|
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
No allele of the microsatellite marker, showed association to stroke or any subtype and nor did the Icelandic PDE4D at-risk haplotype (GA0).
|
17655870 |
2007 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Studies from the different ethnic regions of world have reported variable results on association of Apolioprotein E (APOE), Methylenetetrahydrofolate reductase (MTHFR), Endothelial Nitric Oxide Synthase (ENOS), Factor V Leiden (F5), Cytochrome P450 4F2 (CYP4F2), beta-fibrinogen and Phosphodiesterase 4D (PDE4D) gene in stroke.
|
24090469 |
2013 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
The phosphodiesterase-4D (PDE4D) and the 5-lipoxygenase activating protein (ALOX5AP) genes were identified as contributors to stroke in an Icelandic population.
|
19417766 |
2009 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Our findings support that SNP83 of PDE4D is a genetic risk factor for atherothrombotic strokes in a Chinese population.
|
18694398 |
2009 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Accumulating evidences have shown that inhibition of PDE4 is beneficial for the functional recovery after cerebral ischemia; i. subtype D of PDE4 (PDE4D) is viewed as a risk factor for ischemic stroke; ii. inhibition of PDE4 enhances neurological behaviors, such as learning and memory, after stroke in rodents; iii.PDE4 inhibition increases dendritic density, synaptic plasticity and neurogenesis; iv. activation of cAMP/CREB signaling by PDE4 inhibition causes an endogenous increase of BDNF, which is a potent modulator of neuroplasticity; v. PDE4 inhibition is believed to restrict neuroinflammation during ischemic stroke.
|
30416389 |
2018 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
PDE4D is the first putative gene associated with common polygenic stroke.
|
18705898 |
2008 |
|
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Several single nucleotide polymorphisms within the phosphodiesterase 4D gene have been implicated in the pathogenesis of stroke.
|
21989204 |
2011 |
|
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
These data are consistent with an association of the PDE4D gene with stroke in a non-Icelandic sample and suggest an effect of hypertension status.
|
16675738 |
2006 |
|
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Association of SNP41, SNP56 and a novel SNP in PDE4D gene with stroke and its subtypes.
|
22771915 |
2012 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Studies have also noticeably highlighted that PDE4D gene/pathway can be a suitable drug target for managing stroke; however, a more comprehensive research is still required to understand the molecular and cellular intricacies this gene plays in stroke development, progression and its outcome.
|
26004910 |
2016 |
|
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Phosphodiesterase 4D polymorphisms and the risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study.
|
16835261 |
2006 |
|
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
In conclusion, the -889 C/T and SNP83 T/C SNPs of the IL-1alpha and PDE4D genes, respectively, appear to be genetic risk factors for stroke in our study population.
|
18158110 |
2008 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
In the present paper, we review both current issues and progress in the isolation of susceptibility genes for ischemic stroke, with particular emphasis on the PDE4D gene in the STRK1 region of 5q12.
|
18220751 |
2007 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
Studies that employ genome-wide linkage scans with hundreds of small nuclear families have identified new susceptibility genes for coronary artery disease and myocardiaI infarction, including ALOX5AP (encoding 5-lipoxygenase-activating protein) associated with myocardial infarction and stroke and PDE4D (encoding phosphodiesterase 4D) for ischemic stroke.
|
15861005 |
2005 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
The present study adds further support to the role of PDE4D in stroke.
|
19196240 |
2009 |
|
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Phosphodiesterase4D (PDE4D)--A risk factor for atrial fibrillation and stroke?
|
26671126 |
2015 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
The previously established association of a PDE4D gene haplotype with ischaemic stroke in a population from Iceland was independently confirmed in our Greek population, suggesting that PDE4D may be involved in the aetiology and pathogenesis of stroke.
|
17594329 |
2007 |
|
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Our study of Australian patients with stroke showed an independent association between ischaemic stroke and PDE4D SNP 89 (CC: odds ratio (OR) 5.55, 95% confidence interval (CI) 1.02 to 30.19; CA: OR 1.68, 95% CI 0.96 to 2.96; AA: OR 1 (reference)), SNP 87 (CC: OR 2.13, 95% CI 1.08 to 4.20; TC: OR 1.64, 95% CI 0.89 to 3.00; TT: OR 1 (reference)) and SNP 83 (TT: OR 2.16, 95% CI 1.08 to 4.32; TC: OR 1.37, 95% CI 0.77 to 2.43; CC: OR 1 (reference)), and between ischaemic stroke and PDE4D haplotypes at SNP 89-87-83 (A-C-C: OR 2.13, 95% CI 1.15 to 3.96; C-C-T: OR 2.25, 95% CI 1.29 to 3.92), but no association between ischaemic stroke and PDE4D SNP 56, SNP 45 or SNP 41, or with PDE4D haplotypes at SNP 56-45-41.
|
16914755 |
2006 |
|
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Variants in the PDE4D gene are not a major risk factor for stroke in individuals from central Europe.
|
15731479 |
2005 |
|
Cerebrovascular accident
|
0.300 |
Biomarker
|
group |
BEFREE |
We propose that PDE4D is involved in the pathogenesis of stroke, possibly through atherosclerosis, which is the primary pathological process underlying ischemic stroke.
|
14517540 |
2003 |
|
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
We evaluated nine PDE4D single nucleotide polymorphisms (SNPs) among 259 incident ischemic stroke cases and 259 controls were matched on age and smoking status and length of follow up since randomization, all drawn from initially healthy white males within the Physicians' Health Study cohort who were prospectively followed for first-ever stroke events.
|
16825591 |
2006 |
|
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
The identification of phosphodiesterase 4D gene as a risk factor for stroke caused a great deal of interest in stroke genetics.
|
19608201 |
2009 |
|
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
We selected and genotyped a PDE4D single nucleotide polymorphism (SNP 41, rs152312) as a candidate marker for susceptibility to ischemic stroke because SNP 41 has shown the most significant association with stroke in both a meta-analysis and the original Icelandic study of the PDE4D gene.
|
19399275 |
2009 |
|
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
There are several positive replication studies of PDE4D gene with stroke.
|
23135027 |
2013 |
|
Cerebrovascular accident
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Multivariate regression analysis showed that SNP87 of PDE4D gene was associated with increased risk of unfavorable outcome after total ischemic stroke (OR = 1.47, 95%CI 1.12-1.93), as well as stroke due to large-artery atherosclerosis (OR = 1.49, 95%CI 1.04-2.11) and small-artery occlusion (OR = 1.76, 95%CI 1.05-2.96) under a recessive model.
|
28225001 |
2017 |