Hyperglycemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
PANDER transgenic mice display fasting hyperglycemia and hepatic insulin resistance.
|
24468680 |
2014 |
Hyperglycemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
Hepatic PANDER silencing also attenuated insulin resistance and hyperglycemia in db/db mice.
|
21412813 |
2011 |
Hyperglycemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We found that FAM3B expression was induced by hyperglycemia both in vivo and in vitro.
|
28536423 |
2017 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
Biomarker
|
disease |
BEFREE |
Under obese state, the imbalance among hepatic FAM3A, FAM3B and FAM3C signaling networks plays important roles in the pathogenesis of NAFLD and type 2 diabetes.
|
29221790 |
2018 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
Biomarker
|
disease |
BEFREE |
Association of serum pancreatic derived factor (PANDER) with beta-cell dysfunction in type 2 diabetes mellitus.
|
28161382 |
2017 |
Down Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
In contrast, no comparable cardiac defects were detected in embryos of the more limited mouse trisomy model, Dp(16Cbr1-ORF9)1Rhr (Ts1Rhr), indicating that trisomy of the region syntenic to the Down's syndrome critical region, including the candidate genes DSCAM and DYRK1A, is insufficient to yield DS cardiac abnormalities.
|
20558441 |
2010 |
Down Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results revealed the high levels of complexities of gene actions and interactions associated with the Setd4/Cbr1-Fam3b/Mx2 region as well as their relationship with developmental cognitive deficits in DS.
|
26374847 |
2015 |
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
FAM3B has been suggested to play important roles in the progression of many cancers, such as gastric, oral, colon and prostate cancer.
|
30565387 |
2019 |
Malignant neoplasm of prostate
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Taken together, by activating pro-survival mechanisms FAM3B overexpression contributes to increased resistance to cell death and tumor growth in nude mice, highlighting a putative role for this cytokine in prostate cancer progression.
|
29357840 |
2018 |
Non-alcoholic Fatty Liver Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this brief review, we discussed the latest findings regarding the role of FAM3 gene family members, in particular FAM3B, in the pathogenesis of NAFLD.
|
23855304 |
2013 |
Non-alcoholic Fatty Liver Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Under obese state, the imbalance among hepatic FAM3A, FAM3B and FAM3C signaling networks plays important roles in the pathogenesis of NAFLD and type 2 diabetes.
|
29221790 |
2018 |
Prostate carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
FAM3B has been suggested to play important roles in the progression of many cancers, such as gastric, oral, colon and prostate cancer.
|
30565387 |
2019 |
Prostate carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Taken together, by activating pro-survival mechanisms FAM3B overexpression contributes to increased resistance to cell death and tumor growth in nude mice, highlighting a putative role for this cytokine in prostate cancer progression.
|
29357840 |
2018 |
Varicella zoster
|
0.020 |
Biomarker
|
disease |
BEFREE |
Functions of the ORF9-to-ORF12 gene cluster in varicella-zoster virus replication and in the pathogenesis of skin infection.
|
18400847 |
2008 |
Varicella zoster
|
0.020 |
Biomarker
|
disease |
BEFREE |
We previously demonstrated that the ORF9 gene is essential, whereas ORF11 is dispensable in vitro but its deletion severely impairs VZV infection of skin xenografts in the SCID mouse model in vivo.
|
23427162 |
2013 |
DOWN SYNDROME CRITICAL REGION
|
0.020 |
Biomarker
|
disease |
BEFREE |
DSCR is conserved between the Cbr1 and Fam3b genes on Mmu16.
|
24041763 |
2014 |
DOWN SYNDROME CRITICAL REGION
|
0.020 |
Biomarker
|
disease |
BEFREE |
In contrast, no comparable cardiac defects were detected in embryos of the more limited mouse trisomy model, Dp(16Cbr1-ORF9)1Rhr (Ts1Rhr), indicating that trisomy of the region syntenic to the Down's syndrome critical region, including the candidate genes DSCAM and DYRK1A, is insufficient to yield DS cardiac abnormalities.
|
20558441 |
2010 |
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that FAM3B was expressed in mouse colon, intestine, liver and lung tissues and multiple types of cell lines, including murine pancreatic β-cell (Min6), microglia (N9) and muscle cell (C2C12); human colon cancer cells (HCT8, HCT116, HT29), hepatocyte (HL-7702), hepatocellular carcinoma cell (SMMC-7721) and lung carcinoma cell (A549).
|
23246487 |
2013 |
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Here we found that its non-secretory form FAM3B-258 was highly expressed in most colon cancer cell lines and colorectal adenocarcinoma tissues but not hepatocellular carcinoma, lung carcinoma and pancreatic adenocarcinoma cell lines.
|
23059759 |
2013 |
Complete Trisomy 21 Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
In contrast, no comparable cardiac defects were detected in embryos of the more limited mouse trisomy model, Dp(16Cbr1-ORF9)1Rhr (Ts1Rhr), indicating that trisomy of the region syntenic to the Down's syndrome critical region, including the candidate genes DSCAM and DYRK1A, is insufficient to yield DS cardiac abnormalities.
|
20558441 |
2010 |
Complete Trisomy 21 Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results revealed the high levels of complexities of gene actions and interactions associated with the Setd4/Cbr1-Fam3b/Mx2 region as well as their relationship with developmental cognitive deficits in DS.
|
26374847 |
2015 |
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that FAM3B-258 promotes colon cancer cell invasion and metastasis through upregulation of Slug.
|
23059759 |
2013 |
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anthropometric parameters, routine biochemical markers and serum levels of PANDER were measured in 63 diabetic subjects including; recently diagnosed type 2 diabetic patients with duration of diabetes ≤6months and long-standing type 2 diabetic patients with duration of diabetes ≥5years then compared to 16 healthy control volunteers.
|
28161382 |
2017 |
Fatty Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
PANDER may represent a potential therapeutic target for the treatment of fatty liver and insulin resistance.
|
21412813 |
2011 |
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we over-expressed CLN3P in SH-SY5Y neuroblastoma cells and monitored the effects on PANDER-induced apoptosis.
|
16515873 |
2006 |