|
Eclampsia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MicroRNA-16 is involved in the pathogenesis of pre-eclampsia via regulation of Notch2.
|
31643078 |
2020 |
|
Adenoma
|
0.010 |
Biomarker
|
group |
BEFREE |
We found that the Notch2/Delta-like Notch ligand 3 (DLL3) signaling pathway was active in GHoma tumorigenesis, progression, and invasion.The γ-secretase inhibitor DAPT is of potential use in GHoma treatment targeting Notch signaling.
|
31508369 |
2019 |
|
Merkel cell carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Therefore, association of NOTCH1/ NOTCH2/NOTCH3/jagged 1 (JAG1) expression with MCPyV status and prognosis in MCC was investigated.
|
30591475 |
2019 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
MiR-431 is a prognostic marker and suppresses cell growth, migration and invasion by targeting NOTCH2 in melanoma.
|
31115015 |
2019 |
|
Premature Menopause
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Functional evidence implicating NOTCH2 missense mutations in primary ovarian insufficiency etiology.
|
30304577 |
2019 |
|
Ovarian Failure, Premature
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The results have demonstrated for the first time that NOTCH2 mutations contribute to POI etiology.
|
30304577 |
2019 |
|
Intervertebral Disc Degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
The current and previous results shed light on the therapeutic implications of targeting the JAG2/Notch2 axis to inhibit or reverse IVDD.
|
31619270 |
2019 |
|
Squamous cell carcinoma of skin
|
0.010 |
Biomarker
|
disease |
BEFREE |
A complex network of genes (TP53, CDKN2A, NOTCH1 and NOTCH2, EGFR and TERT) and molecular pathways (RAS/RAF/MEK/ERK and PI3K/AKT/mTOR) have been shown to play an important role in the pathogenesis of cSCC.
|
31747091 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
NOTCH2 expression in the NPC tissues of patients with cervical lymph node metastasis was lower than that of patients without cervical lymph node metastasis.
|
31699119 |
2019 |
|
CADASIL Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
NOTCH2 mutations lead to the development of Alagille syndrome, while mutations in NOTCH3 cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
|
29767458 |
2019 |
|
Nasopharyngeal carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Suppression of NOTCH2 expression promoted NPC cell metastasis, whereas NOTCH2 overexpression inhibited this process.
|
31699119 |
2019 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
We used Western blot analysis, immunofluorescence, immunohistochemical analysis, phalloidin staining, mouse tumor metastatic dissemination models, gene set enrichment analysis, immunoprecipitation assays and a series of functional assays to determine the potential role of NOTCH2 in regulating NPC metastasis.
|
31699119 |
2019 |
|
Lymphoepithelioma-Like Hepatocellular Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, SNV incidences of specific genes (CTNNB1, AXIN1, NOTCH1, and NOTCH2) were significantly higher in c-HCC than LEL-HCC, suggesting a plausible link between activated Wnt/β-catenin and Notch signaling pathways and immune avoidance.
|
31168847 |
2019 |
|
Malignant neoplasm of endometrium
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the prognostic value of the Hedgehog (Gli, Patched-1, Shh, Smo) and Notch (Jag1, Notch2, Notch3) pathway members, in comparison to a panel of proteins (ER, PgR, HER2/neu, Ki67, p53, p16, PTEN and MMR) previously suggested to be involved in the pathogenesis of endometrial cancer, in association with clinical outcome and standard clinicopathological characteristics.
|
30521558 |
2018 |
|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
Integrated Analysis Reveals Altered Lipid and Glucose Metabolism and Identifies NOTCH2 as a Biomarker for Parkinson's Disease Related Depression.
|
30233306 |
2018 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Integrated Analysis Reveals Altered Lipid and Glucose Metabolism and Identifies NOTCH2 as a Biomarker for Parkinson's Disease Related Depression.
|
30233306 |
2018 |
|
Diabetic Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Altered expression of WFS1 and NOTCH2 genes may play a role in pathogenesis and development of DN in patients with T2DM.
|
29626590 |
2018 |
|
Diabetic Retinopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that Notch signaling in ASC underlies regulation and stabilization of dysfunctional retinal microvascular networks such as in DR. ASC prominently and constitutively expressed NOTCH2.
|
29067740 |
2018 |
|
Hand, Foot and Mouth Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Notch1 and Notch2 mRNA was also remarkably increased in CD14<sup>+</sup> monocytes from severe HFMD.
|
29702280 |
2018 |
|
Hemangiosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to evaluate the immunohistochemical expression of ATRX, DAXX and NOTCH receptors (NOTCH1 and NOTCH2) in a large cohort of angiosarcomas, and study their clinicopathological and prognostic significance.
|
28796347 |
2018 |
|
Kidney Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Transcript analysis of mouse kidney disease models, including folic-acid (FA)-induced nephropathy, unilateral ureteral obstruction (UUO), or apolipoprotein L1 (APOL1)-associated kidney disease, indicated that Jag1 and Notch2 levels were higher in all analyzed kidney fibrosis models.
|
30226866 |
2018 |
|
Liver neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Mechanistically, Notch2 expression was found to be down-regulated by the Hippo pathway in liver tumors.
|
29378174 |
2018 |
|
Chronic Obstructive Airway Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Compared with control groups, we found that the expression of Notch1, 3, and 4 decreased, as well as their target genes Hes1 and Hes2, while the expression of Notch2 and extracellular signal-regulated kinase (ERK)1/2 increased in COPD patients compared with controls, as well as in human pulmonary microvascular endothelial cells (HPMECs) when exposed to CS extract (CSE).
|
29874112 |
2018 |
|
Multiple Sclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Reduced monocyte NOTCH2 expression in nADA+ MS patients was associated with NOTCH2 activation measured by increased expression of Notch-responsive genes, polarization of monocytes toward a nonclassical phenotype, and increased proinflammatory IL-6 production.
|
29875313 |
2018 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
NOTCH1 and NOTCH2 receptors and the JAGGED1 ligand regulate chondrocyte biology; however, the contribution of Notch signaling to osteoarthritis is controversial.
|
29940267 |
2018 |