|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Stably overexpressing Pim-1 kinase cell lines were characterized for their response to IL-6 in vitro and for their growth rate as flank tumors in scid mice.
|
22273698 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Provirus insertion near c-myc, pim-1 or Mlvi-1 occurred both in diploid lymphomas and in tumors with trisomy 15.
|
3021636 |
1986 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It is well known that provirus integration site for Moloney murine leukemia virus 1 (Pim-1) plays an essential role in the occurrence and development of tumors.
|
20544717 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It is not clear whether Pim-1 is involved in hypoxia-mediated tumor survival in solid tumors.
|
19528349 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
By analogy with other cellular oncogenes that are similarly activated (e.g., myc, myb, erbB) it is possible that pim-1 may also be involved in some human tumors.
|
3475233 |
1987 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In summary, we revealed that miR-638 functions as a tumor suppressor through inhibiting PIM1 expression in OS.
|
28050866 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, more and more studies including ours have found that PIM1 can induce senescence in normal human diploid fibroblasts and behave as a tumor suppressor.
|
29763603 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our results suggest that TTP post-transcriptionally down-regulates Pim-1 expression and that the overexpression of TTP may contribute to tumor suppression in part by down-regulating Pim-1 expression.
|
22700982 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
There is also a correlation with markers of cancer stem cells, which may contribute to the therapy resistance found in tumors overexpressing PIM kinases.
|
27901106 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Several lines of evidence have indicated that dysregulation of Pim-1 can interfere with the cell cycle and apoptosis to promote malignant transformation of a number of types of tumour.
|
24737044 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis.
|
19147983 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Taken together, PIM1 is up-regulated by hypoxia in HCC and promotes tumor growth and metastasis through facilitating cancer cell glycolysis.
|
25834102 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Pim-1 immunoreactivity is higher in the more differentiated components of a tumour.
|
16546353 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Using knockdown studies, we showed that PIM1 contributes to melanoma cell proliferation and tumor growth in vivo; however, the presence of PIM2 and PIM3 could also influence the outcome.
|
27448973 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The relationship between c-Myb and the serine-threonine kinase pim-1, its immediate activator, is discussed, together with the possibility that c-Myb, like pim-1, may be able to synergize with c-Myc to induce tumors.
|
10378698 |
1999 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The constitutively active serine/threonine kinase proviral integration site for moloney murine leukemia virus 1 (PIM1) was recently found to be overexpressed in GB patient samples and to maintain cell survival in these tumors.
|
30389373 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Conditional transgenic expression of PIM1 kinase in prostate induces inflammation-dependent neoplasia.
|
23565217 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Pim-1 expression in the tumor (median 0.28) was significantly down-regulated (p<0.0001) compared to the paired normal tissue (median 4.96).
|
18695914 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Accordingly, pharmacological inhibition of c-Abl together with Aurora resulted in substantial cell death and tumor regression <i>in vivo</i> The findings reveal an important functional interaction between NIK, Abl and Aurora kinases, and identify the NIK, c-Abl and PIM survival kinases as potential pharmacological targets for improving the efficacy of Aurora inhibitors in myeloma.
|
30948493 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Pim-1 inhibitor SMI-4a suppresses tumor growth in non-small cell lung cancer via PI3K/AKT/mTOR pathway.
|
31114247 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Transgenic animals carrying human c-Ha-ras proto-oncogene, v-Ha-ras transgenic mice, pim-1 transgenic mice and several knockout mice deficient of tumor suppressor genes, such as p53, have been shown to exhibit increased carcinogen susceptibility.
|
15958052 |
2005 |