PARN, poly(A)-specific ribonuclease, 5073

N. diseases: 144; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2132198
Disease: Abnormal blistering of the skin
Abnormal blistering of the skin 		0.100 Biomarker phenotype HPO
CUI: C4011556
Disease: Abnormal eyebrow morphology
Abnormal eyebrow morphology 		0.100 Biomarker group HPO
CUI: C2675111
Disease: Abnormal eyelash morphology
Abnormal eyelash morphology 		0.100 Biomarker phenotype HPO
CUI: C1260926
Disease: Abnormal pigmentation
Abnormal pigmentation 		0.100 Biomarker phenotype HPO
CUI: C1846821
Disease: Abnormality of coagulation
Abnormality of coagulation 		0.100 Biomarker phenotype HPO
CUI: C4025900
Disease: Abnormality of female internal genitalia
Abnormality of female internal genitalia 		0.100 Biomarker disease HPO
CUI: C4025838
Disease: Abnormality of the pharynx
Abnormality of the pharynx 		0.100 Biomarker disease HPO
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.010 Biomarker disease BEFREE Alterations of deadenylase expression in acute leukemias: evidence for poly(a)-specific ribonuclease as a potential biomarker. 22614729 2012
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia 		0.010 PosttranslationalModification disease BEFREE Further analysis revealed that a significant amount of PARN is phosphorylated in ALL. 22614729 2012
CUI: C0751606
Disease: Adult Acute Lymphocytic Leukemia
Adult Acute Lymphocytic Leukemia 		0.010 PosttranslationalModification disease BEFREE Further analysis revealed that a significant amount of PARN is phosphorylated in ALL. 22614729 2012
CUI: C0002170
Disease: Alopecia
Alopecia 		0.100 Biomarker disease HPO
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.010 AlteredExpression disease BEFREE Tau, Pin1 and PARN target the expression of mRNAs deregulated in AD and/or cancer. 31749682 2019
CUI: C0002871
Disease: Anemia
Anemia 		0.100 Biomarker disease HPO
CUI: C3495676
Disease: Anorectal Malformations
Anorectal Malformations 		0.100 Biomarker group HPO
CUI: C4024737
Disease: Aplasia/Hypoplasia of the skin
Aplasia/Hypoplasia of the skin 		0.100 Biomarker phenotype HPO
CUI: C1856749
Disease: Aplastic/hypoplastic toenail
Aplastic/hypoplastic toenail 		0.100 Biomarker phenotype HPO
CUI: C0085660
Disease: Aseptic necrosis
Aseptic necrosis 		0.100 Biomarker phenotype HPO
CUI: C0004134
Disease: Ataxia
Ataxia 		0.100 Biomarker phenotype HPO
CUI: C0151514
Disease: Atrophic condition of skin
Atrophic condition of skin 		0.100 Biomarker group HPO
CUI: C3887513
Disease: Avascular necrosis
Avascular necrosis 		0.100 Biomarker phenotype HPO
CUI: C0027543
Disease: Avascular necrosis of bone
Avascular necrosis of bone 		0.100 Biomarker phenotype HPO
CUI: C4553018
Disease: Avascular Necrosis, CTCAE
Avascular Necrosis, CTCAE 		0.100 Biomarker phenotype HPO
CUI: C0005741
Disease: Blepharitis
Blepharitis 		0.100 Biomarker disease HPO
CUI: C1855710
Disease: Bone marrow hypocellularity
Bone marrow hypocellularity 		0.100 Biomarker phenotype HPO
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.010 AlteredExpression disease BEFREE Co-expression of both PARN and PLD2 mimicked this pattern in non-cancerous cells (COS-7 fibroblasts) but, surprisingly, not in breast cancer MCF-7 cells, where PARN switches from inhibition to activation of PLD2 gene and protein expression. 28011629 2017