Anorexia
|
0.570 |
AlteredExpression
|
disease |
BEFREE |
We selected three human cancer cell lines [human melanoma (SEKI), human melanoma (G361), and human neuroepithelioma (NAGAI)] that have an ability to develop cancer cachexia syndrome with and without accompanying anorexia and examined the hypothalamic levels of mRNAs for neuropeptide Y (NPY), melanin-concentrating hormone, and orexin.
|
12094613 |
2001 |
Anorexia
|
0.570 |
Biomarker
|
disease |
BEFREE |
The orexigenic neuropeptides are neuropeptide Y (NPY) and agouti-related peptide (AgRP) and the anorexic neuropeptides are alpha-melanocyte-stimulating hormone (alpha-MSH) and cocaine and amphetamine-related transcript (CART).
|
12468411 |
2002 |
Anorexia
|
0.570 |
Biomarker
|
disease |
BEFREE |
Additionally, neuropeptide Y-induced feeding appears to be inhibited in this tumor anorexia model, and this may correlate with increased expression of corticotropin-releasing hormone.
|
15567470 |
2004 |
Anorexia
|
0.570 |
Biomarker
|
disease |
CTD_human |
To determine if c-fos or c-jun was involved in the anorectic response of AMPH, infusions of antisense oligonucleotide into the brain were performed at 1 h before daily AMPH treatment in freely moving rats, and the results showed that c-fos or c-jun knockdown could block this anorectic response and restore NPY mRNA level.
|
16084549 |
2006 |
Anorexia
|
0.570 |
Biomarker
|
disease |
CTD_human |
To determine if PKCalpha was involved in the anorectic response of AMPH, the infusions of antisense oligonucleotide into the brain were performed 1 h before daily AMPH treatment in freely moving rats, and the results showed that PKCalpha knock down could block the anorectic response and restore NPY mRNA levels in AMPH-treated rats.
|
16101753 |
2005 |
Anorexia
|
0.570 |
Biomarker
|
disease |
RGD |
Based on two replicates of four pooled samples each, both NPY and AgRP mRNA appeared to be elevated in the VMA of anorectic TB rats, while only AgRP exhibited a similar increase in the DMA.
|
17234300 |
2007 |
Anorexia
|
0.570 |
Biomarker
|
disease |
BEFREE |
The neuropeptide Y system has proven to be one of the most important regulators of feeding behaviour and energy homeostasis, thus presenting great potential as a therapeutic target for the treatment of disorders such as obesity and at the other extreme, anorexia.
|
21545413 |
2011 |
Anorexia
|
0.570 |
AlteredExpression
|
disease |
BEFREE |
Leptin treatment decreases Arc ceramide levels, with the decrease being important in leptin-induced anorectic actions and down-regulations of NPY and Bsx.
|
21593415 |
2011 |
Anorexia
|
0.570 |
Biomarker
|
disease |
CTD_human |
Involvement of oxidative stress in the regulation of NPY/CART-mediated appetite control in amphetamine-treated rats.
|
25825358 |
2015 |
Anorexia
|
0.570 |
Biomarker
|
disease |
BEFREE |
Although acute loss of hypothalamic neurons that produce appetite-stimulating neuropeptide Y (Npy) and agouti-related peptide (Agrp) in adult mice or in mice homozygous for the anorexia (<i>anx</i>) mutation causes aphagia, our understanding of the factors that help maintain appetite regulatory circuitry is limited.
|
28093506 |
2017 |
Anorexia
|
0.570 |
AlteredExpression
|
disease |
BEFREE |
EA treatment at CV12 reduced the levels of plasma monoamine neurotransmitters 5-hydroxytryptamine, 5-hydroxyindoleacetic acid, dopamine, and norepinephrine; as well as stimulated the expression of GHRL and NPY to alleviate cisplatin-induced anorexia in rats.
|
31635295 |
2019 |