|
Malignant neoplasm of esophagus
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
A single-nucleotide polymorphism (rs2274223: A5780G:His1927Arg) in the phospholipase C epsilon gene (PLCϵ) was recently identified as a susceptibility locus for esophageal cancer in Chinese subjects.
|
23390063 |
2013 |
|
Malignant neoplasm of esophagus
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Multiple studies with large clinic-based cohorts revealed that variations of the phospholipase C epsilon (PLCE1) gene were associated with esophageal cancer susceptibility.
|
28147304 |
2017 |
|
Malignant neoplasm of esophagus
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
To investigate the effect and mechanism of phospholipase C epsilon gene 1 (<i>PLCE1</i>) expression on esophageal cancer cell lines.
|
30450849 |
2018 |
|
Prostate carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
MATERIAL AND METHODS We assessed PLCε and PTEN expression in human benign prostate tissues compared to prostate cancer tissues by immunohistochemistry.
|
29330357 |
2018 |
|
Prostate carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that PLCε is a putative oncogene and prognostic marker, potentially representing a novel therapeutic target for PCa.
|
25796442 |
2015 |
|
Prostate carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
It was found that the PLCε expression was excessively upregulated in the majority of CRPC tissues, and PLCε positivity was linked to poor progression‑free survival (PFS) and overall survival (OS) in patients with PCa.
|
30864728 |
2019 |
|
Carcinoma of bladder
|
0.030 |
Biomarker
|
disease |
BEFREE |
The knockdown of PLCε by shRNA could inhibit bladder tumor growth and might be an alternative approach for human bladder cancer therapy.
|
21705050 |
2011 |
|
Carcinoma of bladder
|
0.030 |
Biomarker
|
disease |
BEFREE |
Collectively, the present study demonstrated that PLCε may regulate glycolysis through the STAT3/LDHA pathway to take part in the development of human UBC.
|
30864733 |
2019 |
|
Carcinoma of bladder
|
0.030 |
Biomarker
|
disease |
BEFREE |
Knockdown of phospholipase C-epsilon by short-hairpin RNA-mediated gene silencing induces apoptosis in human bladder cancer cell lines.
|
23484808 |
2013 |
|
Bladder Neoplasm
|
0.020 |
Biomarker
|
disease |
BEFREE |
Knockdown of phospholipase C-epsilon by short-hairpin RNA-mediated gene silencing induces apoptosis in human bladder cancer cell lines.
|
23484808 |
2013 |
|
Bladder Neoplasm
|
0.020 |
Biomarker
|
disease |
BEFREE |
The knockdown of PLCε by shRNA could inhibit bladder tumor growth and might be an alternative approach for human bladder cancer therapy.
|
21705050 |
2011 |
|
Colorectal Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Association between phospholipase C epsilon gene (PLCE1) polymorphism and colorectal cancer risk in a Chinese population.
|
24496148 |
2014 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Phospholipase C epsilon plays a suppressive role in incidence of colorectal cancer.
|
21667163 |
2012 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
Phospholipase C epsilon plays a suppressive role in incidence of colorectal cancer.
|
21667163 |
2012 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Association between phospholipase C epsilon gene (PLCE1) polymorphism and colorectal cancer risk in a Chinese population.
|
24496148 |
2014 |
|
Alzheimer's Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Thus these APP and PRIP mutations are rare in both FAD and nonfamilial AD.
|
1679288 |
1991 |
|
Anorexia
|
0.010 |
Biomarker
|
disease |
BEFREE |
PRIP gene (Prip1 and Prip2) knockout (Prip-KO) mice intraperitoneally (ip) administered with LPS exhibited increased anorexia responses compared with wild-type (WT) controls.
|
31589911 |
2019 |
|
Aortic Valve Insufficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, we demonstrate that the activation of both the Notch and AR signalling pathways is involved in PLCε-mediated oncogenic effects in PCa.
|
25796442 |
2015 |
|
Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings suggest that PLCε promotes RCC cell growth via NF-κB-mediated upregulation of VEGF.
|
24510280 |
2014 |
|
Dermatomyositis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Recently, phospholipase C-like 1 (PLCL1) has been identified as a potential genetic susceptibility locus for dermatomyositis (DM) in patients of European ancestry.
|
26603167 |
2016 |
|
Esophagitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis.
|
23390063 |
2013 |
|
Gerstmann-Straussler-Scheinker Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We also tested for the APP codon 693 mutation associated with hereditary cerebral hemorrhage with amyloidosis-Dutch type, for PRIP gene missense mutations at codons 102, 117, and 200, and for the PRIP insertion mutations which are associated with Creutzfeld-Jakob disease and Gerstmann-Straussler Scheinker syndrome.
|
1679288 |
1991 |
|
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the present study, the expression of PLCε and glioma‑associated homolog (Gli)‑1/Gli‑2 in benign prostatic hyperplasia (BPH), PCa and CRPC tissues and cells was investigated, and the correlations between PLCε and Gli‑1/Gli‑2 in CRPC tissues and cell lines were further explored.
|
30864728 |
2019 |
|
Kidney Failure, Chronic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Using positional cloning, we identified mutations in the phospholipase C epsilon gene (PLCE1) as causing early-onset nephrotic syndrome with end-stage kidney disease.
|
17086182 |
2006 |
|
Osteosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Silencing of phosphoinositide-specific phospholipase C ε remodulates the expression of the phosphoinositide signal transduction pathway in human osteosarcoma cell lines.
|
25075031 |
2014 |