West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Incidence of Hypertension Among Children Treated With Adrenocorticotropic Hormone (ACTH) or Prednisolone for Infantile Spasms.
|
31769329 |
2020 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Comparison of efficacies of zonisamide versus adrenocorticotropic hormone was as following: the cessation of epileptic spasms (27% vs. 40%, p = 0.70), resolution of hypsarrhythmia at 14 days (20% vs. 33%, p = 0.68) and resolution of hypsarrhythmia at 6 weeks (36% vs. 71%, p = 0.14).
|
30293931 |
2019 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, AQB-565 may represent a novel treatment of infantile spasms similarly effective as ACTH but with potentially limited side effects.
|
30875634 |
2019 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
West Syndrome pharmacological treatment usually consists in antiepileptic drugs and/or ACTH.
|
31724502 |
2019 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Efficacy and tolerability of the ketogenic diet versus high-dose adrenocorticotropic hormone for infantile spasms: A single-center parallel-cohort randomized controlled trial.
|
30801699 |
2019 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Very-High-Dose Prednisolone Before ACTH for Treatment of Infantile Spasms: Evaluation of a Standardized Protocol.
|
31331669 |
2019 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Effectiveness of corticosteroids versus adrenocorticotropic hormone for infantile spasms: a systematic review and meta-analysis.
|
31657133 |
2019 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
The OR point estimate showed the superiority of adrenocorticotropic hormone over all comparators in infantile spasms.
|
29270989 |
2018 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Serial Analysis of Multiple Serum Cytokine Responses to Adrenocorticotropic Hormone Therapy in Patients With West Syndrome.
|
29724126 |
2018 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Since ACTH, the first line treatment for IS, has inconsistent efficacy and potential harsh side effects, PMX53, a potent complement C5ar1 antagonist, was suggested as a therapeutic alternative given its effects in other epilepsy models.
|
29636502 |
2018 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adrenocorticotropic hormone (ACTH), vigabatrin (VGB) and corticosteroids are the first-line treatments for WS.
|
29086890 |
2018 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Topiramate, levetiracetam, zonisamide, and sodium valproate with benzodiazepine (clonazepam or nitrazepam) were found to be potential drugs for treating West syndrome besides adrenocorticotropic hormone, steroids, and vigabatrin.
|
28288483 |
2017 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
The current treatment options include hormonal treatment (adrenocorticotropic hormone and high-dose steroids) and the GABA aminotransferase inhibitor vigabatrin, while ketogenic diet can be given as add-on treatment in refractory IS.
|
28427564 |
2017 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adrenocorticotropic hormone (ACTH) is the only medicine for treating infantile spasms, however, it is catabolized rapidly.
|
28127707 |
2017 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Infants with hypsarrhythmia were more likely to receive standard treatment (adrenocorticotropic hormone, prednisolone, or vigabatrin [odds ratio (OR) 2.6, 95% confidence interval (CI) 1.4-4.7] and preexisting epilepsy reduced the likelihood of standard treatment (OR 3.2, 95% CI 1.9-5.4).
|
29105055 |
2017 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
We encountered a 2-month-old boy with infantile spasms that had been treated with ACTH and had developed complicating Fournier's gangrene.
|
28007393 |
2017 |
West Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Infants with untreated West syndrome were randomized to receive 14 days of prednisolone (40 to 60 mg/day) or intramuscular long-acting ACTH (40 to 60 IU every other day).
|
28927673 |
2017 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Her infantile spasms and hypsarrhythmia disappeared promptly by adrenocorticotropic hormone therapy (CORTROSYN®Z, 0.0125mg/kg/day daily for 2weeks intramuscularly), though the administration of pyridoxal phosphate and valproic acid had poor efficacy.
|
28551038 |
2017 |
West Syndrome
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We conducted a retrospective, chart review of IS cases that were treated with biologic short-acting ACTH and followed up for at least 6 months at a single center in China between June 2010 and June 2016.
|
28421469 |
2017 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adrenocorticotropic hormone (ACTH) therapy is the first-line therapy for infantile spasms, and is effective for many other intractable epilepsies.
|
25149137 |
2015 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, we also found that a 4-SNP haplotype (CAGC) which contains the aforementioned 2 SNPs, was associated with increased responsiveness to ACTH therapy in IS (p = 0.018, OR = 4.8) under recessive model.
|
25268096 |
2014 |
West Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the present study, the contribution of 5-HTT polymorphisms to the risk of infantile spasm (IS) and the responsiveness to adrenocorticotropic hormone (ACTH) were investigated.
|
23775678 |
2013 |
West Syndrome
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Vigabatrin and ACTH showed no significant difference in the initial treatment of infantile spasms.
|
20078871 |
2010 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, it may be a candidate gene to be tested for responsiveness to ACTH in infantile spasms.
|
20722663 |
2010 |
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adrenocorticotropin hormone (ACTH) has been the standard treatment to infantile spasms (IS).
|
20042918 |
2010 |