Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Strategies targeting PI3K signal transduction or the association of PI3K with Rb, or regulating PI3K-Rb interactions could be employed for gene therapy or chemotherapy of gastric cancer and other tumors.
|
15809724 |
2005 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cooperation between RUNX3 and the PI3K/Akt signaling pathway component FoxO3a/FKHRL1 suggests the putative role of RUNX3 in the homoeostasis of gastric cells and in stomach cancer control.
|
16627973 |
2006 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our results suggest that PrP(C)-induced MDR in gastric cancer is associated with activation of the PI3K/Akt pathway.
|
19143835 |
2009 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Up-regulation of PIK3CA may promote the metastasis of gastric cancer through aberrant activation of PI3K/Akt signaling.
|
20954287 |
2010 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results show that MSI gastric carcinoma frequently shows activation of EGFR-MAPK and PI3K pathways.
|
20937558 |
2011 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To define the inhibitory and pro-apoptotic effects of the two PI3K inhibitors BEZ235 and BKM120 in three human colon cancer (HT-29, HCT-116 and DLD-1) and three gastric cancer (NCI-n87, AGS and MKN-45), cell lines with different PIK3CA gene mutation status were used.
|
22543857 |
2012 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PIK3R3, the gene that encodes the PI3K regulatory subunit p55γ, is over-expressed in glioblastoma and ovarian cancers, but its expression in gastric cancer (GC) is not known.
|
22876838 |
2012 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of ZIC1 results in inactivation of Shh, PI(3)K and MAPK signaling pathways, as well as regulation of multiple downstream targets which are essential for the development and progression of gastric cancer.
|
22799764 |
2012 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
PI3K/AKT pathway may represent an important therapeutic target for gastric cancer.
|
23058013 |
2012 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, the PI3K/Akt signaling pathway may be an effective therapeutic target in gastric cancer.
|
22292935 |
2012 |
Stomach Carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
These results show that H. pylori infection induces AKT/PI3K-mediated phosphorylation of p27 at T157 and T198 to cause cytoplasmic p27 mislocalization in gastric cancer, and that p27 mislocalization is an adverse prognostic feature in gastric cancer.
|
21841827 |
2012 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus far, the human epidermal growth factor receptor (HER) pathway, angiogenic pathway, and phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target of rapamycin pathway have emerged as potential avenues for targeted therapy in AGC patients.
|
22334453 |
2012 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Notch2 may negatively regulate cell invasion by inhibiting the PI3K-Akt signaling pathway in gastric cancer.
|
23326131 |
2012 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have investigated the frequency of molecular changes in the PI3K pathway in gastric cancer.
|
23813545 |
2013 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggested that the PI3K/Akt inhibitor LY294002 can enhance chemosensitivity of human gastric cancer to VCR.
|
23743572 |
2013 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study was designed to test whether semaphorin 5A mediates the invasion and metastasis of gastric cancer via PI3K/Akt/uPA signaling.
|
23661031 |
2013 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PPP1R1B-STARD3 chimeric fusion transcript in human gastric cancer promotes tumorigenesis through activation of PI3K/AKT signaling.
|
24276243 |
2014 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The effects of miR-34a ectopic expression on the AKT and p-AKT expression of cisplatin-induce gastric cancer cells were determined by Western blot and flow cytometry with the PI3K pathway inhibitor Wortmannin.
|
24068565 |
2014 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hence, it is necessary to clarify not only HER2 alterations but also PI3K-Akt pathway alterations for HER2-targeting therapy in GC.
|
24458107 |
2014 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study consolidates knowledge on the frequency, co-occurrence and clinical relevance of PI3K pathway aberrations in GC and CRC.
|
23960014 |
2014 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MiR-19a promotes epithelial-mesenchymal transition through PI3K/AKT pathway in gastric cancer.
|
25400827 |
2014 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest that EGF-induced activation of MMP7 and MMP13 in GC is through phosphatidylinositol 3-kinase (PI3K) and extracellular-related kinase/mitogen-activated protein kinase (ERK/MAPK) signaling pathway, respectively.
|
25085584 |
2014 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, this CagA- PI3K/AKT-Sp1-RBP2-Cyclin D1 pathway may serve as a novel mechanism for gastric epithelial cell malignant transformation and then gastric cancer (GC).
|
25015565 |
2014 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, miR-34a may act as a potential tumour suppressor in gastric cancer and is associated with the mechanisms of gastric cancer metastasis; miR-34a can inhibit gastric cancer tumourigenesis by targeting PDGFR and MET through the PI3K (phosphoinositide 3-kinase)/Akt pathway.
|
24837198 |
2014 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cooperative relationships were identified between PI3K and Akt, and PI3K and survivin (P<0.01), suggesting the involvement of the PI3K/Akt/survivin signaling pathway in the tumorigenesis of gastric cancer.
|
24726064 |
2014 |