correlated with transcriptional programs maintaining tumor phenotype in transgenic MYC-driven mouse models of lymphoma.
|
19636063 |
2009 |
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The importance of miRNAs in MYC-driven tumorigenesis has been enlightened by studying cell line and murine lymphoma models with conditional expression of MYC.
|
19197161 |
2009 |
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Dual-hit lymphoma/leukemia is a rare but distinct mature B-cell neoplasm with an extremely poor prognosis characterized by frequent extranodal involvement and central nervous system progression with either of the translocation partners of MYC.
|
19535347 |
2009 |
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our method can quantify amounts of MYC oncoprotein and B cell lymphoma protein-2 (BCL2) in Burkitt's and follicular lymphoma; identify changes in activation of extracellular signal-related kinases-1 (ERK1) and ERK2, mitogen-activated kinase-1 (MEK), signal transducer and activator of transcription protein-3 (STAT3) and STAT5, c-Jun N-terminal kinase (JNK) and caspase-3 in imatinib-treated chronic myelogeneous leukemia (CML) cells; measure an unanticipated change in the phosphorylation of an ERK2 isomer in individuals with CML who responded to imatinib; and detect a decrease in STAT3 and STAT5 phosphorylation in individuals with lymphoma who were treated with atorvastatin.
|
19363496 |
2009 |
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We report a unique KSHV(-) EBV(-) post-transplant effusion lymphoma associated with serum paraproteins, occurring in an HIV(-) individual, which had cytologic features and phenotype similar to PEL, and displayed a complex karyotype including isochromosome 12p and translocation t(8;22), resulting in rearrangement of c-MYC.
|
19337983 |
2009 |
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We suggest that, concordant with the WHO classification to be published in 2008, the diagnosis of BL should be restricted to cases with expression of CD10 and BCL6, absence or very weak expression of BCL2 protein, a homogeneously very high proliferation index and a proven IG-MYC translocation without evidence of a chromosomal translocation typical for other lymphoma entities.
|
18923440 |
2009 |
Childhood Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To further analyze the impact of MYC-regulated miRNAs, we investigated a murine lymphoma model harboring the MYC transgene in a Tet-off system to control its expression.
|
18713946 |
2008 |
Childhood Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To validate the role of gene signatures associated with MYC in human tumorigenesis, we examined the expression of human homologs in 273 published human lymphoma microarray datasets in Affymetrix U133A format.
|
18535662 |
2008 |
Childhood Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To examine how the MYC and K-ras(G12D) oncogenes cooperate for the initiation and maintenance of tumorigenesis, we generated double conditional transgenic tumor models of lung adenocarcinoma and lymphoma.
|
18461184 |
2008 |