PLA2G5, phospholipase A2 group V, 5322

N. diseases: 29; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0850572
Disease: Adenomatous polyp of colon
Adenomatous polyp of colon 		0.010 Biomarker disease BEFREE DNA sequence analysis demonstrated that alterations of PLA2G2A, as well as related genes PLA2G2C and PLA2G5, were evenly distributed between three classes of AAPC subjects: those with small, intermediate, and large numbers of adenomatous colonic polyps. 8640784 1996
CUI: C0201657
Disease: C-reactive protein measurement
C-reactive protein measurement 		0.100 GeneticVariation phenotype GWASCAT Group IIA Secretory Phospholipase A2, Vascular Inflammation, and Incident Cardiovascular Disease. 31070471 2019
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.010 AlteredExpression phenotype BEFREE A calcium-dependent phospholipase A2 (cPLA2) expression is regulated by MIG-6 during endometrial tumorigenesis. 30773264 2019
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.010 AlteredExpression disease BEFREE Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels. 24563418 2014
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.020 GeneticVariation disease BEFREE Our results demonstrate the association of the PLA2G5 rs11573191 polymorphism with premature CAD. 24959594 2014
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.020 AlteredExpression disease BEFREE Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels. 24563418 2014
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.010 GeneticVariation disease BEFREE This novel approach for single-nucleotide polymorphism selection for this modified Mendelian randomization analysis showed no association between rs525380 (the lead single-nucleotide polymorphism for PLA2G5 expression, a surrogate for sPLA2-V levels) and CHD events. 24563418 2014
CUI: C0015397
Disease: Disorder of eye
Disorder of eye 		0.300 Biomarker group GENOMICS_ENGLAND
CUI: C0015397
Disease: Disorder of eye
Disorder of eye 		0.300 Biomarker group GENOMICS_ENGLAND
CUI: C0015397
Disease: Disorder of eye
Disorder of eye 		0.300 Biomarker group GENOMICS_ENGLAND
CUI: C0014457
Disease: Eosinophilia
Eosinophilia 		0.010 Biomarker disease BEFREE Unexpectedly, while adoptive transfer of bone marrow-derived (BM)-macrophages restored ILC2 activation and eosinophilia in Alternaria-exposed Pla2g5-null mice, exogenous IL-33 did not. 29346348 2018
CUI: C1306759
Disease: Eosinophilic disorder
Eosinophilic disorder 		0.010 Biomarker group BEFREE Unexpectedly, while adoptive transfer of bone marrow-derived (BM)-macrophages restored ILC2 activation and eosinophilia in Alternaria-exposed Pla2g5-null mice, exogenous IL-33 did not. 29346348 2018
CUI: C0016059
Disease: Fibrosis
Fibrosis 		0.010 AlteredExpression phenotype LHGDN Distribution of type V secretory phospholipase A2 expression in human hepatocytes damaged by liver disease. 15377291 2004
CUI: C1856718
Disease: Fleck Retina, Familial Benign
Fleck Retina, Familial Benign 		0.700 GermlineCausalMutation disease ORPHANET Biallelic mutations in PLA2G5, encoding group V phospholipase A2, cause benign fleck retina. 22137173 2011
CUI: C1856718
Disease: Fleck Retina, Familial Benign
Fleck Retina, Familial Benign 		0.700 GeneticVariation disease CLINVAR
CUI: C1856718
Disease: Fleck Retina, Familial Benign
Fleck Retina, Familial Benign 		0.700 Biomarker disease CTD_human
CUI: C1856718
Disease: Fleck Retina, Familial Benign
Fleck Retina, Familial Benign 		0.700 GeneticVariation disease UNIPROT Biallelic mutations in PLA2G5, encoding group V phospholipase A2, cause benign fleck retina. 22137173 2011
CUI: C1856718
Disease: Fleck Retina, Familial Benign
Fleck Retina, Familial Benign 		0.700 Biomarker disease GENOMICS_ENGLAND
CUI: C0017638
Disease: Glioma
Glioma 		0.010 AlteredExpression disease BEFREE The immunohistochemistry of the 82 glioma tissues further confirmed that PLA2G5 protein expression was dependent on the WHO glioma grade. 31114356 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.010 GeneticVariation group BEFREE PLA2G5 polymorphisms were in linkage disequilibrium and the CGA haplotype was associated with increased risk of premature CAD (OR = 1.49, P = 0.0023) and with hypertension in these patients (OR = 1.75, P = 0.0072). 24959594 2014
CUI: C3714514
Disease: Infection
Infection 		0.020 AlteredExpression group LHGDN Distribution of type V secretory phospholipase A2 expression in human hepatocytes damaged by liver disease. 15377291 2004
CUI: C3714514
Disease: Infection
Infection 		0.020 Biomarker group LHGDN Group V and X secretory phospholipase A2 prevents adenoviral infection in mammalian cells. 16146426 2006
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.100 GeneticVariation disease GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
CUI: C0023895
Disease: Liver diseases
Liver diseases 		0.010 Biomarker group LHGDN Distribution of type V secretory phospholipase A2 expression in human hepatocytes damaged by liver disease. 15377291 2004
CUI: C0202117
Disease: Low density lipoprotein cholesterol measurement
Low density lipoprotein cholesterol measurement 		0.100 GeneticVariation phenotype GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012