ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall, the results of this study show that FAM49B acts as a suppressor of cancer cell proliferation and invasion in PDAC by regulating tumor mitochondrial redox reactions and metabolism.
|
29059164 |
2018 |
Bacterial Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection.
|
31285585 |
2019 |
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Cancer of Digestive System
|
0.010 |
Biomarker
|
disease |
BEFREE |
We also identified ZFR's potential transcriptional targets, and further investigations on those targets, especially FAM49B, will help us understand more about the important role of ZFR in digestive system cancers.
|
31010678 |
2019 |
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
When we knocked down the expression of FAM49B in CRC and liver cancer cells, we observed significantly accelerated cell proliferation, consistent with the results with ZFR overexpression.
|
31010678 |
2019 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
We also found six other DEGs/DEPs related to T2DM (CA1, Serpinb6a, AK, Pcolce, Cand2, and Atp2a3), and five related to cancer (Phgdh, Tes, Papss1, Psat1, and Fam49b).
|
31554135 |
2019 |
Heart Failure, Diastolic
|
0.300 |
Biomarker
|
disease |
CTD_human |
In Silico Analysis of Differential Gene Expression in Three Common Rat Models of Diastolic Dysfunction.
|
29556499 |
2018 |
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
Lymphocyte Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A two-stage validation revealed that plasma levels of three lncRNAs (FAM49B-AS, GUSBP11, and CTDHUT) were significantly higher in GC plasma as compared with healthy controls (P < 0.05), and the combined area under curve of these lncRNAs was 0.818 (95% CI 0.772-0.864).
|
30603909 |
2019 |
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Overall, the results of this study show that FAM49B acts as a suppressor of cancer cell proliferation and invasion in PDAC by regulating tumor mitochondrial redox reactions and metabolism.
|
29059164 |
2018 |
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
We also found six other DEGs/DEPs related to T2DM (CA1, Serpinb6a, AK, Pcolce, Cand2, and Atp2a3), and five related to cancer (Phgdh, Tes, Papss1, Psat1, and Fam49b).
|
31554135 |
2019 |
mathematical ability
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
|
30038396 |
2018 |
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis.
|
29059164 |
2018 |
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Overall, the results of this study show that FAM49B acts as a suppressor of cancer cell proliferation and invasion in PDAC by regulating tumor mitochondrial redox reactions and metabolism.
|
29059164 |
2018 |
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
FAM49B was a tumor suppressor candidate for ZFR targets.
|
31010678 |
2019 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder.
|
23726511 |
2013 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder.
|
23726511 |
2013 |
Primary malignant neoplasm
|
0.020 |
GeneticVariation
|
group |
BEFREE |
We also found six other DEGs/DEPs related to T2DM (CA1, Serpinb6a, AK, Pcolce, Cand2, and Atp2a3), and five related to cancer (Phgdh, Tes, Papss1, Psat1, and Fam49b).
|
31554135 |
2019 |
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Overall, the results of this study show that FAM49B acts as a suppressor of cancer cell proliferation and invasion in PDAC by regulating tumor mitochondrial redox reactions and metabolism.
|
29059164 |
2018 |
RDW - Red blood cell distribution width result
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Red cell distribution width determination
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Rheumatoid Arthritis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Studying the effects of haplotype partitioning methods on the RA-associated genomic results from the North American Rheumatoid Arthritis Consortium (NARAC) dataset.
|
30891314 |
2019 |
Salmonella infections
|
0.010 |
Biomarker
|
group |
BEFREE |
This revealed an uncharacterized role of CYRI (FAM49B) in conferring host resistance to Salmonella infection.
|
31285585 |
2019 |
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis.
|
29059164 |
2018 |