OPRM1, opioid receptor mu 1, 4988

N. diseases: 370; N. variants: 42
Disease: Stress, Psychological ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological 		0.030 Biomarker disease BEFREE There is increasing evidence that neuropeptides such as a substance P, neurotrophins or beta-endorphin, an endogenous agonist for mu-opioid receptor, are involved in the pathogenesis of atopic dermatitis in which mental stress and scratching deteriorate the disease. mu-Opioid receptor, a G-protein-coupled receptor, can be downregulated and internalized by agonists and other factors in vitro. 15724090 2005
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological 		0.030 Biomarker disease BEFREE This current study is the first to find an interaction between OPRM1 and life stress that is associated with depression. 24766998 2014
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological 		0.030 Biomarker disease BEFREE Rats exposed to early life stress (MS360) had increased opioid receptor gene (Oprm1, Oprd1 and Oprk1) expression in the dorsal striatum. 28511993 2017