|
Abdominal Pain
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Acoustic Neuroma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression of neurotrophic factors, such as artemin, glial cell line-derived neurotrophic factor (GDNF), neurturin, transforming growth factors (TGF)-beta1/beta2 and brain-derived neurotrophic factor (BDNF), is enhanced in vestibular schwannomas compared to peripheral nerves.
|
19937367 |
2010 |
|
Adducted thumb
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Adrenal Gland Pheochromocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression analysis of RET and the GDNF/GFRalpha-1 and NTN/GFRalpha-2 ligand complexes in pheochromocytomas and paragangliomas.
|
10998441 |
2000 |
|
Aganglionosis, Colonic
|
0.020 |
Biomarker
|
disease |
BEFREE |
Mutational analysis of RET/GDNF/NTN genes in children with total colonic aganglionosis with small bowel involvement.
|
10946353 |
2000 |
|
Aganglionosis, Colonic
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Relationship between the type of RET/GDNF/NTN or SOX10 gene mutations and long-term results after surgery for total colonic aganglionosis with small bowel involvement.
|
11685702 |
2001 |
|
aggressive cancer
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The neurotrophic factor neurturin contributes toward an aggressive cancer cell phenotype, neuropathic pain and neuronal plasticity in pancreatic cancer.
|
24067900 |
2014 |
|
Bone pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In this study, we explored roles for GDNF, neurturin, and artemin signaling in bone pain using male Sprague Dawley rats.
|
29712778 |
2018 |
|
Constipation
|
0.110 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Constipation
|
0.110 |
GeneticVariation
|
phenotype |
BEFREE |
Idiopathic slow transit constipation and megacolon are not associated with neurturin mutations.
|
12358679 |
2002 |
|
Depressed mood
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Visual analog scale pain scores significantly correlated with younger age, higher depression scores, increased expression of neurturin and decreased expression of transient receptor potential ankyrin 1 in the mucosa.
|
25358061 |
2014 |
|
Depressive disorder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Visual analog scale pain scores significantly correlated with younger age, higher depression scores, increased expression of neurturin and decreased expression of transient receptor potential ankyrin 1 in the mucosa.
|
25358061 |
2014 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Human neurturin (NTN) is a cystine knot growth factor with potential therapeutic use in diseases such as Parkinson's and diabetes.
|
28369693 |
2017 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Human neurturin (NTN) is a cystine knot growth factor with potential therapeutic use in diseases such as Parkinson's and diabetes.
|
28369693 |
2017 |
|
Diarrhea
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Dwarfism
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Encephalitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The objective was to analyze neurotrophic and oxidative parameters that could be related to midbrain dopamine neuronal loss or brain inflammation in the CSF of elderly subjects: 1) levels of the dopaminotrophic factors BDNF, GDNF, persephin, and neurturin, 2) levels of the proinflammatory factors TGFβ<sub>1</sub> and TGFβ<sub>2</sub>; 3) activity of main antioxidant enzymes (catalases, glutathione-peroxidase, glutathione-reductase, glutathione-S-transferases, peroxirredoxins, and superoxide-dismutases), 4) ferritin content, antioxidant protein which reduces reactive free iron, and 5) antioxidant potential of the cerebrospinal fluid.ELISA and PAO tests were used.
|
29775745 |
2018 |
|
Failure to thrive in infancy
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Hirschsprung Disease
|
0.150 |
Biomarker
|
disease |
BEFREE |
In summary, we report for the first time the association of PSPN gene with HSCR and confirm the involvement of NRTN in the disease, with the identification of novel variants in those genes.
|
21206993 |
2011 |
|
Hirschsprung Disease
|
0.150 |
Biomarker
|
disease |
HPO |
|
|
|
|
Hirschsprung Disease
|
0.150 |
Biomarker
|
disease |
BEFREE |
Recently, germline mutations of RET, GDNF, and NTN genes have been reported in HSCR.
|
10946353 |
2000 |
|
Hirschsprung Disease
|
0.150 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, it appears that the NTN mutation reported here is not sufficient to cause HSCR, and this multiplex family also segregates a RET mutation.
|
9700200 |
1998 |
|
Hirschsprung Disease
|
0.150 |
Biomarker
|
disease |
BEFREE |
Germline mutations of the RET proto-oncogene (RET), its ligand glial cell-derived neurotrophic factor (GDNF), and neurturin (NTN) gene have been reported in patients with Hirschsprung's disease.
|
11316186 |
2001 |
|
Hirschsprung Disease
|
0.150 |
Biomarker
|
disease |
BEFREE |
Although mutations in eight different genes (EDNRB, EDN3, ECE1, SOX10, RET, GDNF, NTN, SIP1) have been identified in affected individuals, it is now clear that RET and EDNRB are the primary genes implicated in the etiology of HSCR.
|
16618617 |
2006 |
|
Hyperglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interestingly, coadministration of NRTN and liraglutide normalized hyperglycemia and other metabolic parameters, demonstrating that combining therapies with distinct mechanism(s) can alleviate advanced diabetes.
|
28408435 |
2017 |