|
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Increasing the expression of GTP cyclohydrolase 1, the rate-limiting enzyme in the de novo biosynthesis of tetrahydrobiopterin, exercise training couples endothelial nitric oxide synthase, reduces oxidative stress, and increases nitric oxide bioavailability and sensitivity in coronary arteries of heart failure rats.
|
29351461 |
2018 |
|
Congestive heart failure
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Thus, increased VCAM-1 and PAI-1, and decreased eNOS phosphorylation through the TLR4/NFκB/p38 pathway, may be associated with atrial thrombogenesis in the heart failure mice model.
|
23754516 |
2014 |
|
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This prospective study was designed to analyze the impact of three eNOS polymorphisms (T-786C, VNTR4a/b and Glu298Asp) and their haplotypes on the susceptibility and clinical outcomes in HF outpatients with systolic dysfunction.
|
22290017 |
2012 |
|
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
After myocardial infarction, up-regulation of myocardial nNOS attenuates adverse remodeling and prevents arrhythmias whereas uncoupled eNOS activity in murine models of left ventricular pressure overload accelerates the progress towards heart failure.
|
21945464 |
2012 |
|
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Homozygosity for the G allele of the eNOS G894T polymorphism was associated with worse survival in systolic HF patients, especially in those treated with nitrates.
|
25917853 |
2015 |
|
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thus, targeted overexpression of the eNOS gene within the vascular endothelium in mice attenuates both cardiac and pulmonary dysfunction and dramatically improves survival during severe congestive heart failure.
|
12676984 |
2003 |
|
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The mRNA expressions of Cav1.2, Nav1.5, Kir2.1, KvLQT1, phosphoinositide 3-kinase, AKT, and endothelial nitric oxide synthase in HF-RDN were significantly higher compared with HF.
|
29358197 |
2018 |
|
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In coronary arteries from HF animals, SERCA2a and endothelial isoform of nitric oxide synthase (eNOS) protein expression were decreased, but restored to normal levels by SERCA2a gene transfer.
|
20461063 |
2010 |
|
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
NOS3 -786 C/T rs2070744 polymorphism in DCM may serve as a marker for more rapid progression of heart failure.
|
27448535 |
2016 |
|
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
After controlling for demographics, functional status, and treatment adherence, polymorphisms in ADRB1, ADRB2 and eNOS are associated with healthcare outcomes in heart failure patients.
|
22543981 |
2012 |
|
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to examine the association between polymorphisms of ACE and eNOS gene complexes and AF in an unselected series of patients with congestive heart failure (CHF).
|
16818212 |
2006 |
|
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
For NOS3 -922 A>G (rs1800779), a higher HR was found in minor allele carriers for heart failure (AA = 1.00, AG+GG = 1.10 (CI = 1.00-1.21), P = 0.046).
|
22470539 |
2012 |
|
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Endothelial nitric oxide synthase (NOS3) polymorphisms in African Americans with heart failure: results from the A-HeFT trial.
|
19327620 |
2009 |
|
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Expression of constitutive NOS isoforms in heart exhibits wide variability in HF patients, but this variability was not related to aetiology, disease severity, concomitant pathologies or drug regimes.
|
23770231 |
2013 |
|
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Heart failure and endothelial nitric oxide synthase G894T gene polymorphism frequency variations within ancestries.
|
28554876 |
2018 |
|
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our findings suggest the possible implication of NOS3 gene in the disease phenotype, wherein NOS3 may be synergistically functioning in DCM associated heart failure via the excessive production of NO in cardiomyocytes resulting in decreased myocardial contractility and systolic dysfunction, a common feature of DCM phenotype.
|
23923002 |
2013 |
|
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The results of the present study suggest that Ato upregulates eNOS by inhibiting RhoA/Rho kinase overexpression in the myocardial tissue of rats with CHF, thus improving left ventricular remodeling and cardiac function.
|
30651887 |
2019 |
|
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Endothelial nitric oxide synthase Glu298Asp gene polymorphism in a multi-ethnical population with heart failure and controls.
|
20079452 |
2010 |
|
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We conclude that heart failure down-regulates both eNOS activity and expression in cardiac tissue from patients with LVEF <35%.
|
15334196 |
2004 |
|
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Despite the fact that women were older than men (72.3 vs. 69.5 years, p = 0.001) at recruitment, poor long-term survival was not sex-related, but instead predicted by age (p < 0.0001), cardiac failure (p = 0.004), smoking (p = 0.017), diabetes (p = 0.049), and variation in the eNOS gene locus (p = 0.033).
|
18648197 |
2008 |
|
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Endothelial nitric oxide synthase (eNOS) Glu298Asp single nucleotide polymorphism (SNP) genotype has been associated with a worse phenotype amongst patients with established heart failure and in patients with progression of their renal disease.
|
25612295 |
2015 |
|
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Effect of the Asp298 variant of endothelial nitric oxide synthase on survival for patients with congestive heart failure.
|
12668492 |
2003 |
|
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated the NOS3-786T>C polymorphism in chronic heart failure (CHF) and its effects on long-term mortality.
|
29033513 |
2017 |
|
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Patients with congestive heart failure who are homozygous for this polymorphism of the eNOS promoter were found to have a more advanced autonomic imbalance.
|
15846275 |
2005 |
|
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have analyzed the role of the genetic polymorphism of endothelial nitric oxide synthase on heart failure prognosis.
|
23949326 |
2013 |