|
Liver carcinoma
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
The current study examined associations of polymorphisms within promoter regions of NFKB1 encoding NF-κB1 and NFKBIA encoding IκBα with the susceptibility of developing HCC and clinicopathological characteristics of the tumors.
|
23457512 |
2013 |
|
Ectodermal dysplasia, hypohidrotic, with immune deficiency
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
Hypomorphic mutations in the X-linked NEMO gene and hypermorphic mutations in the autosomal IKBA gene cause X-linked recessive and autosomal dominant anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) syndromes.
|
21734245 |
2011 |
|
Liver carcinoma
|
0.350 |
Therapeutic
|
disease |
CTD_human |
Hepatocyte IKK2 protects Mdr2-/- mice from chronic liver failure.
|
22022477 |
2011 |
|
Liver carcinoma
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
By multivariate regression analysis, NFKB1 -94ATTG2, NFKBIA -826T, NFKBIA -881AG and HBV genotype C were independently associated with an increased risk of HCC.
|
19797428 |
2009 |
|
Ectodermal dysplasia, hypohidrotic, with immune deficiency
|
0.350 |
GermlineCausalMutation
|
disease |
ORPHANET |
A novel mutation in NFKBIA/IKBA results in a degradation-resistant N-truncated protein and is associated with ectodermal dysplasia with immunodeficiency.
|
18412279 |
2008 |
|
Liver carcinoma
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
In this review, we focus on polymorphisms of the NFKB and NFKBI genes in relation to development of common inflammatory diseases including ulcerative colitis (UC), Crohn's disease (CD), rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, giant cell arthritis, type 1 diabetes, multiple sclerosis, celiac disease, and Parkinson's disease, as well as susceptibility of several cancers, such as oral squamous cell carcinoma, colorectal cancer (CRC), hepatocellular carcinoma, breast cancer and myeloma.
|
17701919 |
2007 |
|
Ectodermal dysplasia, hypohidrotic, with immune deficiency
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
Subjects with anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) carry either X-linked recessive hypomorphic mutations in NEMO or autosomal dominant hypermorphic mutations in IKBA.
|
15661018 |
2005 |
|
Liver carcinoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical staining to search for active nuclear RelA and nuclear IkappaBalpha proteins were done on formalin fixed liver tissues from 65 patients with HCC and from 9 normal control participants.
|
11147598 |
2000 |
|
Liver carcinoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
IkappaBalpha gene therapy in tumor necrosis factor-alpha- and chemotherapy-mediated apoptosis of hepatocellular carcinomas.
|
11059688 |
2000 |
|
Psoriasis
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
One variant in NFKBIA, rs12883343, had a significantly different association with psoriatic arthritis than with cutaneous psoriasis (p = 4.93×10-10, odds ratio 2.371).
|
30176044 |
2019 |
|
Malignant neoplasm of breast
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
To explore the association of NFKB1 c.-798_-795delATTG (rs28362491), NFKBIA c.-949C>T (rs2233406), IL-8 c.-352A>T (rs4073), IL-10 c.-854T>C (rs1800871), TNF c.-418G>A (rs361525), and TNF c.-488G>A (rs1800629) polymorphisms with breast cancer risk in an East Chinese population.
|
25559835 |
2014 |
|
Psoriasis
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
We identified the missense variant rs2303138 (p.Ala763Thr) within the LNPEP gene associated with psoriasis (Pcombined=1.83 × 10(-13), odds ratio=1.16) and validated four previously reported genes: IL28RA, NFKBIA, TRAF3IP2, and CARD14 (9.74 × 10(-11)P9.37 × 10(-5)), which confirmed the involvement of the nuclear factor-κB signaling pathway in psoriasis pathogenesis.
|
23897274 |
2014 |
|
Breast Carcinoma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
To explore the association of NFKB1 c.-798_-795delATTG (rs28362491), NFKBIA c.-949C>T (rs2233406), IL-8 c.-352A>T (rs4073), IL-10 c.-854T>C (rs1800871), TNF c.-418G>A (rs361525), and TNF c.-488G>A (rs1800629) polymorphisms with breast cancer risk in an East Chinese population.
|
25559835 |
2014 |
|
Malignant neoplasm of breast
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Functional analysis revealed that in CAFs, genes associated with proliferation (NRG1, WNT5A, PDGFC) were down regulated and those involved in immune modulation (NFKBIA, TREM-1) were up regulated, consistent with anti tumor activities of 1,25D in breast cancer.
|
22939885 |
2013 |
|
Psoriasis
|
0.330 |
Biomarker
|
disease |
BEFREE |
These results showed that two common susceptibility loci (NFKBIA and IL28RA) are shared by psoriasis and SLE in the Chinese Han population.
|
24070858 |
2013 |
|
Breast Carcinoma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Functional analysis revealed that in CAFs, genes associated with proliferation (NRG1, WNT5A, PDGFC) were down regulated and those involved in immune modulation (NFKBIA, TREM-1) were up regulated, consistent with anti tumor activities of 1,25D in breast cancer.
|
22939885 |
2013 |
|
Psoriasis
|
0.330 |
Biomarker
|
disease |
CTD_human |
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
|
20953190 |
2010 |
|
Malignant neoplasm of breast
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
In this review, we focus on polymorphisms of the NFKB and NFKBI genes in relation to development of common inflammatory diseases including ulcerative colitis (UC), Crohn's disease (CD), rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, giant cell arthritis, type 1 diabetes, multiple sclerosis, celiac disease, and Parkinson's disease, as well as susceptibility of several cancers, such as oral squamous cell carcinoma, colorectal cancer (CRC), hepatocellular carcinoma, breast cancer and myeloma.
|
17701919 |
2007 |
|
Breast Carcinoma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
In this review, we focus on polymorphisms of the NFKB and NFKBI genes in relation to development of common inflammatory diseases including ulcerative colitis (UC), Crohn's disease (CD), rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, giant cell arthritis, type 1 diabetes, multiple sclerosis, celiac disease, and Parkinson's disease, as well as susceptibility of several cancers, such as oral squamous cell carcinoma, colorectal cancer (CRC), hepatocellular carcinoma, breast cancer and myeloma.
|
17701919 |
2007 |
|
Malignant neoplasm of breast
|
0.330 |
Biomarker
|
disease |
CTD_human |
ERE-independent ERalpha target genes differentially expressed in human breast tumors.
|
16298037 |
2005 |
|
Breast Carcinoma
|
0.330 |
Biomarker
|
disease |
CTD_human |
ERE-independent ERalpha target genes differentially expressed in human breast tumors.
|
16298037 |
2005 |
|
Nasopharyngeal carcinoma
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
The identified loss-of-function mutations in NFKBIA leading to protein truncation contributed to the altered NF-κB activity, which is critical for NPC tumorigenesis.
|
27647909 |
2016 |
|
Nasopharyngeal carcinoma
|
0.320 |
SomaticCausalMutation
|
disease |
ORPHANET |
The identified loss-of-function mutations in NFKBIA leading to protein truncation contributed to the altered NF-κB activity, which is critical for NPC tumorigenesis.
|
27647909 |
2016 |
|
Nasopharyngeal carcinoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
In addition to expression of the viral oncoprotein LMP1, genetic alteration of several NF-κB regulators (eg TRAF3, TRAF2, NFKBIA, A20) also contributes to the aberrant NF-κB activation in EBV-associated NPC.
|
23868181 |
2013 |
|
Nodular Lymphocyte Predominant Hodgkin Lymphoma
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
The low mutation frequency and the absence of biallelic destructive mutations propose a minor contribution of NFKBIA and TNFAIP3 mutations to the NF-kappaB activity of NLPHL, suggesting different mechanisms of NF-kappaB activation in NLPHL and cHL.
|
19648161 |
2010 |