NPY, neuropeptide Y, 4852

N. diseases: 381; N. variants: 12
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 GeneticVariation disease BEFREE More studies on different ethnic groups are needed to further elucidate the influence of the NPY gene on alcoholism. 12454738 2002
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 GeneticVariation disease BEFREE The aim of this study was to examine whether polymorphic variants of the NPY gene are associated with the diagnosis of alcohol dependence. 15897713 2005
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 GeneticVariation disease BEFREE In conclusion, our results suggest that the analyzed SNPs, as well as the corresponding haplotypes of the NPY gene are unlikely to play a major role in the pathophysiology of alcohol dependence in the investigated sample from the German population. 18241322 2008
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 GeneticVariation disease BEFREE Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. 18828811 2008
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 GeneticVariation disease BEFREE NPY Leu7Pro and alcohol dependence in Finnish and Swedish populations. 12544000 2003
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 GeneticVariation disease BEFREE No leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y in Japanese population or Japanese with alcoholism. 11409703 2001
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 GeneticVariation disease BEFREE Association of the NPY gene with alcohol dependence was tested by using logistic regression and haplotype analyses and linkage disequilibrium. 23652361 2013
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 GeneticVariation disease BEFREE Genetic studies on alcoholism examining the metabolism of alcohol and the dopaminergic, GABAergic, glutamatergic, opioid, cholinergic and serotonergic neurotransmitter systems as well as the neuropeptide Y are presented. 17669369 2008
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 GeneticVariation disease BEFREE These results suggest that the NPY Pro7 allele is a risk factor for alcohol dependence. 12215082 2002
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 GeneticVariation disease BEFREE We speculate that the genetic polymorphism producing the proline(7) substitution of NPY might not predispose to alcoholism, but indeed retard the transition to alcoholism. 11696660 2001
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.600 GeneticVariation disease BEFREE Study of the downstream effectors of CREB have identified several important CREB-related genes, such as neuropeptide Y, brain-derived neurotrophic factor, activity-regulated cytoskeleton-associated protein, and corticotrophin-releasing factor, that may play a crucial role in the behavioral effects of ethanol and molecular changes in the specific neurocircuitry that underlie both alcohol addiction and a genetic predisposition to alcoholism. 19756388 2010
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.600 GeneticVariation disease BEFREE Since APOE varepsilon4 allele is also a major risk factor for the development of Alzheimer's disease (AD) and the genetic polymorphism of NPY has not previously been studied in dementing disorders, we have examined whether a novel polymorphism in a signal peptide of NPY gene is associated with AD alone or in combination with APOE varepsilon4. 10841982 2000
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.600 GeneticVariation disease BEFREE Our data support the observation, that NPY polymorphisms might influence cholesterol metabolism, but might not act as major risk factor in AD. 15959845 2006
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 GeneticVariation disease BEFREE Statistical analysis showed a significant correlation between the SNP sites rs16139 in NPY and the morbidity of depression. 23468908 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 GeneticVariation disease BEFREE No significant differences in NPY IgG autoAb affinities between patients with depression and controls were found, but higher affinity of IgG autoAbs for NPY was associated with lower body mass index and prevented NPY-induced orexigenic response in mice after their central injection. 22365482 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 GeneticVariation disease BEFREE Five NPY gene variants were investigated for an influence on antidepressant treatment response in a sample of 256 patients with depression. 19854625 2010
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 GeneticVariation disease BEFREE Pro7 allele of preproNPY protected against depression among Swedes. 19264362 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 GeneticVariation disease BEFREE Pro7 allele of preproNPY protected against depression among Swedes. 19264362 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 GeneticVariation disease BEFREE Five NPY gene variants were investigated for an influence on antidepressant treatment response in a sample of 256 patients with depression. 19854625 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 GeneticVariation disease BEFREE Statistical analysis showed a significant correlation between the SNP sites rs16139 in NPY and the morbidity of depression. 23468908 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.560 GeneticVariation disease BEFREE A neuropeptide Y variant (rs16139) associated with major depressive disorder in replicate samples from Chinese Han population. 23468908 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.560 GeneticVariation disease BEFREE A polymorphism in the promoter region of the NPY gene at position -399 C > T was recently reported to be associated with schizophrenia in a Japanese population and with treatment refractory unipolar depression in a Swedish population. 16390370 2006
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.560 GeneticVariation disease BEFREE To test this hypothesis, we compared plasma levels and affinities of NPY-reactive autoAbs between patients with major depression and healthy controls. 22365482 2012
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.510 GeneticVariation disease BEFREE Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. 18828811 2008
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.400 GeneticVariation group BEFREE In conclusion, we provide further support for involvement of mainly GAD1, but also NPY in determining predisposition to anxiety disorders. 22328461 2012