NGF, nerve growth factor, 4803

N. diseases: 616; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0000737
Disease: Abdominal Pain
Abdominal Pain
0.010 AlteredExpression phenotype BEFREE Pathogenesis of abdominal pain in bowel obstruction: role of mechanical stress-induced upregulation of nerve growth factor in gut smooth muscle cells. 28079757 2017
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.030 Biomarker phenotype BEFREE Early and late behavioral changes in sciatic nerve injury may be modulated by nerve growth factor and substance P in rats: a chronic constriction injury long-term evaluation. 28685530 2017
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.030 AlteredExpression phenotype BEFREE These results supported an association between the reduction of NGF levels and psychiatric disorders. 27898323 2017
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.030 AlteredExpression phenotype BEFREE Early life events, such as psychophysical stress, affect NGF and BDNF levels and induce dysregulation of the HPA axis, thereby affecting brain development and contributing to inter-individual differences in vulnerability to stress or psychiatric disorders. 20712016 2010
CUI: C0262444
Disease: Abnormality of the dentition
Abnormality of the dentition
0.100 Biomarker phenotype HPO
CUI: C4021816
Disease: Abnormality of the gingiva
Abnormality of the gingiva
0.100 Biomarker disease HPO
CUI: C0344307
Disease: Absence of pain sensation
Absence of pain sensation
0.100 Biomarker phenotype HPO
CUI: C4316903
Disease: Absence Seizures
Absence Seizures
0.300 Biomarker phenotype CTD_human Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures. 18815271 2008
CUI: C4732740
Disease: Acral ulceration
Acral ulceration
0.100 Biomarker phenotype HPO
CUI: C2215101
Disease: Acute cerebral ischemia
Acute cerebral ischemia
0.010 Biomarker disease BEFREE NGF/FAK signal pathway is implicated in angiogenesis after acute cerebral ischemia in rats. 29458087 2018
CUI: C0162565
Disease: Acute intermittent porphyria
Acute intermittent porphyria
0.010 AlteredExpression disease BEFREE NGF expression was stronger in type 1 AIP than in CP, whereas TrkA expression in type 1 AIP was poorer than in CP. 28270361 2018
CUI: C1279945
Disease: Acute interstitial pneumonia
Acute interstitial pneumonia
0.010 AlteredExpression disease BEFREE NGF expression was stronger in type 1 AIP than in CP, whereas TrkA expression in type 1 AIP was poorer than in CP. 28270361 2018
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.010 AlteredExpression disease BEFREE This was accompanied by a corresponding decrease in proteins quantities of NGF and c-fos in the CSAD group in the LSG after AMI compared to the sham group. 30877783 2019
CUI: C0184567
Disease: Acute onset pain
Acute onset pain
0.010 GeneticVariation phenotype BEFREE Rare human nerve growth factor-β mutation reveals relationship between C-afferent density and acute pain evaluation. 27146986 2016
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.010 Biomarker group BEFREE NGF and proNGF were also increased in squamous cell carcinoma, as well as in adenocarcinoma (p < 0.0001). 29802376 2018
CUI: C0281361
Disease: Adenocarcinoma of pancreas
Adenocarcinoma of pancreas
0.010 AlteredExpression disease BEFREE Serum nerve growth factor level indicates therapeutic efficacy of 125I seed implantation in advanced pancreatic adenocarcinoma. 26439032 2015
CUI: C0007112
Disease: Adenocarcinoma of prostate
Adenocarcinoma of prostate
0.010 Biomarker disease BEFREE We have investigated the effect of nerve growth factor (NGF) in the androgen-dependent, prostate adenocarcinoma LNCaP cell line. 10628752 2000
CUI: C0010606
Disease: Adenoid Cystic Carcinoma
Adenoid Cystic Carcinoma
0.010 AlteredExpression disease LHGDN Nerve growth factor and tyrosine kinase A in human salivary adenoid cystic carcinoma: expression patterns and effects on in vitro invasive behavior. 16546643 2006
CUI: C0032580
Disease: Adenomatous Polyposis Coli
Adenomatous Polyposis Coli
0.010 AlteredExpression disease BEFREE Although these data suggest the presence of ongoing neuronal stress, there was no upregulation of neurotrophins (nerve growth factor and neurotrophin-3) in FAP nerves. 11567048 2001
CUI: C4551683
Disease: Adrenal Gland Pheochromocytoma
Adrenal Gland Pheochromocytoma
0.100 AlteredExpression disease BEFREE The promoter region(s) involved in induction of interleukin 1 alpha expression by nerve growth factor in PC12 pheochromocytoma cells were studied by deletion mutagenesis in a part of the 5' regulatory region of the human interleukin 1 alpha gene (bases -163 to +64). 8939459 1996
CUI: C4551683
Disease: Adrenal Gland Pheochromocytoma
Adrenal Gland Pheochromocytoma
0.100 Biomarker disease BEFREE In this report, we describe the transfection of the nerve growth factor (NGF)-responsive pheochromocytoma cell line PC12 with the human GAP-43 cDNA under the control of the Moloney murine leukemia virus long terminal repeat (MoMuLV LTR). 2153893 1990
CUI: C4551683
Disease: Adrenal Gland Pheochromocytoma
Adrenal Gland Pheochromocytoma
0.100 Biomarker disease BEFREE NID67, a small putative membrane protein, is preferentially induced by NGF in PC12 pheochromocytoma cells. 11288140 2001
CUI: C4551683
Disease: Adrenal Gland Pheochromocytoma
Adrenal Gland Pheochromocytoma
0.100 Biomarker disease BEFREE K-252a has been reported to specifically inhibit the effects of NGF on PC12 pheochromocytoma cells. 1702431 1991
CUI: C4551683
Disease: Adrenal Gland Pheochromocytoma
Adrenal Gland Pheochromocytoma
0.100 Biomarker disease BEFREE Human neuroblastoma SH-SY5Y and IMR32 cells and rat phaeochromocytoma PC12 cells were used as an in vitro system for neuronal differentiation and were induced to differentiate in the presence of retinoic acid, a combination of dibutyryl cAMP and 5-bromodeoxyuridine, and nerve growth factor respectively. 8963445 1996
CUI: C4551683
Disease: Adrenal Gland Pheochromocytoma
Adrenal Gland Pheochromocytoma
0.100 Biomarker disease BEFREE Moreover, NGF could be chemically cross-linked to the endogenous gp140trk present in rat PC12 pheochromocytoma cells as well as to gp140trk ectopically expressed in mouse fibroblasts and in insect Sf9 cells. 1849459 1991