Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
Analysis of positional candidate genes strongly supported CTLA-4 as the gene on 2q associated with APS3v and FOXP3 as the gene on Xp associated with T1D or AITD and APS3v.
|
19141582 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Poor in vitro induction of FOXP3 and ICOS in type 1 cytokine environment activated T-cells from children with type 1 diabetes.
|
18973208 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data showed that the (GT)n microsatelloite polymorphism in the FOXP3/Scrufin gene was associated with Japanese adult onset type 1 diabetes, especially in females, and slowly progressive type 1 diabetes.
|
19085184 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Patients with CD and T1D had higher expression of FOXP3 mRNA than patients with CD alone (p=0.02).
|
19096978 |
2009 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
This study shows the possible role of FoxP3 in the development of tissue characteristic humoral immunity in type 1 diabetes.
|
19132983 |
2008 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
Infiltration of forkhead box P3-expressing cells in small intestinal mucosa in coeliac disease but not in type 1 diabetes.
|
18435801 |
2008 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
These include certain alleles of the cytotoxic T lymphocyte-associated antigen-4 gene (possibly a nonspecific exacerbating molecule of disease risk in several autoimmune diseases), the lymphoid protein tyrosine phosphatase nonreceptor type 22 gene (associated with type 1 diabetes and other autoimmune diseases), TNF-alpha (involved in chronic inflammation, autoimmunity and malignancies) and the FOXP3 gene (expressed by CD4+C25+ regulatory T cells), whose mutations can cause immune dysregulation, polyendocrinopathy and X-linked inheritance syndromes of systemic autoimmunity.
|
18324481 |
2008 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, children with only T1D generally showed a lower FOXP3 mRNA expression than did children with CD, or with T1D in combination with CD, which suggests impaired regulation of the immune system in children with T1D.
|
19120312 |
2008 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
These investigations suggest that altered peripheral blood frequencies of Tregs, as defined by the expression of FOXP3, are not specifically associated with type 1 diabetes and continue to highlight age as an important variable in analysis of immune regulation.
|
17327427 |
2007 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A recent study showed that the presence of the (GT) n microsatellite polymorphism in the FOXP3 gene was associated with enhancer activity, resulting in an effect on type I diabetes mellitus.
|
18496979 |
2007 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
Foxp3-transduced CD4(+)T-cells have been used for treating autoimmune diseases such as type I diabetes.
|
17534268 |
2007 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
While some progress has been made towards these goals, additional investigations are needed to address the aforementioned knowledge voids including the role for regulatory T cells (Treg), defined by their co-expression of CD4 and CD25 as well as the transcription factor FOXP3, in the pathogenesis and natural history of type 1 diabetes.
|
17709886 |
2007 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results indicated an association between FOXP3 and T1D (global p=0.004) and a possible interaction between FOXP3 and the HLA-DR3-DQ2 susceptibility haplotype.
|
16996248 |
2006 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data indicate that allelic variation in or near the coding regions of the FOXP3 gene does not have a major role in the inherited susceptibility to the common form of type 1 diabetes.
|
15220219 |
2004 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
BEFREE |
Next, we performed an association study between the FOXP3/Scurfin gene and type 1 diabetes.
|
12750858 |
2003 |
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Diabetes Mellitus, Insulin-Dependent
|
0.500 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|