Glioma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies multiple susceptibility loci for glioma.
|
26424050 |
2015 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Subgroup analyses by ethnicity showed that RTEL1 rs6010620 polymorphism resulted in a higher risk of glioma among both Asians and Caucasians.
|
24523019 |
2014 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) at 7 loci influencing glioma risk: rs2736100 (TERT), rs11979158 and rs2252586 (EGFR), rs4295627 (CCDC26), rs4977756 (CDKN2A/CDKN2B), rs498872 (PHLDB1), and rs6010620 (RTEL1).
|
23161787 |
2013 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibility.
|
30714141 |
2019 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The current meta-analysis suggested that the rs6010620 polymorphism in the RTEL1 gene might increase risk of glioma.
|
25227808 |
2014 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility.
|
19578366 |
2009 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
And it might be used to evaluate the glioma development risks to screen the above RTEL1 tagging SNPs and haplotypes.
|
23683922 |
2013 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in or near RTEL1 and TERT, key components of telomere biology, are associated with glioma risk.
|
24231251 |
2013 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.
|
24908248 |
2014 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Statistical analyses on the association between RTEL1 single nucleotide polymorphisms (SNPs) and glioma risk were conducted using unconditional logistic regression.
|
30462709 |
2018 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk.
|
24908248 |
2014 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Three of the gene variants (rs4295627, a variant of CCDC26; rs4977756, a variant of CDKN2A and CDKN2B; and rs6010620, a variant of RTEL1) were statistically significantly associated with glioma risk in the present population.
|
21920947 |
2011 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, as previously shown for glioma regardless of family history of brain tumours, rs6010620 (RTEL1) was associated with an increased risk of glioma when restricting to cases with family history of brain tumours.
|
23115063 |
2013 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The A allele of rs6010620 in RTEL1 decreased the risk of developing glioma in the 12 case-control studies for all genetic models: the allele model (OR=0.752, 95%CI: 0.715-0.792), the dominant model (OR=0.729, 95%CI: 0.685-0.776), the recessive model (OR=0.647, 95%CI: 0.569-0.734), the homozygote comparison (OR=0.528, 95%CI: 0.456-0.612), and the heterozygote comparison (OR=0.761, 95%CI: 0.713-0.812).
|
25556444 |
2014 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies have implicated single nucleotide polymorphisms (SNPs) in 7 genes as glioma risk factors, including 2 (TERT, RTEL1) involved in telomerase structure/function.
|
23733245 |
2013 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)).
|
19578367 |
2009 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
Glioma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Thirteen well known genetic risk variants in TERT, EGFR, CCDC26, CDKN2A, CDKN2B, PHLDB1, TP53, and RTEL1 were selected for investigation of possible correlations with the glioma somatic markers: EGFR amplification, 1p/19q codeletion and protein expression of p53, Ki-67, and mutated IDH1.
|
26839018 |
2016 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of glioma and meta-analysis.
|
22886559 |
2012 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies have recently identified single-nucleotide polymorphisms (SNP) in five loci at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A/CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1) to be associated with glioma risk.
|
20847058 |
2010 |
Glioma
|
0.500 |
Biomarker
|
disease |
BEFREE |
The present study focuses on the impact of MPHOSPH6, TNIP1 and several other genes (ACYP2, NAF1, TERC, TERT, OBFC1, ZNF208 and RTEL1) on telomere length and how this affects the prognosis of glioma.
|
28985021 |
2017 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We confirmed the association with glioma risk for variants within five genomic regions: 8q24.21 (CCDC26), 9p21.3 (CDKN2B-AS1), 11q23.3 (PHLDB1), 17p13.1 (TP53), and 20q13.33 (RTEL1).
|
25713050 |
2015 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The pooled results indicated that the RTEL1 rs2297440 polymorphism moderately increased the risk of glioma in all genetic models.
|
26939676 |
2016 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Data from 855 high-grade glioma cases and 1,160 controls from 4 geographic regions of the United States during 1997-2008 were analyzed for interactions between allergy and smoking histories and inherited variants in 5 established glioma risk regions: 5p15.3 (TERT), 8q24.21 (CCDC26/MLZE), 9p21.3 (CDKN2B), 11q23.3 (PHLDB1/DDX6), and 20q13.3 (RTEL1).
|
21742680 |
2011 |
Glioma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of glioma and meta-analysis.
|
22886559 |
2012 |