NOS3, nitric oxide synthase 3, 4846

N. diseases: 706; N. variants: 39
Disease: Diabetic Nephropathy ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 GeneticVariation disease BEFREE To investigate the association of functional single nucleotide polymorphisms (SNPs) of the endothelial nitric oxide synthase gene (eNOS) gene (T-786C, G894T) and one variable number tandem repeat polymorphism (aa 27VNTR bb) with reno-protective response to angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) therapy in North Indian type 2 diabetic mellitus (T2DM) subjects with cases having diabetic nephropathy (DN) and controls without DN. 23260854 2013
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 GeneticVariation disease BEFREE Overall, although there is some evidence of association between NOS type III 4b/a polymorphism and DN in Asian population, the more reliable findings need further and more rigorous, prospective and high-quality studies. 25296103 2014
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 GeneticVariation disease LHGDN We evaluated the association of the constitutive endothelial nitric oxide synthase gene (eNOS) polymorphisms with type 2 diabetic nephropathy. 18401556 2008
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 GeneticVariation disease BEFREE The aim of this study was to evaluate the association of three polymorphisms of the eNOS gene (894G>T, -786T>C, and 27-bp-VNTR) with the risk of DN among type 2 diabetic patients. 22313046 2012
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 GeneticVariation disease BEFREE These results imply that the ecNOS gene polymorphism may be associated with progression to diabetic nephropathy in Japanese type 2 diabetic patients. 10868974 2000
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 GeneticVariation disease BEFREE We therefore studied association between DN and two polymorphisms in NOS3, Glu298Asp and NOS4ab, in Caucasian type 1 diabetes (T1D) patients. 17101543 2006
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 GeneticVariation disease BEFREE Endothelial nitric oxide synthase gene (eNOS-3) polymorphisms have been associated with DN, however some studies do not confirm this association. 24433471 2014
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 GeneticVariation disease BEFREE Studies exploring gene and environment interactions with endothelial nitric oxide synthase polymorphisms may help understand better the genetics of diabetic nephropathy. 19773668 2009
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 GeneticVariation disease BEFREE For eNOS-G894T, there was an association between T allele and DN risk in the global, Asian and African population in DN/T2DM group. 26489520 2015
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 GeneticVariation disease BEFREE We conclude that there is no association of the ecNOS gene polymorphism with the development of diabetic nephropathy in Japanese patients with type 2 diabetes. 12413777 2002
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 GeneticVariation disease BEFREE The evidence accumulated suggested that 4b/a and G894T polymorphisms in the eNOS gene were associated with susceptibility to DN in Asian populations, but not in Caucasian populations. 21084433 2011
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 GeneticVariation disease BEFREE We evaluated the association of the constitutive endothelial nitric oxide synthase gene (eNOS) polymorphisms with type 2 diabetic nephropathy. 18401556 2008
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 GeneticVariation disease BEFREE Lack of association between an ecNOS gene polymorphism and diabetic nephropathy in type 2 diabetic patients with proliferative diabetic retinopathy. 10741691 2000
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 GeneticVariation disease BEFREE We evaluated the association of -786T>C (promoter region), Glu298Asp (Exon 7), and 4b4a (Intron 4) polymorphisms in eNOS gene with Type 2 diabetes mellitus (T2DM) and DN by haplotype analysis. 18413207 2008
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 GeneticVariation disease BEFREE However, larger future prospective studies are required to confirm the role of eNOS gene polymorphism in the progression of diabetic nephropathy to ESRD. 21854353 2011
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 GeneticVariation disease LHGDN We conclude that there is no association of the ecNOS gene polymorphism with the development of diabetic nephropathy in Japanese patients with type 2 diabetes. 12413777 2002
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 GeneticVariation disease BEFREE However, a link between eNOS Glu298Asp gene polymorphism and DN risk was not found in overall populations, Asians, Caucasians, and Brazil population. 23113598 2013
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 GeneticVariation disease BEFREE This study aimed to elucidate the roles of eNOS and the angiotensin-converting enzyme (ACE) gene polymorphism for the progression of type 2 diabetic nephropathy (DN). 15331206 2004
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 GeneticVariation disease BEFREE At last, a positive correlation of family history of diabetes with NOS3 rs11771443 polymorphism was found in DN. 27192959 2016
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 GeneticVariation disease BEFREE Logistic regression analysis identified SNPs AGER 2184A/G and NOS3 774C/T, together with diabetes duration and HbA1c, as significant predictors of DN. 17345061 2007
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 Biomarker disease BEFREE The results revealed that variations of ACE and eNOS gene had association with DN, which indicated ACE and eNOS gene may play an important role in pathogenesis of DN in Northern Chinese Han population. 25227524 2015
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 Biomarker disease CTD_human eNOS knockout mice with advanced diabetic nephropathy have less benefit from renin-angiotensin blockade than from aldosterone receptor antagonists. 20042665 2010
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 Biomarker disease BEFREE Endothelial nitric oxide synthase (eNOS) deficiency may contribute to the pathogenesis of diabetic nephropathy in both experimental models and humans, but the underlying mechanism is not fully understood. 22997257 2012
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 Biomarker disease BEFREE Based on these results NOS3 can be considered a modifier gene for DN. 24603156 2013
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.600 Biomarker disease BEFREE Role of endothelial nitric oxide synthase in diabetic nephropathy: lessons from diabetic eNOS knockout mice. 25371905 2014