Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group.
|
12039929 |
2002 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
PAX3-FKHR results from a t(2,13) chromosomal translocation, a unique genetic marker of alveolar rhabdomyosarcoma.
|
12401804 |
2003 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We report the first mouse model of alveolar rhabdomyosarcoma using a conditional Pax3:Fkhr knock-in allele whose activation in late embryogenesis and postnatally is targeted to terminally differentiating Myf6-expressing skeletal muscle.
|
15489287 |
2004 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Lack of effective T-lymphocyte response to the PAX3/FKHR translocation area in alveolar rhabdomyosarcoma.
|
15838707 |
2005 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Gene expression profiling identifies potential relevant genes in alveolar rhabdomyosarcoma pathogenesis and discriminates PAX3-FKHR positive and negative tumors.
|
16381018 |
2006 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
This work highlights the potential of PAX3-FKHR to functionally operate as a deregulated Pangene and may have implications with regard to the identity of the precursor cell giving rise to alveolar rhabdomyosarcoma.
|
17490646 |
2007 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Effects of PAX3-FKHR on malignant phenotypes in alveolar rhabdomyosarcoma.
|
18022385 |
2008 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A valuable diagnostic aid and important prognostic parameter in alveolar rhabdomyosarcoma is the identification of PAX3-FOXO1 [t(2;13)(q35;q14)] or PAX7-FOXO1 [t(1;13)(p36;q14)] rearrangements.
|
18973919 |
2009 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Both areas showed diffuse nuclear expression for myogenin, and both areas expressed the PAX3-FKHR fusion gene, a genetic change associated with alveolar but not embryonal RMS.
|
19175284 |
2009 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In humans, mutations in the PAX3 gene cause Waardenburg syndrome, whereas a chromosomal translocation that generates a PAX3-FOXO1 fusion gene is associated with the development of alveolar rhabdomyosarcoma.
|
19199574 |
2009 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
One example for such a tumor type is alveolar rhabdomyosarcoma (aRMS), which is characterized by a specific translocation creating the oncogenic PAX3/FKHR transcription factor, believed to be the molecular basis of the disease.
|
20453878 |
2010 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
To better understand the molecular pathogenesis of PAX3-FKHR, we carried out the first, unbiased genome-wide identification of PAX3-FKHR binding sites and associated target genes in alveolar rhabdomyosarcoma.
|
20663909 |
2010 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Alveolar rhabdomyosarcoma (ARMS) is characterized by the t(2;13) or t(1;13) chromosomal translocations, which generate the PAX3-FOXO1 or PAX7-FOXO1 fusion genes, respectively.
|
21177767 |
2011 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
PAX3-FOXO1 and FGFR4 in alveolar rhabdomyosarcoma.
|
21882254 |
2012 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Alveolar rhabdomyosarcoma (RMS) is an aggressive pediatric cancer of the myogenic lineage with frequent chromosomal translocations involving the PAX3 or PAX7 and FOXO1 genes.
|
22447499 |
2012 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
P-cadherin is a direct PAX3-FOXO1A target involved in alveolar rhabdomyosarcoma aggressiveness.
|
22710718 |
2013 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
A call to ARMS: targeting the PAX3-FOXO1 gene in alveolar rhabdomyosarcoma.
|
23432728 |
2013 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Regulation of target genes of PAX3-FOXO1 in alveolar rhabdomyosarcoma.
|
23645752 |
2013 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Identification of target genes of PAX3-FOXO1 in alveolar rhabdomyosarcoma.
|
23733015 |
2013 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Therapeutic cytodifferentiation in alveolar rhabdomyosarcoma without genetic change of the PAX3-FKHR chimeric fusion gene: a case study.
|
23797277 |
2013 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression.
|
24334454 |
2014 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Taken together, these preclinical studies validate the PLK1-PAX3-FOXO1 axis as a rational target to treat aRMS.
|
25398439 |
2015 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The reciprocal t(2;13)(q36.1;q14.1) in human alveolar rhabdomyosarcoma (A-RMS) creates a pathognomonic PAX3-FOXO1 fusion gene.
|
25659124 |
2015 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Prognostic value of PAX3/7-FOXO1 fusion status in alveolar rhabdomyosarcoma: Systematic review and meta-analysis.
|
26008753 |
2015 |
Childhood Alveolar Rhabdomyosarcoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The presence of PAX3-FOXO1 in SNS and alveolar rhabdomyosarcoma suggests that these two entities are genetically similar lesions arising from distinct progenitor cell pools.
|
26355893 |
2016 |