Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A functional polymorphism of the NFKB1 promoter is not associated with ulcerative colitis in a Spanish population.
|
15905705 |
2005 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
An insertion/deletion polymorphism (-94ins/delATTG) in the promoter region of the NFKB1 gene correlates to an increased risk of ulcerative colitis, a known risk factor for colorectal cancer, but this polymorphism has not been studied in colorectal cancer patients.
|
17852842 |
2007 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis.
|
14613970 |
2004 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genotypes of nuclear factor (NF)-κB (NFKB1) NFκB -94ins/del (rs28362491); peroxisome proliferator-activated receptor (PPAR)-γ (PPARγ) PPARγ Pro12Ala (rs 1801282) and C1431T (rs 3856806); pregnane X receptor (PXR) (NR1I2) PXR A-24381C (rs1523127), C8055T (2276707), and A7635G (rs 6785049); and liver X receptor (LXR) (NR1H2) LXR T-rs1405655-C and T-rs2695121-C were assessed in a Danish case-control study of 327 Crohn's disease patients, 495 ulcerative colitis (UC) patients, and 779 healthy controls.
|
21245992 |
2011 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In addition, a polymorphism in the promoter region of the human NFKB1 gene was found to be associated with susceptibility to UC.
|
16313306 |
2005 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In addition, no significant interactions between the -94ins/delATTG NFKB1 polymorphism and polymorphisms within the IKBL and the IL-1RN genes, respectively, were found in CD or UC.
|
16804398 |
2006 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In previous studies the NFKBIA 3'UTR (untranslated region) AA genotype was associated with Crohn's disease (CD), while the NFKB1-94ins/delATTG mutation increased the risk for ulcerative colitis (UC).
|
18716880 |
2009 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Mutations involving the NF-kB pathway and epigenetic regulation were more common in ulcerative colitis-associated CRCs than in sporadic CRCs.
|
30794281 |
2019 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our results provide evidence that NFKB1 polymorphism rs72696119 was significantly associated with the development of UC.
|
23322997 |
2012 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of 3 candidate genes (PTPN22, NFkB1, and FcGRIIIA) were investigated in 649 IBD patients (343 with Crohn's disease [CD] and 306 with ulcerative colitis [UC]), 176 unaffected relatives, and 256 healthy controls.
|
17600378 |
2007 |
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis.
|
17124531 |
2006 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.
|
24971461 |
2014 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis indicated that the NF-κB1 -94ins/delATTG promoter polymorphism is a risk factor for UC but not CD.
|
22828805 |
2012 |
Ulcerative Colitis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Western blot studies showed an increased expression of the p50 and c-rel subunits of NF-kappa B; however, the most striking finding was an increased expression level of NF-kappa B p65 in patients with CD and UC.
|
9928378 |
1998 |
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
LHGDN |
[Activation of nuclear factor-kappaB and its relationship with cytokine gene expression in colonic mucosa of ulcerative colitis patients].
|
12133438 |
2002 |