|
Astrocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Specific ACSL5-isoform transfection in HEK239T (kidney), U87 (astroglioma), and HOG (oligodendrocyte) cells showed the Spl protein to be the causal factor of cell-growth inhibition, despite its reduced protein expression.
|
31053784 |
2019 |
|
Congestive heart failure
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Usefulness of Rivaroxaban for Secondary Prevention of Acute Coronary Syndrome in Patients With History of Congestive Heart Failure (from the ATLAS-ACS-2 TIMI-51 Trial).
|
30340765 |
2018 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that ACSL1, ACSL4 and ACSL5 expression is regulated by ER signaling pathways and ACSL5 is a potential novel biomarker for predicting prognosis of breast cancer patients.
|
28498416 |
2017 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that ACSL1, ACSL4 and ACSL5 expression is regulated by ER signaling pathways and ACSL5 is a potential novel biomarker for predicting prognosis of breast cancer patients.
|
28498416 |
2017 |
|
Acute Chest Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Reasons for VAC application included confirmed ACS (2) and application to prevent ACS (13).
|
28099974 |
2017 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Enhanced cell growth and invasion ability mediated by the gain of ACS5 expression were associated with downregulation of caspase-3 and E-cadherin and upregulation of survivin and CD44.
|
28808653 |
2017 |
|
estrogen receptor-negative breast cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results further showed that high ACSL5 expression was associated with good prognosis in patients with both ER-positive and ER-negative breast cancer through KM plotter analysis.
|
28498416 |
2017 |
|
Obesity
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic studies on Acyl-CoA Synthetase Long-Chain 5 (ACSL5) demonstrate an association between rs2419621 genotype and rate of weight loss in women with obesity in response to caloric restriction.
|
27515448 |
2016 |
|
Migraine Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In conclusion, we identified the functional variant (rs2256368:A>G) affecting ACSL5 exon 20 skipping, as a causal factor linked to the migraine-associated rs12355831:A>G, suggesting that the activation of long-chain fatty acids by the spliced ACSL5-Δ20 molecules, a mitochondrial located enzyme, is involved in migraine pathology.
|
27189022 |
2016 |
|
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High expression of ACSL5 predicted good prognosis in breast, ovarian, and lung cancers.
|
27171439 |
2016 |
|
Overweight and obesity
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Women with overweight and obesity carrying the ACSL5 rs2419621 [T] allele are more responsive to lifestyle interventions in comparison to non-carriers.
|
27515448 |
2016 |
|
Carcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Anti-ACSL5 immunostainings showed expression in normal urothelium and a gradual loss of ACSL5 protein via pre-invasive lesions to invasive carcinomas.
|
23348389 |
2013 |
|
Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
This integrative proteomic and lipidomic study from mouse to human and from liver to blood identified the following disease signatures: (i) an HCC signature: upregulated hepatic scd1/scd2, fads2, and acsl5:acsl1 ratio, elevated vaccenic and erucic acids, and reduced margaric and linoleic acids in both liver and plasma; (ii) a NASH signature that correlates with tumor burden: upregulated hepatic elovl6, elevated oleic, adrenic, and osbond acids, and reduced cervonic acid in liver and plasma; and (iii) a NASH signature: reduced hepatic and circulating lignoceric and eicosapentaenoic acids.
|
23749645 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results point to ACSL5 as a potential novel functional marker of pathogenesis and a possible therapeutic target in SLE.
|
22163040 |
2011 |
|
Steatohepatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study gives evidence that hepatocyte steatosis is associated with ACSL5 up-regulation resulting in increased susceptibility to hepatic cell death.
|
20470896 |
2010 |
|
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The analysis revealed that ACSL5 was critical to the expression of tumor-related factors including midkine (MDK), a heparin-binding growth factor frequently overexpressed in cancer.
|
18806831 |
2009 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The analysis revealed that ACSL5 was critical to the expression of tumor-related factors including midkine (MDK), a heparin-binding growth factor frequently overexpressed in cancer.
|
18806831 |
2009 |
|
Hyperlipidemia
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Transcriptional activation of hepatic ACSL3 and ACSL5 by oncostatin m reduces hypertriglyceridemia through enhanced beta-oxidation.
|
17761945 |
2007 |
|
Celiac Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, ACS5 was found in the villus epithelium of the small intestine with coeliac disease of Marsh grades I, II, IIIa, or IIIb respectively.
|
15809837 |
2006 |
|
Anaplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
With regard to its value for histopathological diagnosis, immunohistochemical characterization of endometrioid adenocarcinomas shows that a decrease in ACS5 expression correlates with tumour dedifferentiation.
|
16241998 |
2005 |
|
Metaplasia
|
0.010 |
AlteredExpression
|
phenotype |
LHGDN |
Inversely, ACS5 expression could neither be detected in heterotopic gastric mucosa of the corpus type nor in gastric, pseudopyloric, or antral metaplasia of the small intestine.
|
15736044 |
2005 |
|
Intestinal metaplasia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Of note, strong expression of ACS5 was also detectable in intestinal metaplasia of the stomach.
|
15736044 |
2005 |
|
Adenocarcinoma, Endometrioid
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
With regard to its value for histopathological diagnosis, immunohistochemical characterization of endometrioid adenocarcinomas shows that a decrease in ACS5 expression correlates with tumour dedifferentiation.
|
16241998 |
2005 |
|
Postmenopausal endometrium
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, ACS5 expression was found throughout the menstrual cycle as well as in the postmenopausal endometrium.
|
16241998 |
2005 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results suggest the involvement of ACS5 in the early genesis of colorectal cancer, most likely by modification of the transport and pool formation of long-chain acyl-CoA thioesters, as recently demonstrated for other isoforms of the ACS family.
|
16110457 |
2005 |