|
Ischemic stroke
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, inhibition of PERK with the specific inhibitor GSK2606414 markedly attenuated the Hes1 knockdown-induced apoptosis and the increased cerebral infarction as well as the worsened neurological outcome following tMCAO, implying that the protection of Hes1 against ischemic stroke is associated with the amelioration of ER stress via modulating the PERK/eIF2α/ATF4/CHOP signaling pathway.
|
31309426 |
2020 |
|
Brain Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
ATF4 contributes to autophagy and survival in sunitinib treated brain tumor initiating cells (BTICs).
|
30719230 |
2019 |
|
Burkitt Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Artesunate activates the ATF4-CHOP-CHAC1 pathway and affects ferroptosis in Burkitt's Lymphoma.
|
31537387 |
2019 |
|
Cerebral Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Parkin-Dependent Mitophagy is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats.
|
31416289 |
2019 |
|
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mice with disruption of Atf4 specifically in intestinal epithelial cells (Atf4ΔIEC mice) and Atf4-floxed mice (controls) were given dextran sodium sulfate (DSS) to induce colitis.
|
30452920 |
2019 |
|
Ulcerative Colitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Levels of ATF4 are decreased in inflamed intestinal mucosa from patients with active CD or UC.
|
30452920 |
2019 |
|
Crohn Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Levels of ATF4 are decreased in inflamed intestinal mucosa from patients with active CD or UC.
|
30452920 |
2019 |
|
Japanese Encephalitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we report that JEV infection activates the PERK-ATF4-CHOP apoptosis pathway both <i>in vitro</i> and <i>in vivo</i> PERK activation also promotes the formation of stress granule, which in turn represses JEV-induced apoptosis.
|
31189710 |
2019 |
|
Enterocolitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Atf4ΔIEC mice developed spontaneous enterocolitis and colitis of greater severity than control mice after administration of DSS.
|
30452920 |
2019 |
|
Hepatitis C
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Liraglutide decreased the cell viability of HCV RNA at an optimum concentration of 120 μg/mL, activated the 5' adenosine monophosphate-activated protein kinase (AMPK) and the phosphorylated- transducer of regulated cyclic adenosine monophosphate (CAMP) response element-binding protein 2 (TORC2), thereby decreasing the cell viability of phosphoenolpyruvate carboxykinase (PEPCK) and G6pase RNA Therefore, we conclude that liraglutide can inhibit HCV replication via an AMPK/TORC2-dependent pathway.
|
31540136 |
2019 |
|
Inflammatory Bowel Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
ATF4 might therefore be a target for the treatment of IBD.
|
30452920 |
2019 |
|
Periodontitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MicroRNA-214 contributes to regulation of necroptosis via targeting ATF4 in diabetes-associated periodontitis.
|
31090954 |
2019 |
|
West Nile Fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
While LGP2 functions to modulate inflammatory signaling, RIG-I and MDA5 together are essential for M1 macrophage polarization in vivo and the control of WNV infection through potential downstream control of ATF4 and SMAD4 to regulate target gene expression for cell polarization.
|
31409781 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we provide evidence for ATF4 activation across multiple stages and molecular subtypes of human lung adenocarcinoma.
|
31551255 |
2019 |
|
Zika Virus Infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
Similarly, Zika virus (MR766) infection of SH-SY5Y showed a titer-dependent increase in ER stress-signaling transcripts; however, this was absent or diminished for DDIT4 and ATF4, respectively, suggestive of differences in the induction of stress-response transcripts between flaviviruses.
|
31292858 |
2019 |
|
Adult Burkitt Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Artesunate activates the ATF4-CHOP-CHAC1 pathway and affects ferroptosis in Burkitt's Lymphoma.
|
31537387 |
2019 |
|
Childhood Burkitt Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Artesunate activates the ATF4-CHOP-CHAC1 pathway and affects ferroptosis in Burkitt's Lymphoma.
|
31537387 |
2019 |
|
Jaw Keratocyst
|
0.010 |
Biomarker
|
disease |
BEFREE |
Elevated ATF4 Expression in Odontogenic Keratocysts Epithelia: Potential Involvement in Tissue Hypoxia and Stromal M2 Macrophage Infiltration.
|
31424999 |
2019 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data support that one of the canonical UPR branches, through ATF4 and its target gene FAM129A, is required for PCa growth and thus may serve as a novel therapeutic target.
|
31312022 |
2019 |
|
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data support that one of the canonical UPR branches, through ATF4 and its target gene FAM129A, is required for PCa growth and thus may serve as a novel therapeutic target.
|
31312022 |
2019 |
|
FRIEDREICH ATAXIA 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
In human cells, hypoxia restores steady-state levels of Fe-S clusters and normalizes ATF4, NRF2, and IRP2 signaling events associated with FRDA.
|
31031004 |
2019 |
|
HER2-positive carcinoma of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, upregulated expression of ATF4 was found in HER2-positive breast cancer specimens.
|
31064130 |
2019 |
|
HER2-negative breast cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here we demonstrate that methionine restriction induces eIF2α phosphorylation and enhances ATF4 gene expression and protein levels of ATF4 and Sestrin-2 in triple (ER/PR/HER2)-negative breast cancer (TNBC) cells.
|
31497357 |
2019 |
|
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
The protein level of PDL1 was significantly correlated with those of IRF1, eIF2<i>α</i>, and ATF4 in the tissues of all subjects and the subgroup of squamous cell carcinoma but not in the normal tissue of adenocarcinoma.
|
30305853 |
2018 |
|
Arteriosclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
As an in vitro model of atherosclerosis, rat smooth muscle cells (SMCs) were treated with oxygenized low-density lipoprotein (ox-LDL), which significantly elevated the levels of ER markers glucose-regulated protein78 (GRP78), protein kinase R-like ER kinase (PERK), phosphorylated eukaryotic translation initiation factor α subunit (p-eIF2α), activating transcription factor-4 (ATF-4), CEBP homologous protein (CHOP) and 4-HNE in the cells.
|
28858301 |
2018 |