PDE3A, phosphodiesterase 3A, 5139

N. diseases: 58; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.160 Biomarker group BEFREE Our results shed more light on phosphodiesterase 3A activation and could be relevant to the treatment of severe hypertension in the general population. 26283042 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.160 GeneticVariation group BEFREE Hypertension linked to PDE3A activation. 26018892 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.160 AlteredExpression group BEFREE VSMC-expressed PDE3A deserves scrutiny as a therapeutic target for the treatment of hypertension. 25961942 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.160 AlteredExpression group BEFREE The differences in PDE3A expression and responses may be the result of hypertension rather than the cause. 14707163 2004
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.160 Biomarker group HPO
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke 		0.120 GeneticVariation disease BEFREE PDE3A variant associated with hypertension and brachydactyly syndrome in a patient with ischemic stroke caused by spontaneous intracranial artery dissection: A review of the clinical and molecular genetic features. 31589936 2019
CUI: C0221357
Disease: Brachydactyly
Brachydactyly 		0.120 GeneticVariation disease BEFREE We report a novel PDE3A gene mutation in a mother and daughter affected with dominant brachydactyly of the hands and feet, a short stature, and hypertension. 30209282 2018
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke 		0.120 GeneticVariation disease GWASCAT Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. 29531354 2018
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke 		0.120 Biomarker disease BEFREE As an initial step in the development of a therapy that simultaneously treats CMB and ischemic stroke, we hypothesized that inhibition of the PDE3A pathway is protective against CMH development. 28583195 2017
CUI: C0221357
Disease: Brachydactyly
Brachydactyly 		0.120 GeneticVariation disease BEFREE A new study identifies PDE3A mutations as the cause of brachydactyly type E with hypertension. 26018892 2015
CUI: C0221357
Disease: Brachydactyly
Brachydactyly 		0.120 Biomarker disease HPO
CUI: C0005890
Disease: Body Height
Body Height 		0.100 GeneticVariation phenotype GWASCAT Characterizing rare and low-frequency height-associated variants in the Japanese population. 31562340 2019
CUI: C0005890
Disease: Body Height
Body Height 		0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0023508
Disease: White Blood Cell Count procedure
White Blood Cell Count procedure 		0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0424678
Disease: Lean body mass
Lean body mass 		0.100 GeneticVariation phenotype GWASCAT Genomics of body fat percentage may contribute to sex bias in anorexia nervosa. 30593698 2019
CUI: C0871470
Disease: Systolic Pressure
Systolic Pressure 		0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0005890
Disease: Body Height
Body Height 		0.100 GeneticVariation phenotype GWASCAT Evaluation and application of summary statistic imputation to discover new height-associated loci. 29782485 2018
CUI: C0005890
Disease: Body Height
Body Height 		0.100 GeneticVariation phenotype GWASCAT Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits. 28552196 2017
CUI: C0001948
Disease: Alcohol consumption
Alcohol consumption 		0.100 GeneticVariation phenotype GWASCAT Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9. 24376456 2013
CUI: C0871470
Disease: Systolic Pressure
Systolic Pressure 		0.100 GeneticVariation phenotype GWASCAT Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9. 24376456 2013
CUI: C0202236
Disease: Triglycerides measurement
Triglycerides measurement 		0.100 GeneticVariation phenotype GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.100 GeneticVariation phenotype GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
CUI: C0428472
Disease: Serum HDL cholesterol measurement
Serum HDL cholesterol measurement 		0.100 GeneticVariation phenotype GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.100 GeneticVariation disease GWASDB A genome-wide association study for diabetic nephropathy genes in African Americans. 21150874 2011
CUI: C0489786
Disease: Height
Height 		0.100 GeneticVariation phenotype GWASDB Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. 21194676 2011