PLAT, plasminogen activator, tissue type, 5327

N. diseases: 392; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0000737
Disease: Abdominal Pain
Abdominal Pain
0.010 Biomarker phenotype BEFREE This case highlights the need to consider a rectus sheath hematoma as a differential diagnosis of abdominal pain following treatment with recombinant tissue-type plasminogen activator. 30122629 2018
CUI: C0001125
Disease: Acidosis, Lactic
Acidosis, Lactic
0.300 Therapeutic phenotype CTD_human Airway tissue plasminogen activator prevents acute mortality due to lethal sulfur mustard inhalation. 25331496 2015
CUI: C0600433
Disease: Activated Protein C Resistance
Activated Protein C Resistance
0.010 GeneticVariation disease BEFREE Over a 36-month period, 46 consecutive Mexican mestizos with a clinical marker associated with a primary hypercoagulable state were prospectively assessed by searching for the sticky platelet syndrome (SPS), the activated protein C resistance (aPCR) phenotype, coagulation protein C activity and antigen, coagulation protein S, antithrombin III, plasminogen, tissue-type plasminogen activator activity, plasminogen activator inhibitor activity, plasminogen activator inhibitor type 1, IgG and IgM isotypes of antiphospholipid antibodies, homocysteine levels, the factor V gene Leiden, Cambridge, Hong Kong, and Liverpool mutations, the 677 C-->T mutation in the 5,10-methylenetetrahydrofolatereductase (MTHFR), and the G20210A polymorphism in the 3'-untranslated region of the prothrombin gene. 15609280 2005
CUI: C0241868
Disease: acute aortic dissection
acute aortic dissection
0.010 Biomarker disease BEFREE Thus, the concurrent acute aortic dissection is the contraindication for the intravenous recombinant tissue-type plasminogen activator. 29525082 2018
CUI: C2215101
Disease: Acute cerebral ischemia
Acute cerebral ischemia
0.010 Biomarker disease BEFREE Norwegian Tenecteplase Stroke Trial was a phase-3 trial investigating safety and efficacy of tenecteplase vs. alteplase in patients with suspected acute cerebral ischemia. 30019629 2019
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.360 Therapeutic disease CTD_human """Telestroke"" : the application of telemedicine for stroke." 9933289 1999
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.360 Biomarker disease CTD_human Tissue plasminogen activator for acute ischemic stroke. 7477192 1995
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.360 Therapeutic disease CTD_human Dosing errors may impact the risk of rt-PA for stroke: the Multicenter rt-PA Acute Stroke Survey. 17903947 2007
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.360 Biomarker disease CTD_human tPA-associated reperfusion after acute stroke demonstrated by SPECT. 9472885 1998
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.360 Therapeutic disease CTD_human Intravenous thrombolysis for acute ischemic stroke: the phase IV data. 17903870 2007
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.360 Therapeutic disease CTD_human A systems approach to immediate evaluation and management of hyperacute stroke. Experience at eight centers and implications for community practice and patient care. The National Institute of Neurological Disorders and Stroke (NINDS) rt-PA Stroke Study Group. 9259745 1997
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.360 Therapeutic disease CTD_human Variables associated with hospital arrival time after stroke: effect of delay on the clinical efficiency of early treatment. 9056608 1997
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.360 Biomarker disease CTD_human Admission glucose level and clinical outcomes in the NINDS rt-PA Stroke Trial. 12221155 2002
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.360 Biomarker disease CTD_human """Telestroke"" : the application of telemedicine for stroke." 9933289 1999
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.360 Biomarker disease CTD_human A method to determine stroke trial success using multidimensional pooled control functions. 19286598 2009
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.360 Biomarker disease BEFREE Patients received alteplase up to 9 hours after the onset or on awakening based on automated perfusion imaging. sICH was ascertained using ECASS II (The Second European-Australasian Acute Stroke Study) criteria. 31394994 2019
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.360 Biomarker disease CTD_human Lack of association between hyperglycaemia at arrival and clinical outcomes in acute stroke patients treated with tissue plasminogen activator. 20536612 2010
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.360 Therapeutic disease CTD_human Nursing management of acute complications following rt-PA in acute ischemic stroke. The NINDS rt-PA Stroke Study Group. 9479658 1997
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.360 Biomarker disease CTD_human An open, multicenter trial of recombinant tissue plasminogen activator in acute stroke. A progress report. The rt-PA Acute Stroke Study Group. 2124386 1990
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.360 Therapeutic disease CTD_human Admission glucose level and clinical outcomes in the NINDS rt-PA Stroke Trial. 12221155 2002
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.360 Biomarker disease CTD_human Code Stroke: rapid transport, triage and treatment using rt-PA therapy. The NINDS rt-PA Stroke Study Group. 9479657 1997
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.360 Biomarker disease CTD_human An overview of the patency and stroke rates following thrombolysis with streptokinase, alteplase, and anistreplase used to treat an acute myocardial infarction. 10171637 1993
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.360 Biomarker disease CTD_human Symptomatic intracerebral hemorrhage among eligible warfarin-treated patients receiving intravenous tissue plasminogen activator for acute ischemic stroke. 20212195 2010
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.360 Therapeutic disease CTD_human An open, multicenter trial of recombinant tissue plasminogen activator in acute stroke. A progress report. The rt-PA Acute Stroke Study Group. 2124386 1990
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents
0.360 Therapeutic disease CTD_human In acute ischemic stroke, are asymptomatic intracranial hemorrhages clinically innocuous? 15087567 2004