IL17D, interleukin 17D, 53342

N. diseases: 259; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.060 AlteredExpression disease BEFREE Notably, increased expression of IL-23 and IL-27 transcripts in CD suggests a T helper 1-dominated immunologic function in this disease. 15674109 2005
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.060 Biomarker disease BEFREE In this study we compared the effects of plasmids expressing both chains of IL-12, IL-23, or IL-27 as adjuvants for DNA immunization against M. tuberculosis infection. 16369012 2006
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis 		0.010 Biomarker disease BEFREE In this study we compared the effects of plasmids expressing both chains of IL-12, IL-23, or IL-27 as adjuvants for DNA immunization against M. tuberculosis infection. 16369012 2006
CUI: C0025202
Disease: melanoma
melanoma 		0.040 Biomarker disease BEFREE In this study, we further evaluated the antitumor and antiangiogenic activities of IL-27, using poorly immunogenic murine melanoma B16F10 tumors, which were engineered to overexpress single-chain IL-27 (B16F10 + IL-27). 16751375 2006
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.010 AlteredExpression disease BEFREE We have recently demonstrated that IL-27 has potent antitumor activity, which is mainly mediated through CD8(+) T cells, against highly immunogenic murine colon carcinoma. 16751375 2006
CUI: C0004096
Disease: Asthma
Asthma 		0.060 GeneticVariation disease BEFREE Although signaling of IL-27/WSX-1 interactions have been recognized in the down-regulation of airway hyper-reactivity and in lung inflammation during the development of allergic asthma, little is known about the role of single nucleotide polymorphisms (SNPs) of IL-27 and individual susceptibility to asthma. 17318299 2007
CUI: C0032285
Disease: Pneumonia
Pneumonia 		0.040 GeneticVariation disease BEFREE Although signaling of IL-27/WSX-1 interactions have been recognized in the down-regulation of airway hyper-reactivity and in lung inflammation during the development of allergic asthma, little is known about the role of single nucleotide polymorphisms (SNPs) of IL-27 and individual susceptibility to asthma. 17318299 2007
CUI: C3714636
Disease: Pneumonitis
Pneumonitis 		0.040 GeneticVariation disease BEFREE Although signaling of IL-27/WSX-1 interactions have been recognized in the down-regulation of airway hyper-reactivity and in lung inflammation during the development of allergic asthma, little is known about the role of single nucleotide polymorphisms (SNPs) of IL-27 and individual susceptibility to asthma. 17318299 2007
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior 		0.010 GeneticVariation phenotype BEFREE Although signaling of IL-27/WSX-1 interactions have been recognized in the down-regulation of airway hyper-reactivity and in lung inflammation during the development of allergic asthma, little is known about the role of single nucleotide polymorphisms (SNPs) of IL-27 and individual susceptibility to asthma. 17318299 2007
CUI: C0042164
Disease: Uveitis
Uveitis 		0.030 Biomarker disease BEFREE These findings suggest that T(H)1 cells may mitigate uveitis by antagonizing the T(H)17 phenotype through the IFN-gamma-mediated induction of IL-27 in target tissue. 17496900 2007
CUI: C0036416
Disease: Scleritis
Scleritis 		0.010 Biomarker disease BEFREE TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. 17496900 2007
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE More effective application of this cytokine, and of newly identified IL-12 family members (IL-23 and IL-27), should be evaluated as therapeutic agents with considerable potential in cancer patients. 17699845 2007
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker group BEFREE More effective application of this cytokine, and of newly identified IL-12 family members (IL-23 and IL-27), should be evaluated as therapeutic agents with considerable potential in cancer patients. 17699845 2007
CUI: C0003864
Disease: Arthritis
Arthritis 		0.040 Biomarker disease BEFREE We determined the involvement of IL-27 in PGIA by assessing the progression of arthritis in IL-27R-/- mice. 18178832 2008
CUI: C0036690
Disease: Septicemia
Septicemia 		0.060 AlteredExpression disease BEFREE We conclude that the deficient pro-inflammatory response in patients with sepsis is expansive and includes deficient IL-23 and excessive IL-27 gene expression. 18227999 2008
CUI: C0243026
Disease: Sepsis
Sepsis 		0.060 AlteredExpression disease BEFREE We conclude that the deficient pro-inflammatory response in patients with sepsis is expansive and includes deficient IL-23 and excessive IL-27 gene expression. 18227999 2008
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.020 AlteredExpression disease BEFREE As alternative regulators of IFNgamma may be of greater importance in human sepsis, we investigated the hypothesis that the development of severe sepsis is related to variations in IL-18, IL-23 and IL-27 gene expression. 18227999 2008
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE Thus, IL-27 may be an attractive candidate as an antitumor agent applicable to cancer immunotherapy. 18453571 2008
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE IL-27 augmented the expression of IFN regulatory factor (IRF)-1 and IRF-8, which possess tumor suppressor activities, in B16F10 transfectants expressing wild-type WSX-1. 18453571 2008
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker group BEFREE Thus, IL-27 may be an attractive candidate as an antitumor agent applicable to cancer immunotherapy. 18453571 2008
CUI: C0025202
Disease: melanoma
melanoma 		0.040 AlteredExpression disease BEFREE In this study, we demonstrate that IL-27 also possesses a direct antiproliferative activity on melanoma. 18453571 2008
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma 		0.030 AlteredExpression disease BEFREE IL-27-mediated activation of natural killer cells and inflammation produced antitumour effects for human oesophageal carcinoma cells. 18482209 2008
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.050 GeneticVariation disease BEFREE When compared with the control group, subjects with AG genotype of the IL-27 -964A/G had a 2.22-fold decreased risk of COPD (odds ratio [OR] = 0.450, 95% confidence interval [CI]: 0.245-0.826; p = 0.009), and subjects with TG genotype of the IL-27 2905T/G had a 2.85-fold decreased risk of COPD (OR = 0.351, 95% CI: 0.137-0.899; p = 0.024). 18554158 2008
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.040 AlteredExpression disease BEFREE To determine the correlation between HBV infection and IL-27 expression, we investigated the serum IL-27 levels in patients with HBV infection and in healthy individuals. 19081304 2009
CUI: C0524909
Disease: Hepatitis B, Chronic
Hepatitis B, Chronic 		0.020 AlteredExpression disease BEFREE IL-27 was also detected at higher levels in patients with liver cirrhosis or hepatocellular carcinoma than those with acute hepatitis B or chronic hepatitis B (P<0.05). 19081304 2009