Endothelial dysfunction
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
We aimed to investigate the relationships between serum asymmetric dimethyl arginine (ADMA), LOX-1, and Apelin-13 levels, which are known to act over nitric oxide with endothelial dysfunction and cardiac morphology as well as with each other in hemodialysis patients.
|
29205940 |
2018 |
Endothelial dysfunction
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Ginkgolide B ameliorates oxidized low-density lipoprotein-induced endothelial dysfunction via modulating Lectin-like ox-LDL-receptor-1 and NADPH oxidase 4 expression and inflammatory cascades.
|
30136446 |
2018 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Ox- LDL through LOX-1, in endothelial cells, causes increase in leukocyte adhesion molecules, activates pathways of apoptosis, increases reactive oxygen species and cause endothelial dysfunction.
|
29737246 |
2019 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Lectin-like oxidized low-density lipoprotein receptor-1 promotes endothelial dysfunction in LDL receptor knockout background.
|
29096854 |
2017 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Lectin-like oxidized LDL receptor-1 (LOX-1) is the major endothelial receptor for oxidized LDL (oxLDL), and uptake of oxLDL through LOX-1 induces ED.
|
15855339 |
2005 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Therapy of endothelial dysfunction through LOX-1 receptor antagonism will be an interesting avenue to explore.
|
14656932 |
2004 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Whether galectin-3 induces endothelial dysfunction through modulation of LOX-1-mediated signaling remains unclear.
|
30963716 |
2019 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Background When the lectinlike oxidized low-density lipoprotein (ox LDL) receptor-1 ( LOX -1), a scavenger receptor for ox LDL , binds ox LDL , processes leading to endothelial dysfunction and inflammation are promoted.
|
30744454 |
2019 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Whether CRP may regulate endothelial LOX-1 and induce endothelial dysfunction through this receptor is unknown.
|
15472120 |
2004 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results provide the first evidence that plasma from PE generates superoxide via a LOX1-NOX2-mediated pathway and downregulates endothelial KCa3.1, which may contribute to endothelial dysfunction and vasculopathy in preeclampsia.
|
23261940 |
2013 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis.
|
12163130 |
2002 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
LOX-1 has been demonstrated to contribute not only to endothelial dysfunction, but also to atherosclerotic-plaque formation, myocardial infarction and intimal thickening after balloon injury.
|
19801851 |
2009 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These preliminary data would suggest that in ICVD patients the LOX-1 isoform that induces internalization of ox-LDL is more frequent and a cascade of events responsible for endothelial dysfunction and injury.
|
19929426 |
2010 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
There are many scavenger receptors for ox-LDL, among which LOX-1 seems to be important for the induction of endothelial dysfunction and the other subsequent events that lead to the formation of atheromatous plaque.
|
23934117 |
2013 |
Endothelial dysfunction
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
These findings demonstrated for the first time that BBR could prevent the oxLDL and TNFα - induced LOX1 expression and oxidative stress, key events that lead to NOX, MAPK/Erk1/2 and NF-κB activation linked to endothelial dysfunction.
|
28511903 |
2017 |
Endothelial dysfunction
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The aim of the study was to investigate the relationship between the rs1050283 polymorphism in the 3'-UTR of OLR1/LOX-1 gene and endothelial dysfunction in 178 never-treated hypertensive patients and 36 healthy subjects.
|
23054405 |
2014 |
Endothelial dysfunction
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The LOX-1-ox-LDL interaction induces endothelial dysfunction, leukocyte adhesion, macrophage-derived foam cell formation, smooth muscle cell proliferation and migration, and platelet activation.
|
30381837 |
2019 |