Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, our results suggest that miR-93 might play an important role in glioma progression and uncover a novel mechanism for constitutive PI3K/Akt activation in gliomas.
|
25823655 |
2015 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The potential role of MAGI3 expression in PI3K/Akt signaling activation was further investigated by examining the correlation between MAGI3 expression and the expression of PI3K/Akt signaling downstream target genes in a glioma dataset using gene set enrichment analysis (GSEA).
|
26248734 |
2015 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
BRCA1-associated protein inhibits glioma cell proliferation and migration and glioma stem cell self-renewal via the TGF-β/PI3K/AKT/mTOR signalling pathway.
|
31776938 |
2020 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Genetic analyses demonstrated that EGFR and PI3K initiate malignant neoplastic transformation via a combinatorial genetic network composed primarily of other pathways commonly mutated or activated in human glioma, including the Tor, Myc, G1 Cyclins-Cdks, and Rb-E2F pathways.
|
19214224 |
2009 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, LINC00526/EZH2/AXL/PI3K/Akt/NF-κB form a feedback loop in glioma.
|
31240814 |
2019 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings present a novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis and that disruption of downstream CREB signaling attenuates tumor expansion.
|
29718345 |
2018 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings demonstrate that treatment with an ADP can suppress glioma cell migration and invasion via the PI3K/Akt/MMP-9 signaling pathway and provide a new platform for the development of drugs for treating glioma.
|
27686608 |
2016 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Bone marrow mesenchymal stem cells suppress growth and promote the apoptosis of glioma U251 cells through downregulation of the PI3K/AKT signaling pathway.
|
30784920 |
2019 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings shed new light on the miR-223/PAX6 pathway in glioma and this pathway might modulate the sensitivity of glioma to TMZ via regulating PI3K/Akt signaling pathway..
|
28332226 |
2017 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
CEP55 promotes cell proliferation and inhibits apoptosis via the PI3K/Akt/p21 signaling pathway in human glioma U251 cells.
|
29552118 |
2018 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Among the many possible mechanisms underlying its pathogenesis, hyperactivation of the PI3K/Akt pathway is essential to the occurrence and development of glioma through the loss of PTEN or somatic activating mutations in PIK3CA.
|
30542720 |
2019 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
AnnexinA5 promote glioma cell invasion and migration via the PI3K/Akt/NF-κB signaling pathway.
|
29520611 |
2018 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The inhibitory effect of miR-219-5p on MAPK and PI3K pathways and glioma cell migration could be rescued by the overexpression of wild type EGFR and vIII mutant of EGFR (both lacking 3'-UTR and thus being insensitive to miR-219-5p) suggesting that the inhibitory effects of miR-219-5p were indeed because of its ability to target EGFR.
|
23690991 |
2013 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the role of different PI3K isoforms in glioma is still largely unclear.
|
22079609 |
2012 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, the PI3K-mTOR inhibitor NVP-BEZ235, which is in clinical use, synergized with the lysosomotropic inhibitor of autophagy, chloroquine, another agent in clinical use, to induce apoptosis in glioma xenografts in vivo, providing a therapeutic approach potentially translatable to humans.
|
21062993 |
2010 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We now demonstrate that the phosphorylation of tyrosine-828 residue in CD133 C-terminal cytoplasmic domain mediates direct interaction between CD133 and phosphoinositide 3-kinase (PI3K) 85 kDa regulatory subunit (p85), resulting in preferential activation of PI3K/protein kinase B (Akt) pathway in glioma stem cell (GSC) relative to matched nonstem cell.
|
23569237 |
2013 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the present study, KEGG PathwayFinder by gene correlation analysis was performed on the R2: Genomics Analysis and Visualization Platform, which revealed a high association between Ngb and the phosphatidylinositol 3‑kinase (PI3K)/AKT pathway using glioma data (GSE4290) from the Gene Expression Omnibus database.
|
29207186 |
2018 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Sevoflurane downregulates insulin-like growth factor-1 to inhibit cell proliferation, invasion and trigger apoptosis in glioma through the PI3K/AKT signaling pathway.
|
31305291 |
2019 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our results suggest that LASP1 activates the PI3K/AKT signaling pathway and is downregulated by miR-377-3p during glioma progression.
|
30372896 |
2018 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We demonstrate that the PTEN-PI3K axis regulates HIF1α in glioma models.
|
24162827 |
2014 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This RTK/PTEN/PI3K pathway leads to activated AKT and phospho-AKT levels are elevated in the majority of GBM tumor samples and cell lines, which studies show help glioma cells grow uncontrolled, evade apoptosis, and enhance tumor invasion.
|
21827416 |
2011 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
DANCR promotes cisplatin resistance via activating AXL/PI3K/Akt/NF-κB signaling pathway in glioma.
|
29572052 |
2018 |
Glioma
|
0.400 |
CausalMutation
|
disease |
CGI |
|
|
|
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Similar to PI3K, NF-κB is associated with the regulation of BMSCs migration toward glioma.
|
26034878 |
2015 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest that Liq treatment enhances glioma cell susceptibility to TMZ by inhibiting the PI3K/AKT/mTOR pathway.
|
25351348 |
2015 |