|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Par-4 but not Bcl-2 was detected in the secretory epithelium of benign prostatic tumors and in primary and metastatic prostate cancers that are apt to undergo apoptosis.
|
9989812 |
1999 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Importantly, restoration of Par-4 levels to normal in Ras-transformed cells makes these cells sensitive to the pro-apoptotic actions of tumor necrosis factor-alpha under conditions in which PI 3-kinase is inhibited and also severely impairs colony formation in soft agar and tumor development in nude mice, as well as increases the sensitivity of these tumors to camptothecin.
|
10562548 |
1999 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression.
|
11585763 |
2001 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Prostate apoptosis response-4 (Par-4) is a unique pro-apoptotic molecule that is capable of selectively inducing apoptosis in cancer cells when over-expressed, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models.
|
14755681 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
After several months the indolent WT1-LNCaP cells became proliferative forming small tumors lacking par-4 protein.
|
14767530 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Co-expression of Par-4 and a dominant-negative mutant of FADD resulted in a slight reduction of apoptosis in some tumor cell lines, indicating that Par-4 may partially induce apoptosis via the Fas death pathway.
|
15586236 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Together, these data show that Par-4 is a relevant tumor suppressor gene in human endometrial carcinogenesis.
|
17332319 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This review emphasizes the role of Par-4/SAC in apoptosis and tumor resistance.
|
18836307 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor suppressor Par-4 is an important negative regulator of the canonical NF-kappaB pathway and is highly expressed in prostate.
|
19470463 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor suppressor Par-4 is a novel integral player in the PTEN network.
|
19625770 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These nanoliposomes were used to deliver Par-4 plasmid to tumors growing in nude mice from wild type HT29 cells.
|
19729995 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results therefore identify a key strd-1/STRAD-independent function of par-4/LKB1 in polarity establishment that is likely to be important for tumour suppression in humans.
|
20110331 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The level of Par-4 protein as well as the Par-4 binding protein, GRP78, was increased in wild-type cells growing in the same mouse as Par-4-overexpressing tumors compared with wild-type tumors growing without Par-4-overexpressing tumors.
|
21555373 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, recombinant Par-4 inhibits the growth of tumors in mice.
|
22552839 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We have uncovered a novel mechanism of 3-azidoWA induced extracellular pro-apoptotic candidate tumor suppressor Par-4 protein stimulation in conditioned media and also noticed a concomitant marked reduction in pAkt and pERK signaling by immunoblot analysis.
|
22962598 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Analysis of tumor remnants showed that KPT-330 disrupted the interaction between CRM-1 and PAR-4, activated PAR-4 signaling, and reduced proliferation of tumor cells.
|
23089203 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PAWR is a tumor suppressing gene essential for apoptosis and a cancer-selective target for cancer therapeutics.
|
23583662 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PAR4 may acts as a tumor suppressor in lung adenocarcinoma.
|
23886184 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The proapoptotic protein, prostate apoptosis response-4 (Par-4), acts as a tumor suppressor in prostate cancer cells.
|
24457960 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, WIN effects were not associated with a canonical apoptotic pathway, as demonstrated by the absence of specific features, and only the addition of TRAIL to WIN-treated cells led to apoptotic death probably mediated by up-regulation of the tumor suppressor factor PAR-4, whose levels increased after WIN treatment, and by the translocation of GRP78 on cell surface.
|
24795528 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival.
|
24992930 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Par-4 is one such tumor suppressor which is unique in its ability to selectively induce apoptosis in cancer cells while leaving the normal cells unaffected.
|
25001535 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor suppressor prostate apoptosis response-4 (Par-4) is regulated by mutant IDH1 and kills glioma stem cells.
|
25135281 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Prostate apoptosis response-4 (PAR-4) is considered as a tumour suppressor due to its ability to selectively induce cell apoptosis in most cancer cells.
|
26246468 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Oral administration of WA to mice with xenograft tumors restores FOXO3a-mediated Par-4 functions and results in inhibited tumor growth.
|
26913603 |
2016 |