NPY2R, neuropeptide Y receptor Y2, 4887

N. diseases: 68; N. variants: 12
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.010 Biomarker disease BEFREE Normal breast tissue mainly expresses the neuropeptide Y (NPY) Y2 receptor whereas primary human breast carcinomas express the Y1 receptor (Y1R) subtype. 16585197 2006
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.310 Biomarker group PSYGENET These data provide further evidence that modulators of the NPY Y2 receptor subtype are drug targets for the treatment of anxiety and mood disorders in human subjects. 16691011 2006
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.310 Biomarker group BEFREE These data provide further evidence that modulators of the NPY Y2 receptor subtype are drug targets for the treatment of anxiety and mood disorders in human subjects. 16691011 2006
CUI: C0003467
Disease: Anxiety
Anxiety 		0.020 Biomarker disease BEFREE These data provide further evidence that modulators of the NPY Y2 receptor subtype are drug targets for the treatment of anxiety and mood disorders in human subjects. 16691011 2006
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.010 Biomarker group BEFREE These data provide further evidence that modulators of the NPY Y2 receptor subtype are drug targets for the treatment of anxiety and mood disorders in human subjects. 16691011 2006
CUI: C0028754
Disease: Obesity
Obesity 		0.300 Biomarker disease BEFREE Mutations in the human PYY and Y2 receptor genes may contribute to the development of obesity. 16756746 2006
CUI: C0028754
Disease: Obesity
Obesity 		0.300 GeneticVariation disease BEFREE Common variants rs12649641, rs2342676 and rs6857530 in the 5' region of NPY2R are associated with obesity in Danish white subjects. 17019604 2006
CUI: C0028754
Disease: Obesity
Obesity 		0.300 GeneticVariation disease BEFREE Significant association was found for a 5' variant (rs6857715) in the NPY2R gene with both severe adult obesity (p=0.002) and childhood obesity (p=0.02). 17235527 2007
CUI: C0028756
Disease: Obesity, Morbid
Obesity, Morbid 		0.020 GeneticVariation disease BEFREE Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. 17235527 2007
CUI: C2362324
Disease: Pediatric Obesity
Pediatric Obesity 		0.010 GeneticVariation disease BEFREE Significant association was found for a 5' variant (rs6857715) in the NPY2R gene with both severe adult obesity (p=0.002) and childhood obesity (p=0.02). 17235527 2007
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.010 Biomarker disease BEFREE Variation in this pathway likely does not have a major influence on BMI, although small effects cannot be ruled out; NPY2R should be considered a candidate gene for type 2 diabetes in men. 17325259 2007
CUI: C0014553
Disease: Absence Epilepsy
Absence Epilepsy 		0.200 Therapeutic disease RGD Neuropeptide Y suppresses absence seizures in a genetic rat model primarily through effects on Y receptors. 17331209 2007
CUI: C0028754
Disease: Obesity
Obesity 		0.300 Biomarker disease RGD Difference of NPY and its receptor gene expressions between obesity and obesity-resistant rats in response to high-fat diet. 17447163 2007
CUI: C0028754
Disease: Obesity
Obesity 		0.300 GeneticVariation disease BEFREE We investigated if genetic variation in the NPY2R gene is associated with obesity in German extremely obese children and adolescents. 17992642 2007
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker disease RGD Expression of neuropeptide Y and its receptors Y1 and Y2 in the rat heart and its supplying autonomic and spinal sensory ganglia in experimentally induced diabetes. 18201831 2008
CUI: C0028754
Disease: Obesity
Obesity 		0.300 GeneticVariation disease BEFREE To verify whether peptide YY (PYY) and its Y2 receptor (Y2R) gene variants can be associated with obesity or hypertension or both in a cohort of obese children and adolescents. 18622237 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.010 GeneticVariation group BEFREE Y2 receptor gene variants reduce the risk of hypertension in obese children and adolescents. 18622237 2008
CUI: C0025286
Disease: Meningioma
Meningioma 		0.010 AlteredExpression disease BEFREE Medulloblastomas, primitive neuroectodermal tumors of the CNS, and meningiomas expressed Y1 and Y2 receptor subtypes in moderate incidence and density. 18648328 2008
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.530 Biomarker disease PSYGENET SNPs in NPY2R provided significant evidence of association with alcohol dependence, alcohol withdrawal symptoms, comorbid alcohol and cocaine dependence, and cocaine dependence (all p < 0.03). 18828811 2008
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.530 Biomarker disease CTD_human SNPs in NPY2R provided significant evidence of association with alcohol dependence, alcohol withdrawal symptoms, comorbid alcohol and cocaine dependence, and cocaine dependence (all p < 0.03). 18828811 2008
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.530 GeneticVariation disease BEFREE SNPs in NPY2R provided significant evidence of association with alcohol dependence, alcohol withdrawal symptoms, comorbid alcohol and cocaine dependence, and cocaine dependence (all p < 0.03). 18828811 2008
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.310 GeneticVariation disease BEFREE SNPs in NPY2R provided significant evidence of association with alcohol dependence, alcohol withdrawal symptoms, comorbid alcohol and cocaine dependence, and cocaine dependence (all p < 0.03). 18828811 2008
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence 		0.310 Biomarker disease CTD_human SNPs in NPY2R provided significant evidence of association with alcohol dependence, alcohol withdrawal symptoms, comorbid alcohol and cocaine dependence, and cocaine dependence (all p < 0.03). 18828811 2008
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder 		0.300 Biomarker disease CTD_human Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. 18828811 2008
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.300 Biomarker disease CTD_human Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. 18828811 2008