|
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Herein, circ-PITX1 was found to be upregulated in glioblastoma and could mediate glioblastoma tissues and cell lines.
|
31493405 |
2019 |
|
Congestive heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Abbreviations:</b> ART: anti-retroviral therapy; Child PIP: Child Healthcare Problem Identification Programme; CCF: congestive cardiac failure; CNS: central nervous system; CoNS: coagulase-negative <i>staphylococci</i>; CSF: cerebrospinal fluid; DNA pcr: deoxyribonucleic acid polymerase chain reaction; ETAT: emergency triage assessment and treatment; LMIC: low- and middle-income countries; MDG: Millennium Development Goals; MRI: magnetic resonance imaging; MRSA: methicillin-resistant <i>Staphylococcus aureus</i>; NAI: non-accidental injury; NTS: non-typhi salmonella; PJP: <i>Pneumocystis jiroveci</i> pneumonia; PSHD: presumed severe HIV disease; QECH: Queen Elizabeth Central Hospital; RHD: rheumatic heart disease; RTA: road traffic accident; TB: tuberculosis; TBM: tuberculous meningitis; WHO: World Health Organization; SAM: severe acute malnutrition.
|
30451103 |
2019 |
|
Congenital emphysema
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PITX1 expression was increased in CLE lesions based on immunohistochemistry, and by using small interfering RNA knockdown, we illustrated that <i>PITX1</i> was required for upregulation of IFN-regulated genes in vitro.
|
30745462 |
2019 |
|
Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Herein, circ-PITX1 was found to be upregulated in glioblastoma and could mediate glioblastoma tissues and cell lines.
|
31493405 |
2019 |
|
Childhood Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Herein, circ-PITX1 was found to be upregulated in glioblastoma and could mediate glioblastoma tissues and cell lines.
|
31493405 |
2019 |
|
Glioblastoma Multiforme
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Herein, circ-PITX1 was found to be upregulated in glioblastoma and could mediate glioblastoma tissues and cell lines.
|
31493405 |
2019 |
|
Childhood Ataxia with Central Nervous System Hypomyelinization
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PITX1 expression was increased in CLE lesions based on immunohistochemistry, and by using small interfering RNA knockdown, we illustrated that <i>PITX1</i> was required for upregulation of IFN-regulated genes in vitro.
|
30745462 |
2019 |
|
Somatotrophinoma, Familial
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
At a median follow-up of 36.7 (range 1-84) months, the CCF-FIS significantly improved from a preoperative baseline of 15.9 ± 2.98 to 5.2 ± 3.92 (95%CI: 15.46 vs 4.43; p < 0.0001).
|
31190233 |
2019 |
|
Malignant tumor of colon
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The PITX1 genetic variant showed significant interactions with regular exercise and CRC risk (p-interaction = 0.018) and colon cancer risk (p-interaction = 0.029) among all subjects.
|
29484135 |
2018 |
|
Membranous glomerulonephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Together, our results suggest that in injured tissue, decreased PITX1 expression at the MTNR1A promoter regions leads to decreased levels of MTNR1A in renal tubular epithelial cells, which increases the future risk of MN.
|
29480949 |
2018 |
|
Incontinence
|
0.010 |
Biomarker
|
disease |
BEFREE |
All three studies reported positive outcomes, with CCF scores and incontinence episodes improving significantly.
|
29086238 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PITX1 expression increased in male patients, advanced TNM stage, advanced T stage and advanced regional lymph node status of LUAD patients.
|
30322808 |
2018 |
|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we designed HP55/poly( n-butylcyanoacrylate) (PBCA) nanoparticles (NPs) to carry Helicobacter pylori ( H. pylori) subunit vaccine CCF for oral administration in a prophylactic mice model.
|
30011213 |
2018 |
|
Adolescent idiopathic scoliosis
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Abnormal PITX1 gene methylation in adolescent idiopathic scoliosis: a pilot study.
|
29743058 |
2018 |
|
Colon Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The PITX1 genetic variant showed significant interactions with regular exercise and CRC risk (p-interaction = 0.018) and colon cancer risk (p-interaction = 0.029) among all subjects.
|
29484135 |
2018 |
|
Papillary serous endometrial carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We compared metabolic profiles and reactions to paclitaxel in both a wild type USC cell line (USPC-1) and PTX-1, a cell line derived from USPC-1 which acquired paclitaxel resistance, using a capillary electrophoresis CE-MS/MS system.
|
30174791 |
2018 |
|
ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
Both PITX1 exon 3 and lincRNA C5orf66-AS1 were significantly higher methylated in tumor tissue than in normal adjacent tissue (NAT) (PITX1 exon 3: tumor tissue 58.1%, NAT: 31.7%, p<0.001; lincRNA C5orf66-AS1: tumor tissue: 27.4%, NAT: 18.9%, p<0.001).
|
29425237 |
2018 |
|
Aortic Valve Stenosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Each BAV was classified using both dichotomous (right and left coronary cusp fusion [CCF] vs mixed cusp fusion [MCF]) and conventional methods, and its association with the dominant valvulopathy (aortic stenosis [AS] vs regurgitation) and concomitant aortic surgery was analyzed.
|
29066082 |
2017 |
|
Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The RCC cell lines Caki-1 and CCF-RC1, which highly express integrin α5, were treated with fibronectin in combination with or without an inhibiting anti-integrin α5 antibody.
|
29296184 |
2017 |
|
Gastritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, a mass of T-cells were observed in the lamina propria of mice immunized with CCF, especially in the HP55/PLGA-CCF nanoparticles administered recipients, and contributed to the development of postimmunization gastritis.
|
27865932 |
2017 |
|
Heart valve disease
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Each BAV was classified using both dichotomous (right and left coronary cusp fusion [CCF] vs mixed cusp fusion [MCF]) and conventional methods, and its association with the dominant valvulopathy (aortic stenosis [AS] vs regurgitation) and concomitant aortic surgery was analyzed.
|
29066082 |
2017 |
|
Nodule
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, we show that ectopic expression of Pitx1 in the forelimb is sufficient to generate nodule patterns characteristic of the hindlimb.
|
28746404 |
2017 |
|
Bicuspid aortic valve
|
0.010 |
Biomarker
|
disease |
BEFREE |
Each BAV was classified using both dichotomous (right and left coronary cusp fusion [CCF] vs mixed cusp fusion [MCF]) and conventional methods, and its association with the dominant valvulopathy (aortic stenosis [AS] vs regurgitation) and concomitant aortic surgery was analyzed.
|
29066082 |
2017 |
|
Metastatic Renal Cell Cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of the current study was to validate the associations of both SNPs with sunitinib outcome in three independent well-characterized cohorts (SUTOX, CCF and SOGUG) including 286 sunitinib-treated mRCC patients, as well as to perform a meta-analysis of current and published data combined.
|
27901483 |
2017 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
A PITX1-transfected ESCC cell line, KYSE30, formed smaller tumors in nude mice than in mock-transfected cells.
|
29137437 |
2017 |