Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.020 Biomarker group BEFREE CD95L expression was characterized in immortalized squamous esophagus (HET-1A) and Barrett esophagus (BAR-T) cells; adenocarcinoma cell lines FLO-1, SEG-1, and BIC-1, and MDA468 (- control); and KFL cells (+ control). 21390183 2011
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.020 Biomarker group BEFREE Human esophageal squamous epithelial (HET-1A) and adenocarcinoma (OE33) cells were subjected to acid treatment and used in transfection experiments. 20138038 2010
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.030 AlteredExpression disease BEFREE SLC22A18, solute carrier family 22, member 18, has been proposed to function as a tumor suppressor based on its chromosomal location at 11p15.5, mutations and aberrant splicing in several types of cancer and down-regulation in glioblastoma. 26196590 2015
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.030 AlteredExpression disease BEFREE Predictive value of the SLC22A18 protein expression in glioblastoma patients receiving temozolomide therapy. 23514245 2013
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.030 AlteredExpression disease BEFREE Silencing SATB1 overcomes temozolomide resistance by downregulating MGMT expression and upregulating SLC22A18 expression in human glioblastoma cells. 30140041 2018
CUI: C0279550
Disease: Adult Rhabdomyosarcoma
Adult Rhabdomyosarcoma 		0.010 GeneticVariation disease BEFREE Because this region frequently is altered in neoplasms and in the genetic disease Beckwith-Wiedemann syndrome, we carried out a mutational analysis in tumor cell lines and Beckwith-Wiedemann syndrome samples that resulted in the identification of genetic alterations in the BWR1A gene: an insertion that introduced a stop codon in the breast cancer cell line BT549 and a point mutation in the rhabdomyosarcoma cell line TE125-T. 9520460 1998
CUI: C0563625
Disease: Agnosia for Pain
Agnosia for Pain 		0.010 Biomarker disease BEFREE Eighty patients were randomized to receive either intrathecal morphine (Group ITM) or local infiltration analgesia (Group LIA) for pain management in a double-blind study. 28856511 2017
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.300 Biomarker disease PSYGENET Combining evidence from the case-control study, the follow-up in families, and gene expression provided strongest support for the association of a cluster of genes on chromosome 11 (SLC22A18, PHLDA2, NAP1L4, SNORA54, CARS, and OSBPL5) with alcohol dependence. 20201924 2010
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.010 Biomarker disease BEFREE Atherosclerosis was diagnosed by (carotid and femoral) ITM measurement and ABPI. 28146208 2017
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.010 Biomarker disease BEFREE Atherosclerosis was diagnosed by (carotid and femoral) ITM measurement and ABPI. 28146208 2017
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.010 GeneticVariation group BEFREE Polymorphisms of the NACHT [neuronal apoptosis inhibitory protein (NAIP), CIITA, HET-E, TP1] and leucine-rich repeat protein 1 (NLRP1) gene are reported to be associated with susceptibility to vitiligo and several autoimmune diseases. 21331694 2011
CUI: C0004763
Disease: Barrett Esophagus
Barrett Esophagus 		0.050 AlteredExpression disease BEFREE Normal esophageal epithelium and HET-1A cells (derived from normal squamous epithelium) show high levels of Beclin-1, but lower levels of Beclin-1 were found in BE and EAC cell lines (CP-A, CP-C, and OE33). 22301112 2012
CUI: C0004763
Disease: Barrett Esophagus
Barrett Esophagus 		0.050 Biomarker disease BEFREE One such gene, tribbles-homology-3 (TRB3) was induced specifically in HET-1A cells, absent in SKGT4 cells and decreased in BO samples in silico and in vivo. 20139130 2010
CUI: C0004763
Disease: Barrett Esophagus
Barrett Esophagus 		0.050 Biomarker disease BEFREE The proliferative effect of miRNA-145 precursor transfection in the SQ (HET-1A) and BE cell line (BAR-T) was measured. 22504665 2013
CUI: C0004763
Disease: Barrett Esophagus
Barrett Esophagus 		0.050 Biomarker disease BEFREE Cell line models of squamous epithelium (HET-1A) and BO (QH) were used to examine the effects of bile acids on cell adhesion to extracellular matrix proteins (Collagen, laminin, vitronectin, fibronectin) and expression of integrin ligands (α<sub>3</sub> , α<sub>4,</sub> α<sub>5</sub> , α<sub>6</sub> and α<sub>ν</sub> ). 28941013 2017
CUI: C0004763
Disease: Barrett Esophagus
Barrett Esophagus 		0.050 Biomarker disease BEFREE CD95L expression was characterized in immortalized squamous esophagus (HET-1A) and Barrett esophagus (BAR-T) cells; adenocarcinoma cell lines FLO-1, SEG-1, and BIC-1, and MDA468 (- control); and KFL cells (+ control). 21390183 2011
CUI: C1332460
Disease: Barrett's Adenocarcinoma
Barrett's Adenocarcinoma 		0.010 Biomarker disease BEFREE Hsp27 protein was inducible by heat shock in Barrett's adenocarcinoma cell lines and an immortalized oesophageal epithelial cell line (HET-1A), but not by oestradiol. 10027336 1999
CUI: C0004903
Disease: Beckwith-Wiedemann Syndrome
Beckwith-Wiedemann Syndrome 		0.010 GeneticVariation disease BEFREE Because this region frequently is altered in neoplasms and in the genetic disease Beckwith-Wiedemann syndrome, we carried out a mutational analysis in tumor cell lines and Beckwith-Wiedemann syndrome samples that resulted in the identification of genetic alterations in the BWR1A gene: an insertion that introduced a stop codon in the breast cancer cell line BT549 and a point mutation in the rhabdomyosarcoma cell line TE125-T. 9520460 1998
CUI: C1287365
Disease: Bilirubin level result
Bilirubin level result 		0.100 GeneticVariation phenotype GWASDB Genome-wide association meta-analysis for total serum bilirubin levels. 19414484 2009
CUI: C0344395
Disease: Bilirubin measurement
Bilirubin measurement 		0.100 GeneticVariation phenotype GWASDB Genome-wide association meta-analysis for total serum bilirubin levels. 19414484 2009
CUI: C0344395
Disease: Bilirubin measurement
Bilirubin measurement 		0.100 GeneticVariation phenotype GWASCAT Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. 29403010 2018
CUI: C0344395
Disease: Bilirubin measurement
Bilirubin measurement 		0.100 GeneticVariation phenotype GWASCAT Genome-wide association meta-analysis for total serum bilirubin levels. 19414484 2009
CUI: C0346153
Disease: Breast Cancer, Familial
Breast Cancer, Familial 		0.300 GeneticVariation disease ORPHANET
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.460 AlteredExpression disease BEFREE The results of Kaplan-Meier analysis indicated that SLC22A18 expression was associated with relapse-free survival (RFS) of breast cancer. 21144813 2011
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.460 Biomarker disease CTD_human