|
Degenerative polyarthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
There was a significant positive correlation between mRNA expression of NTRK2 (TrkB) and the proinflammatory chemokine fractalkine in the OA synovia.
|
31479064 |
2020 |
|
Cerebral dysfunction
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, it is not known whether TrkB's agonist N-acetyl serotonin (NAS) involves in neuronal damage and brain dysfunction caused by TBI that is known as one of the most important causes of disability and death worldwide.
|
31760035 |
2020 |
|
Amnesia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ribosylation-derived AGEs downregulated the BDNF-TrkB pathway in rat brains and N2a cells, leading to GSK-3β activation-mediated tau hyperphosphorylation, which was involved in the observed rat memory loss.
|
31381511 |
2019 |
|
Squamous cell carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The mRNA for TrkB-T1 is the most abundant NTRK2 gene mRNA in all squamous cell carcinomas (SCCs) in the TCGA database.
|
31221127 |
2019 |
|
Heart Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The present study enhanced current understanding of TrkB receptor in the cardiovascular system and provided a novel target for prevention and treatment of heart diseases.
|
30472367 |
2019 |
|
Leukoplakia, Oral
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Oral squamous cell carcinoma presented increased expression of BDNF/TrkB/Akt pathway compared to NOM and OL.
|
31498938 |
2019 |
|
Myocardial Ischemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) pathway is associated with ischemic heart diseases (IHD).
|
31574344 |
2019 |
|
Essential Tremor
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Peripheral BDNF/TrkB protein expression is decreased in Parkinson's disease but not in Essential tremor.
|
30723034 |
2019 |
|
Memory Loss
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Ribosylation-derived AGEs downregulated the BDNF-TrkB pathway in rat brains and N2a cells, leading to GSK-3β activation-mediated tau hyperphosphorylation, which was involved in the observed rat memory loss.
|
31381511 |
2019 |
|
Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
BDNF treatment reduced membrane TRKB-T1 protein and protected mice from diet-induced NASH.
|
31469911 |
2019 |
|
Fragile X Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Genetic reduction of brain-derived neurotrophic factor in FXS mouse progenitors diminishes the expression of Ca<sub>v</sub> channels and activity-dependent responses, which are associated with increased phosphorylation of the phospholipase C-γ1 site within TrkB receptors and changes of differentiating progenitor subpopulations.
|
30503263 |
2018 |
|
Disorder of the optic nerve
|
0.010 |
Biomarker
|
group |
BEFREE |
In this study, we tested the effects of LM22A-4, a small molecule TrkB receptor-specific partial agonist, on RGC survival in vitro and in experimental nonarteritic anterior ischemic optic neuropathy (AION), the most common acute optic neuropathy in those older than 50 years.
|
30273053 |
2018 |
|
Optic Neuropathy, Ischemic
|
0.010 |
Biomarker
|
disease |
BEFREE |
TrkB receptor partial agonist LM22A-4 promoted survival of cultured RGCs in vitro by TrkB receptor activation, and treatment in vivo led to increased survival of RGCs after optic nerve ischemia, providing support that LM22A-4 may be effective therapy to treat ischemic optic neuropathy.
|
30273053 |
2018 |
|
Uveal melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The hub gene SLC17A7, NTRK2, ABTB1 and ADPRHL1 might play a vital role in recurrence of uveal melanoma.
|
29031853 |
2018 |
|
Caffeine related disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Besides, our data revealed that caffeine intake since childhood attenuated behavioral alterations in the ADHD model associated with changes in BDNF and TrkB receptors in the hippocampus.
|
29557061 |
2018 |
|
Childhood Ganglioglioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Novel TLE4-NTRK2 fusion in a ganglioglioma identified by array-CGH and confirmed by NGS: Potential for a gene targeted therapy.
|
29502353 |
2018 |
|
Nonarteritic anterior ischemic optic neuropathy (NAION)
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we tested the effects of LM22A-4, a small molecule TrkB receptor-specific partial agonist, on RGC survival in vitro and in experimental nonarteritic anterior ischemic optic neuropathy (AION), the most common acute optic neuropathy in those older than 50 years.
|
30273053 |
2018 |
|
Optic Neuropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we tested the effects of LM22A-4, a small molecule TrkB receptor-specific partial agonist, on RGC survival in vitro and in experimental nonarteritic anterior ischemic optic neuropathy (AION), the most common acute optic neuropathy in those older than 50 years.
|
30273053 |
2018 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our findings suggest that heterodimerization of Her2 and TrkB receptors gives breast cancer cells a survival advantage in the brain and that dual inhibition of these receptors may hold therapeutic potential.
|
28446206 |
2017 |
|
Malignant neoplasm of larynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
These observations suggest that TrkB is a promising target for future intervention strategies to prevent tumor metastasis, EMT program in laryngeal cancer.What is already known about this subject?• Cancer of the larynx is one of the most common types of head and neck cancer.• The survival rate of advanced laryngeal cancer is only 30 to 40%.• The tropomyosin-related kinase B receptor (TrkB), together with TrkA and TrkC, are neurotrophin receptors regulating the proliferation and differentiation of neuronal cells.What are the new findings?• TrkB are overexpressed in laryngeal cancer.• TrkB signaling is involved in tumorigenicity of laryngeal cancer.• TrkB acts as a key regulator of the PI3K/AKT signal pathway-mediated tumor metastasis.How might these results change the focus of research or clinical practice?• These observations suggest that TrkB is a promising target for future intervention strategies to prevent tumor metastasis, EMT program in laryngeal cancer.
|
29312563 |
2017 |
|
Dementia, Vascular
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The present study generated a VD rat model, in which the effect of L‑NBP on neurological function and expression levels of brain‑derived neurotrophic factor (BDNF) and tyrosine kinase receptor B (TrkB) were observed.
|
28944854 |
2017 |
|
Panic Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits.
|
28761093 |
2017 |
|
Psychotic Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Depressive disorders accounted for this results and independent variables associated with depressive disorders in TLE were female sex (OR=2.59; 95%CI=1.15-5.82; p=0.021), presence of concomitant anxiety disorders (OR=3.72; 95%CI=1.71-8.06; p=0.001) or psychotic disorders (OR=3.86; 95%CI=1.12-13.25; p=0.032), A/A genotype in the rs1867283 NTRK2 gene (OR=3.06; 95%CI=1.25-7.50; p=0.015) and C/C genotype in the rs10868235 NTRK2 gene (OR=3.54; 1.55-8.08; p=0.003).
|
28550723 |
2017 |
|
Reflex Sympathetic Dystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Rats were randomly assigned to conditions of unrestricted sleep or selective REM sleep deprivation (RSD) with PPT microinjections of vehicle control or a dose of a TrkB receptor inhibitor (2, 3, or 4 nmol K252a or 4 nmol ANA-12).
|
28027399 |
2017 |
|
Asymmetric Septal Hypertrophy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
At the molecular level, ASH treatment was observed to restore the levels of BDNF and its receptor TRKB as well as the expression of other synaptic regulators, which are highly implicated in synaptic plasticity.
|
28253924 |
2017 |