|
Adenoid Cystic Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We show that the t(6;9)(q22-23;p23-24) translocation in adenoid cystic carcinomas (ACC) of the breast and head and neck consistently results in fusions encoding chimeric transcripts predominantly consisting of MYB exon 14 linked to the last coding exon(s) of NFIB.
|
19841262 |
2009 |
|
Adenoid Cystic Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
For instance, secretory carcinomas of the breast consistently harbour the t(12;15) translocation that leads to the formation of the ETV6-NTRK3 fusion gene, adenoid cystic carcinomas consistently display the t(6;9) MYB-NFIB translocation and lobular carcinomas consistently show inactivation of the CDH1 gene through multiple molecular mechanisms.
|
20452298 |
2010 |
|
Adenoid Cystic Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: Incidence, variability, and clinicopathologic significance.
|
20702610 |
2010 |
|
Adenoid Cystic Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A balanced translocation between MYB and NFIB is present in 49% of adenoid cystic carcinomas but is not identified in other salivary gland tumors or nonsalivary gland neoplasms.
|
21164292 |
2011 |
|
Adenoid Cystic Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms.
|
21572406 |
2011 |
|
Adenoid Cystic Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The MYB-NFIB gene fusion-a novel genetic link between adenoid cystic carcinoma and dermal cylindroma.
|
21618541 |
2011 |
|
Adenoid Cystic Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Clinically significant copy number alterations and complex rearrangements of MYB and NFIB in head and neck adenoid cystic carcinoma.
|
22505352 |
2012 |
|
Adenoid Cystic Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Because of the well-known morphologic similarities between PLGA and adenoid cystic carcinoma (ACC) we also analyzed all tumors for expression of the recently identified ACC-associated MYB-NFIB gene fusion. aCGH analysis revealed that the PLGA genome contains comparatively few copy number alterations (CNAs).
|
21901247 |
2012 |
|
Adenoid Cystic Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The MYB-NFIB fusion gene was detected in all but one AdCC. aCGH analysis demonstrated a relatively low number of copy number aberrations and a lack of recurrent amplifications in breast AdCCs.
|
22015727 |
2012 |
|
Adenoid Cystic Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The majority of adenoid cystic carcinomas (AdCCs), regardless of anatomical site, harbour the MYB-NFIB fusion gene.
|
23398044 |
2013 |
|
Adenoid Cystic Carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
The mutational landscape of adenoid cystic carcinoma.
|
23685749 |
2013 |
|
Adenoid Cystic Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To investigate genetic alterations in lacrimal gland adenoid cystic carcinomas (ACCs) with emphasis on the MYB-NFIB fusion oncogene and its downstream targets, MYB rearrangements, and copy number alterations in relation to clinical data and survival.
|
23725736 |
2013 |
|
Adenoid Cystic Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The defining molecular feature of adenoid cystic carcinoma is the presence of a recurrent chromosomal translocation, t(6; 9) (q22-23; p23-24), with the fusion transcript involving the genes MYB and NFIB.
|
23222122 |
2013 |
|
Adenoid Cystic Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Adenoid cystic carcinomas (ACCs) from various anatomical sites harbor a translocation t(6;9)(q22-23;p23-24), resulting in MYB-NFIB gene fusion.
|
25217885 |
2014 |
|
Adenoid Cystic Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data further demonstrated that the MYB/NFIB translocation is not necessarily an early event or fundamental for the progression to adenoid cystic carcinoma with high-grade transformation.
|
24732452 |
2014 |
|
Adenoid Cystic Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A significant portion of adenoid cystic carcinoma (ACC) cases are characterized by a t(6;9)(q22-23;p23-24) translocation that originates a MYB-NFIB fusion oncogene.
|
26309189 |
2015 |
|
Adenoid Cystic Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Adenoid cystic carcinoma (AdCC) is a rare type of triple-negative breast cancer (TNBC) characterized by the presence of the MYB-NFIB fusion gene.
|
26095796 |
2015 |
|
Adenoid Cystic Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Moreover, MYB-NFIB and EWSR1-ATF1 gene fusions were shown to be specifically found in cases of adenoid cystic carcinomas and hyalinizing clear cell carcinomas, respectively, in the context of salivary gland tumors, becoming reliable diagnostic tools for these entities and potential therapeutic targets for future therapeutic protocols.
|
25990369 |
2016 |
|
Adenoid Cystic Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Novel MYBL1 Gene Rearrangements with Recurrent MYBL1-NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations.
|
26631609 |
2016 |
|
Adenoid Cystic Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The MYB-NFIB fusion gene was detected in both adenoid cystic carcinomas and their associated high-grade triple-negative breast cancer components.
|
27491809 |
2016 |
|
Adenoid Cystic Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A majority of adenoid cystic carcinomas (AdCC)-rare tumors of the salivary gland and some other organs-have recently been found to be driven by chromosomal translocations resulting in MYB-NFIB fusions.
|
26851182 |
2016 |
|
Adenoid Cystic Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
CRTC1/MAML2 and MYB/NFIB were also analyzed in MEC and adenoid cystic carcinoma cases, respectively.
|
28139061 |
2017 |
|
Adenoid Cystic Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Breast adenoid cystic carcinoma (ACC) is a primary breast carcinoma that, like salivary gland ACC, displays the t(6;9) translocation resulting in the MYB-NFIB gene fusion and immunopositivity for MYB by immunohistochemistry (IHC).
|
28498281 |
2017 |
|
Adenoid Cystic Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
NFIB-associated gene rearrangement is a frequent genetic event in vulvar adenoid cystic carcinomas.
|
27662035 |
2017 |
|
Adenoid Cystic Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present study suggests that (1) nearly 90% of AdCCs may have gene alterations of either MYB, MYBL1 or NFIB, suggesting the diagnostic utility of the FISH assay, (2) MYB or MYBL1 gene splits may be associated with local aggressiveness of the tumours and overexpression of MYC, which is one of the oncogenic MYB/MYBL1 targets and (3) MYC overexpression may be a risk factor for disease-free survival in AdCC.
|
28594149 |
2017 |