Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression.
|
24334454 |
2014 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Identification of target genes of PAX3-FOXO1 in alveolar rhabdomyosarcoma.
|
23733015 |
2013 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The Pax3-FKHR fusion protein is present in alveolar rhabdomyosarcoma and results from the t(2;13) (q35;q14) chromosomal translocation.
|
10393185 |
1999 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
<i>PPP2R1A</i> regulated by PAX3/FOXO1 fusion contributes to the acquisition of aggressive behavior in PAX3/FOXO1-positive alveolar rhabdomyosarcoma.
|
29861864 |
2018 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
P-cadherin is a direct PAX3-FOXO1A target involved in alveolar rhabdomyosarcoma aggressiveness.
|
22710718 |
2013 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The alveolar rhabdomyosarcoma PAX3/FKHR fusion protein is a transcriptional activator.
|
7630639 |
1995 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
With the difficulties in morphological diagnosis of alveolar rhabdomyosarcoma on increasingly used small needle biopsy specimens, these data suggest that molecular analysis for PAX3-FKHR will be a clinically useful tool in treatment stratification in the future.
|
11556833 |
2001 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In vivo amplification of the PAX3-FKHR and PAX7-FKHR fusion genes in alveolar rhabdomyosarcoma.
|
8789435 |
1996 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Effects of PAX3-FKHR on malignant phenotypes in alveolar rhabdomyosarcoma.
|
18022385 |
2008 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
These assays detect PAX3-FKHR and PAX7-FKHR chimeric transcripts in alveolar rhabdomyosarcoma, EWS-FLI1 and EWS-ERG chimeric transcripts in Ewing's sarcoma, and EWS-WT1 chimeric transcripts in desmoplastic small round cell tumor.
|
7530783 |
1995 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Somatic genetic rearrangements that juxtapose the PAX3 DNA binding domain to the transcriptional activation domain of other transcription factors deregulate PAX3 function and contribute to the pathogenesis of the soft tissue cancers alveolar rhabdomyosarcoma and biphenotypic sinonasal sarcoma.
|
29730428 |
2018 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
RGD liposome-protamine-siRNA (LPR) nanoparticles targeting PAX3-FOXO1 for alveolar rhabdomyosarcoma therapy.
|
27261335 |
2016 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
These results suggest that Pax3 may suppress the terminal differentiation of migrating limb myoblasts and that the PAX3-forkhead fusion may contribute to the phenotype of alveolar rhabdomyosarcoma by preventing terminal differentiation.
|
7744814 |
1995 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
PAX-3-FORKHEAD chimeric mRNAs were amplified by PCR in 8 of 15 cases of alveolar rhabdomyosarcoma.
|
8943815 |
1996 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Prognostic value of PAX3/7-FOXO1 fusion status in alveolar rhabdomyosarcoma: Systematic review and meta-analysis.
|
26008753 |
2015 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma.
|
8275086 |
1993 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Gene expression profiling identifies potential relevant genes in alveolar rhabdomyosarcoma pathogenesis and discriminates PAX3-FKHR positive and negative tumors.
|
16381018 |
2006 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
PAX3-FOXO1 drives miR-486-5p and represses miR-221 contributing to pathogenesis of alveolar rhabdomyosarcoma.
|
29367756 |
2018 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
We previously identified the class I-specific histone deacetylase inhibitor, entinostat (ENT), as a pharmacological agent that transcriptionally suppresses the PAX3:FOXO1 tumor-initiating fusion gene found in alveolar rhabdomyosarcoma (aRMS), and we further investigated the mechanism by which ENT suppresses PAX3:FOXO1 oncogene and demonstrated the preclinical efficacy of ENT in RMS orthotopic allograft and patient-derived xenograft (PDX) models.
|
31113472 |
2019 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The chromosomal translocation that leads to alveolar rhabdomyosarcoma development generates a novel TAD that is likely to favour ectopic PAX3:FOXO1 oncogene activation in non-PAX3 territories.
|
28615069 |
2017 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
MGD |
|
|
|
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma.
|
8098985 |
1993 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
To better understand the molecular pathogenesis of PAX3-FKHR, we carried out the first, unbiased genome-wide identification of PAX3-FKHR binding sites and associated target genes in alveolar rhabdomyosarcoma.
|
20663909 |
2010 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma.
|
11863357 |
2002 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
A call to ARMS: targeting the PAX3-FOXO1 gene in alveolar rhabdomyosarcoma.
|
23432728 |
2013 |