|
Adenoid Cystic Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
The mutational landscape of adenoid cystic carcinoma.
|
23685749 |
2013 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
BCAA-enriched diet promoted the development of AD in mice as evidenced by the behavior and pathological analysis.
|
29802157 |
2018 |
|
Amino Acid Metabolism, Inborn Errors
|
0.020 |
Biomarker
|
group |
BEFREE |
Genetic disorders of BCAA metabolism produce amino acidopathies and various forms of organic aciduria with severe clinical consequences.
|
16365091 |
2006 |
|
Amino Acid Metabolism, Inborn Errors
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Maple syrup urine disease (MSUD) is an autosomal recessive aminoacidopathy secondary to an enzyme defect in the catabolic pathway of the branched-chain amino acids (BCAAs: leucine, isoleucine, and valine).
|
24486081 |
2016 |
|
ATRIAL SEPTAL DEFECT 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
ASD subjects were stratified into subpopulations based on shared metabolic phenotypes associated with BCAA dysregulation.
|
30446206 |
2019 |
|
Atrial Septal Defects
|
0.010 |
Biomarker
|
group |
BEFREE |
ASD subjects were stratified into subpopulations based on shared metabolic phenotypes associated with BCAA dysregulation.
|
30446206 |
2019 |
|
Autism Spectrum Disorders
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We identified groups of AAs with positive correlations that were, as a group, negatively correlated with BCAA levels in ASD.
|
30446206 |
2019 |
|
Brain Tumor, Primary
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, ARID4B is a satisfactory biomarker to highlight tumour component and predict tumour behaviour in primary brain neoplasms.
|
27451434 |
2017 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Computational analysis identified breast cancer progression gene Arid4b as a top target of miR-290-3p, which was confirmed by luciferase reporter assay.
|
23447578 |
2013 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Looking for novel breast cancer antigen epitopes is helpful for its treatment, diagnosis, and prevention. brcaa1 gene is mapped at 1q42.1-q43, its whole genome is 93.857 kb, including 18 exons and 17 introns.
|
15247124 |
2004 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
These studies support a causative role of ARID4B in metastatic progression of breast cancer.
|
22693453 |
2012 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Although ARID4B is known to promote tumour metastasis in breast cancer and inhibit transformation and progression in leukaemia, the possible effect of ARID4B on primary brain tumours (PBTs) is not well characterised.
|
27451434 |
2017 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
In this report, we used an immunoglobulin G (IgG) purified from serum of a patient with breast cancer to identify its corresponding epitope, gene, and protein-retinoblastoma-binding protein-1-like protein-1 (RBP1L1)-and determined whether it is a potential molecular marker for various cancers.
|
11481388 |
2001 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Functional analyses reveals that ARID4B is required for prostate tumorigenesis when PTEN is deficient.
|
31551414 |
2019 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
BCKDK of BCAA Catabolism Cross-talking With the MAPK Pathway Promotes Tumorigenesis of Colorectal Cancer.
|
28501528 |
2017 |
|
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis.
|
11481388 |
2001 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Adjusting for age, body mass index, and other established CVD risk factors, total BCAAs were positively associated with CVD (per SD: HR, 1.13; 95% CI, 1.08-1.18), comparable to LDL-C (low-density lipoprotein cholesterol) with CVD (per SD: HR, 1.12; 95% CI, 1.07-1.17).
|
29572205 |
2018 |
|
Chordoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Subsequently, immunohistochemical analysis of ARID4B was performed on 2 tissue microarrays, including 12 normal brain tissues, 63 meningiomas with different subtypes, 232 gliomas of various grades and degrees of differentiation, 8 central neurocytomas and 4 chordomas.
|
27451434 |
2017 |
|
Chronic kidney disease stage 5
|
0.010 |
Biomarker
|
disease |
BEFREE |
The studies indicate beneficial effects of BCAAs and BCKAs in therapy of chronic renal failure.
|
29755574 |
2018 |
|
Chronic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The studies indicate beneficial effects of BCAAs and BCKAs in therapy of chronic renal failure.
|
29755574 |
2018 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
BCKDK of BCAA Catabolism Cross-talking With the MAPK Pathway Promotes Tumorigenesis of Colorectal Cancer.
|
28501528 |
2017 |
|
Decrease in appetite
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
After timely BCAA-free nutrition and supplementation with thiamine for the patient, the plasma levels of BCAAs reached a safe level, the abnormal range of the multiple intracranial abnormalities was significantly smaller than before, and the symptoms of drowsiness and poor appetite disappeared.
|
31830945 |
2019 |
|
Depression, Postpartum
|
0.010 |
Biomarker
|
disease |
BEFREE |
We investigated whether perinatal consumption of a Western-type diet (high in fat and branched-chain amino acids [BCAA]) and associated gestational weight gain (GWG) cause serotonin dysregulation in the central nervous system (CNS), resulting in postpartum depression and anxiety (PPD/A).
|
29075574 |
2017 |
|
Diabetes
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our aims were to evaluate the relationship between BCAA and IR as well as later diabetes risk and explore the phenotypic and genetic factors influencing BCAA level based on available studies.
|
27642608 |
2016 |
|
Diabetes
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
BCAA levels were increased in the blood in human patients and mice with diabetes or AD.
|
29802157 |
2018 |