|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To evaluate whether individuals with alcoholism who are heterozygous (Asp40/Asn40) or homozygous (Asp40/Asp40) for the OPRM1 Asp40 allele respond better to naltrexone.
|
18250251 |
2008 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
Biomarker
|
disease |
BEFREE |
Mu opioid receptor (MOR) has been shown to be associated with alcoholism and opioid dependence.
|
11338173 |
2001 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results do not support association of the OPRM1 Asn40Asp polymorphism with NTX treatment response for AD.
|
17374034 |
2007 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The genotypes and allele frequencies of known polymorphisms in other alcoholism candidate genes, such as alcohol metabolism-related genes [alcohol dehydrogenase 2 (ADH2), aldehyde dehydrogenase 2 (ALDH2), alcohol dehydrogenase 3 (ADH3), and cytochrome P450 2E1 (CYP2E1)] and mu-opioid receptor gene (OPRM1), were studied.
|
15902904 |
2005 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our review showed that clinical studies do not unequivocally support an association between polymorphisms in OPRM1 and alcohol dependence.
|
17979515 |
2007 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results do not provide evidence that the common Asn40Asp substitution polymorphism of the OPRM gene contributes a major effect to the pathogenesis of alcohol dependence.
|
9884158 |
1998 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Simultaneous genotyping of single-nucleotide polymorphisms in alcoholism-related genes using duplex and triplex allele-specific PCR with two-step thermal cycles.
|
25382047 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Lack of associations of the opioid receptor mu 1 (OPRM1) rs1799971" genes_norm="4988">A118G polymorphism (rs1799971) with alcohol dependence: review and meta-analysis of retrospective controlled studies.
|
29070014 |
2017 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of a functional mu-opioid receptor allele (+118A) with alcohol dependency.
|
10490697 |
1999 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This analysis has 80% power to detect a small to moderate effect of OPRM1 variation on alcohol dependence and 100% power to detect effects of the magnitude of the ALDH2*2 variant.
|
9399694 |
1998 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The Asn40Asp variant (A118G) of the μ opioid receptor (OPRM1) gene is thought to contribute to the development and treatment of alcohol dependence.
|
22397905 |
2013 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We retrieved studies on the relationship between A118G polymorphism in OPRM1 gene and response to treatment with naltrexone in patients with alcohol dependence by means of electronic database search.
|
22515274 |
2012 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Variation at a single nucleotide polymorphism in the μ-opioid receptor gene (OPRM1), A118G (Asn40Asp), may moderate naltrexone (NTX) effects in alcohol dependence.
|
23032071 |
2013 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The association between the OPRM1 A118G (Asn40Asp, rs1799971) polymorphism and alcohol use disorders and alcohol consumption was analyzed using three different population-based samples: (a) a Finnish cohort study, Health 2000, with 503 participants having a DSM-IV diagnosis for alcohol dependence and/or alcohol abuse and 506 age- and sex-matched controls; (b) a Finnish cohort study, FINRISK (n = 2360) and (c) the Helsinki Birth Cohort Study (n = 1384).
|
23729673 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The functional polymorphism (A118G) of the mu-opioid receptor gene (OPRM1) is thought to have clinical significance in the treatment of alcohol dependence.
|
15252283 |
2004 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to investigate associations between 13 single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) with self-reported responses to alcohol, an endophenotype associated with the development of alcohol dependence, in American Indians living on eight contiguous reservations.
|
18433502 |
2008 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Subjective response to alcohol among alcohol-dependent individuals: effects of the μ-opioid receptor (OPRM1) gene and alcoholism severity.
|
23240711 |
2013 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Thus far, the most promising results were obtained for polymorphisms in the OPRM1 and CYP2A6 genes, which have been effective in predicting clinical response to naltrexone in alcoholism and nicotine replacement therapy in smoking, respectively.
|
21362114 |
2011 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The association between the OPRM1 A118G (rs1799971" genes_norm="4988">Asn40Asp, rs1799971) polymorphism and alcohol use disorders and alcohol consumption was analyzed using three different population-based samples: (a) a Finnish cohort study, Health 2000, with 503 participants having a DSM-IV diagnosis for alcohol dependence and/or alcohol abuse and 506 age- and sex-matched controls; (b) a Finnish cohort study, FINRISK (n = 2360) and (c) the Helsinki Birth Cohort Study (n = 1384).
|
23729673 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In central Sweden, the functional variant 118G allele in exon 1 of OPRM1 is associated with an increased attributable risk for alcohol dependence.
|
15525999 |
2005 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
Biomarker
|
disease |
BEFREE |
Reduced MOR is interpreted as a neuroadaptation to an alcohol-induced release of endogenous ligands in patients with severe alcoholism.
|
27510425 |
2017 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Twenty individuals with alcohol dependence (six females; 90% Caucasian; mean age = 29.4) who were prospectively genotyped on the OPRM1 gene underwent blood oxygen level-dependent functional magnetic resonance imaging while performing a Stop-Signal Task.
|
23240858 |
2013 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recent clinical and laboratory studies have shown that the effects of naltrexone for alcoholism may be moderated by the Asn40Asp single-nucleotide polymorphism (SNP) of the μ-opioid receptor gene (OPRM1).
|
21900886 |
2012 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Thus, variants of the mu-opioid receptor (muOR) gene may confer vulnerability to alcohol dependence.
|
11522434 |
2001 |
|
Alcoholic Intoxication, Chronic
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Influence of the OPRM1 A118G polymorphism on alcohol-induced euphoria, risk for alcoholism and the clinical efficacy of naltrexone.
|
22909206 |
2012 |