|
Hemangioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, knockdown of ID-1 suppressed proliferation and promoted apoptosis by inactivating phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR signaling in HDECs, shedding light on the function of ID-1 in HA progression and highlighting the therapeutic value of ID-1 for HA.
|
30584986 |
2019 |
|
Keratitis, Herpetic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Modulation of Corneal FAK/PI3K/Akt Signaling Expression and of Metalloproteinase-2 and Metalloproteinase-9 during the Development of Herpes Simplex Keratitis.
|
31061823 |
2019 |
|
Hydrocephalus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using the same, highly regulatable brain-specific model, here we report PI3K-dependent mechanisms underlying gyrification of the normally smooth mouse cortex, and hydrocephalus.
|
31094678 |
2019 |
|
Irritable Bowel Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A.
|
31272268 |
2019 |
|
Keloid
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings together demonstrate a tumor-suppressive role of miR-188-5p in KD proliferation and invasion via PI3K/Akt/MMP-2/9 signaling, indicating that miR-188-5p may be a potential prognostic marker and therapeutic target for KDs.
|
30668826 |
2019 |
|
Ketosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Dairy cows with fatty liver or ketosis display decreased insulin sensitivity and defects in the insulin receptor substrate (IRS)/PI3K/AKT signaling pathway.
|
30819264 |
2019 |
|
Kidney Calculi
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Taken together, we conclude that GRPR gene silencing suppresses the development of the EMT and formation of the calcium oxalate crystal in renal TECs of kidney stones through the inactivation of the PI3K/Akt signaling pathway.
|
30144073 |
2019 |
|
Meningitis, Pneumococcal
|
0.010 |
Biomarker
|
disease |
BEFREE |
Diosmetin Suppresses Neuronal Apoptosis and Inflammation by Modulating the Phosphoinositide 3-Kinase (PI3K)/AKT/Nuclear Factor-κB (NF-κB) Signaling Pathway in a Rat Model of Pneumococcal Meningitis.
|
30914630 |
2019 |
|
Metabolic Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Thus, CBAP represents a novel therapeutic target for many types of cancers and metabolic diseases linked to PI3K-Akt-mTORC1 signaling.
|
30266989 |
2019 |
|
Neuromuscular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
We demonstrate that the PI3K/Akt pathway is essential for the full myogenic effect of AVP and that, by targeting this pathway, one may highlight novel strategies to counteract muscle wasting in aging or neuromuscular disorders.
|
31461843 |
2019 |
|
Neuromyelitis Optica
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study showed that the Tie2-PI3K/Akt, Tie2 integrin, and integrin-PI3K/Akt signaling pathways regulate C16 peptide function in vascular growth and stabilization as well as inflammation in NMO.
|
31849648 |
2019 |
|
oligodendroglioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We additionally implanted 13 tumors to investigate the relationship between PI3K/AKT/mTOR pathway alterations and oligodendroglioma xenograft formation.
|
30975663 |
2019 |
|
Pain, Postoperative
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The aim of this study was to clarify whether post-surgical inhibition of PI3K would attenuate the POP and the underlying mechanisms.
|
31366324 |
2019 |
|
Plasma cell mastitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Exosomes Play an Important Role in the Progression of Plasma Cell Mastitis via the PI3K-Akt-mTOR Signaling Pathway.
|
31281227 |
2019 |
|
Prader-Willi Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this review, we summarize current knowledge on the etiology and pathology of PWS/SWS based on evidence that the activation of MAPK and/or PI3K contributes to the malformations, as well as potential futuristic treatment approaches targeting these aberrantly dysregulated signaling pathways.
|
31067686 |
2019 |
|
Pterygium
|
0.010 |
Biomarker
|
disease |
BEFREE |
The microRNA-218-5p-EGFR-PI3K/Akt/mTOR axis should be further investigated for the potential treatment of pterygium.
|
30243568 |
2019 |
|
Rabies (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
LaSota Strain Expressing The Rabies Virus Glycoprotein (rL-RVG) Suppresses Gastric Cancer by Inhibiting the Alpha 7 Nicotinic Acetylcholine Receptor (α7 nAChR)/Phosphoinositide 3-Kinase (PI3K)/AKT Pathway.
|
31337746 |
2019 |
|
Respiratory Tract Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
The subsequent irregular PI3K downstream signaling cascade is associated with abnormalities in B cells and T cells and the consequent heterogeneous clinical manifestations including respiratory tract infections, autoimmunity, lymphoproliferation and not to mention primary antibody deficiency.
|
30799802 |
2019 |
|
Sezary Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
The PI3K/AKT/mTOR pathway is hyperactivated in many tumors, as well as in cutaneous T-cell lymphoma (CTCL) which includes mycosis fungoides (MF) and the aggressive variant known as Sezary syndrome (SS).
|
31682844 |
2019 |
|
Sturge-Weber Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this review, we summarize current knowledge on the etiology and pathology of PWS/SWS based on evidence that the activation of MAPK and/or PI3K contributes to the malformations, as well as potential futuristic treatment approaches targeting these aberrantly dysregulated signaling pathways.
|
31067686 |
2019 |
|
Synovitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Intraperitoneal injection of PI3K inhibitor LY294002 could decrease the Cadherin-11 protein expression in synovium of CIOA mice, although it has no significant inhibitory effect on synovitis and cartilage damage.
|
31829201 |
2019 |
|
Thromboangiitis Obliterans
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The low expression of bradykinin can promote TAO in rats by the mechanism that it inhibits the PI3K/Akt signaling pathway to raise the oxidative stress level, thereby aggravating TAO.
|
31799689 |
2019 |
|
Vomiting
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, our behavioral findings demonstrated that the following agents suppressed vomiting evoked by GR73632 in a dose-dependent manner: i) the NK<sub>1</sub>R antagonist netupitant (i.p.); ii) the L-type Ca<sup>2+</sup> channel (LTCC) antagonist nifedipine (subcutaneous, s.c.); iii) the inositol trisphosphate receptor (IP<sub>3</sub>R) antagonist 2-APB (i.p.); iv) store-operated Ca<sup>2+</sup> entry inhibitors YM-58483 and MRS-1845, (i.p.); v) the ERK1/2 pathway inhibitor U0126 (i.p.); vi) the PKC inhibitor GF109203X (i.p.); and vii) the inhibitor of phosphatidylinositol 3-kinase (PI3K)-Akt pathway LY294002 (i.p.).
|
30453005 |
2019 |
|
Ventricular arrhythmia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we aimed to explore whether targeted regulation of sympathetic activity in PVN could reduce the peripheral sympathoexcitatory and attenuate the ventricular arrhythmias (VAs) in myocardial infarction (MI) rats via PI3K-AKT pathway.
|
30487059 |
2019 |
|
Obstructive nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Tamoxifen ameliorates obstructive nephropathy through Src and the PI3K/Akt/mTOR pathway.
|
30304547 |
2019 |