|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor-associated macrophages (TAMs) with the M2-like phenotype are regulated by mainly NF-kB pathway including TBK1, which can influence tumor progression by secretion of proangiogenic factors such as vascular endothelial growth factor.
|
26416897 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NF-kappaB target genes promote tumor cell proliferation, survival, migration, inflammation, and angiogenesis.
|
17317814 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
NFKB1 mRNA levels were lower in both tumour and normal tissue from cancer patients (P<0.001) as compared to healthy individuals but we were unable to show association between NFKB1 -94ins/del genotype and NFKB1 mRNA levels.
|
23977225 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NF-κB1-deficient tumors exhibit 'normal' NF-κB activity, but a decreased protein level of Tpl2.
|
26300007 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
NFKB1 re-expression was found to partly abolish the tumor-suppressive effect of miR-508-3p in GC.
|
26801246 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
An NF-kappaB gene expression signature contributes to Kaposi's sarcoma virus vGPCR-induced direct and paracrine neoplasia.
|
17934524 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Analysis of tumor material indicates that the tumor suppressing effects of α-tomatine were accompanied by increased apoptosis and lower proliferation of tumor cells as well as reduced nuclear translocation of the p50 and p65 components of NF-κB.
|
23437404 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Analyzing paired tumor specimens from 12 patients, we found that NF-κB1 expression was increased in recurrent AI-resistant tumors as compared to the paired primary tumors before AI treatment.
|
23160924 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Annexin A2, a multifunctional tumor associated protein, promotes nuclear factor-kappa B (NF-κB) activation by interacting with NF-κB p50 subunit and facilitating its nuclear translocation.
|
29508276 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Antisense inhibition of the RelA subunit of NF-kappa B transcription factor (but not the NFKB1 subunit) causes pronounced inhibition of tumor cell growth in vitro and in vivo.
|
8615671 |
1996 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
B-2A13 cells showed increased sensitivity to 0.1 nM AFB1-induced neoplastic transformation and the formation of tumors in nude mice were observed at passage 30 (P30) while it occurred at P50 B-1A2 cells.
|
24114584 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Bone marrow chimeras revealed that NF-κB1 exerted tumor suppressive functions in both epithelial and hematopoietic cells.
|
29562203 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Characterization of sonic hedgehog as a novel NF-kappaB target gene that promotes NF-kappaB-mediated apoptosis resistance and tumor growth in vivo.
|
18772349 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Conclusion The levels of NF-κB p50 and NF-κB p65 in samples of thyroid carcinoma were positively associated with tumour diameter and the presence of lymph node metastasis.
|
30014762 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of NF-κB p50 in tumor stroma limits the control of tumors by radiation therapy.
|
22761754 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, we show in mouse models that the inhibition of the non-canonical NF-kB pathway restores senescence and induces a dramatic reduction in tumor growth compared with controls, thus providing potential drug targets for the re-induction of senescence in melanoma and other cancers where EZH2 is overexpressed.
|
26364600 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Flow cytometry was also used to measure DNA Index and tumor S-phase fraction, in some cases using multiparameter analysis of isolated nuclei to determine DNA content and the level of the proliferation-associated antigen, p105.
|
8529468 |
1995 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Further functional assays showed that NFKB1 was a tumour suppressor in cervical cancer by inhibiting cell proliferation, colony formation and migration, while the mutation in NFKB1 could weaken the tumour suppressing functions of NFKB1.
|
29484114 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Further, treatment with triptolide resulted in a decreased activity of Sp1 and NF-kB the two major oncogenic signaling pathway in pancreatic cancer along with a decreased tumor initiating cell (TIC) population in pancreatic tumor.
|
28801636 |
2017 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Furthermore, female HCC patients carrying the NFKB1 -94 Ins polymorphism were associated with lower clinical stages and smaller tumor sizes.
|
23457512 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Genomic and expression alterations of the alternative NF-kB pathway were examined in 279 HNSCC tumors from The Cancer Genome Atlas (TCGA) and a panel of HNSCC lines.
|
30488488 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In agreement, myeloid-specific ablation of p50 promoted tumor resistance in mice, whereas in colorectal cancer patients, a high number of p50<sup>+</sup> TAMs at the invasive margin was associated with decreased <i>IL12A</i> and <i>TBX21</i> expression and worse postsurgical outcome.
|
29588321 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast, each of the tumor cell lines displayed dramatically elevated levels of subsets of the non-canonical NFkappaB target genes CCL19, CCL21, CXCL12, CXCL13 and BAFF.
|
19502791 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In summary, the tumor suppressor mechanism at 13q14.3 is a cluster of genes controlled by two lncRNA genes that are regulated by DNA-methylation and histone modifications and whose members all regulate NF-kB.
|
23593011 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Increased DNA binding activity and differential expression of NF-κB proteins was observed with p50 and c-Rel being the two major DNA binding partners forming the functional NF-κB complex that increased as a function of severity of lesions in both HPV<sup>+/-ve</sup> tumors but selective participation of p65 in HPV16<sup>+ve</sup> TSCCs induced well differentiation of tumors resulting in better prognosis. siRNA treatment against c-Rel or Fra-2 led to upregulation of p27 but strong inhibition of c-Rel, c-Jun, c-myc, HPVE6/E7 and Fra-2 which is exclusively overexpressed in HPV<sup>-ve</sup> aggressive tumors.
|
30250646 |
2018 |